Oakland Athletics vs San Francisco Giants Prediction 5/16/25 MLB Picks

The Athletics are visiting the San Francisco Giants on Friday, May 16th at the Oracle Park in the opening game of this series. We will look at this from a betting perspective and determine the best bets for this game. Here’s an Athletics vs San Francisco Giants Prediction. We will examine:

The San Francisco Giants’ recent form and player performance

The Athletics’ recent form and player performance

Recent betting trends and streaks involving the San Francisco Giants

Recent betting trends and streaks involving the Athletics

Recent betting trends in games played between the Athletics vs San Francisco Giants

A summary that ties it all together and produces a favorable betting outcome for the Athletics vs San Francisco Giants game

San Francisco Giants Preview

The San Francisco Giants have a 25-19 record this season and are sitting in third place in the NL West. They have a 13-7 home record and are 26-18 in over/under. They are coming off a 7-8 home defeat by the Arizona Diamondbacks, and are 1-5 in their last 6 games. Over is 3-1 in their last 4 games, and they are playing the Nationals and the Royals next.

The Giants have a .237 batting average this season, a .312 OBP, and a .386 Slugging percentage. San Francisco’s pitching staff has a 3.56 ERA and 1.25 WHIP.  Jung Hoo Lee leads the Giants with 48 hits, while Wilmer Flores leads the team in RBI with 33, and Matt Chapman adds a team-high 8 home runs. Heliot Ramos is the team’s best hitter, with a .288 batting average

Logan Webb (R) will take the mound for the Giants, and he has a 4-3 record, 2.60 ERA, and 1.16 WHIP. He has been lights out at home, with just one earned run in 20.1 innings pitched across three home starts. His only start against the A’s last season was a shutout performance, with zero earned runs across 9 innings pitched as the Giants won 1-0.  

Athletics Preview

The Athletics have a 22-22 record this season and are sitting in 4th place in the AL West. The Athletics have a 14-9 road record and are 23-17 in over/under. They are coming off a 2-19 road defeat by the Dodgers, and are 2-6 in their last 8 games. Over is 6-1 in their last 7 games, and they are playing the Phillies and the Angels next.

The Athletics have a .258 batting average this season, a .317 OBP, and a .428 Slugging percentage. Athletics’ pitching staff has a 5.18 ERA and 1.50 WHIP. Jacob Wilson leads the Athletics with 58 hits and a team-high .347 batting average. Tyler Soderstrom leads the team with 29 RBI.

JP Sears (L) will take the mound for the Athletics, and he has a 4-2 record, 2.80 ERA, and 1.00 WHIP. He has been better on the road, with a 2.32 ERA, and he has not given up more than 2 runs in each of his last five starts. He was excellent against the Giants last season, giving up only one run in 14.2 innings pitched across two starts.  

Why the San Francisco Giants will win

• The Athletics have lost eight of their last nine road games against NL West opponents that held a winning record.
• The Giants have won eight of their last nine games following a home loss.
• The Giants have covered the run line in each of their last six games at Oracle Park.
• The Athletics have failed to cover the run line in each of their last four road games after playing the previous day.
• The Athletics have lost the first inning in three of their last four games against National League opponents that held a winning record.
• The Giants have led after 5 innings in each of their last three games as home favorites.
• The Giants have led after 3 innings in each of their last three games as home favorites.

Why the Athletics will win

• The Athletics have won four of their last five games as underdogs against the Giants following a road loss.
• The Giants have lost seven of their last eight Friday night games as home favorites against American League opponents.
• The Giants have failed to cover the run line in each of their last eight games as favorites against American League opponents.
• The underdogs have covered the run line in each of the Giants’ last eight games.
• The Giants have trailed after 3 innings in seven of their last eight games as favorites against American League opponents.
• The Giants have lost the first inning in three of their last four home games against AL West opponents.
• The Giants have trailed after 5 innings in four of their last five night games against American League opponents.

Total Runs Facts

• Each of the Athletics’ last nine games as underdogs have gone OVER the total runs line.
• Each of the Giants’ last seven games as favorites against American League opponents have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Athletics’ last 10 Friday night games.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the last four games between the Athletics and Giants.

Matchup/League Facts

• The Giants rank 4th in the league for home runs allowed this season (37).
• The Giants rank 8th in the league for runs scored this season (209).
• The Athletics rank 30th in the league for walks allowed this season (179).
• The Athletics rank 29th in the league for hits allowed this season (410).

Athletics vs San Francisco Giants Prediction

The Athletics are 4-2 in their last 6 overall meetings against the Giants, but the Giants are 3-1 in their last 4 meetings in San Francisco. All four of their meetings last season went under the total, with 4 average total runs. 

In this Athletics vs San Francisco Giants Prediction, the Giants are coming as home favorites. Both pitchers have been outstanding to start the season, with a combined 5.40 ERA. The Giants have the best bullpen in the MLB, and are much weaker against lefties, with just 3.6 runs per game. Their four meetings last season had only 4 average total runs, and I like another under here. Take the under 7 runs.