Cleveland Guardians vs Cincinnati Reds Prediction 5/16/25 MLB Picks

The Cleveland Guardians and the Cincinnati Reds meet Friday in MLB action from Great American Ballpark. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Cleveland Guardians vs. Cincinnati Reds prediction.

Starting Pitching Matchup

Tanner Bibee will get the start for the Guardians here, and Bibee is 3-3 with a 3.80 ERA and 31 strikeouts this season. In his career, Bibee is 1-1 with a 3.65 ERA and 18 strikeouts against the Reds. The Cincinnati Reds will send out Brady Singer for the start here, and Singer is 4-2 with a 4.97 ERA and 39 strikeouts this season. In his last five starts against the Guardians, Singer is 0-2 with a 4.78 ERA and 15 strikeouts.

Cleveland Guardians Recap

The Cleveland Guardians come into this game looking to bounce back after their 9-5 loss at the hands of the Milwaukee Brewers last time out, to sit at 25-18 on the year. After this series, the Guardians will head on the road for a series against the Minnesota Twins.

Guardians Looking To Rebound After Failing To Complete Sweep

Steven Kwan leads the Guardians with 55 hits as part of a .325 batting average and 4 home runs, 9 doubles, and 17 RBIs. Kyle Manzardo has 29 hits with 3 doubles, 2 triples, 10 home runs, and a team-high 25 RBIs this year. Gabriel Arias has 8 doubles but also 40 strikeouts, and Manzardo has a team-high 41 strikeouts so far this season. Arias has also added 4 home runs and 19 RBIs, and Jose Ramirez has chipped in 8 home runs and 22 RBIs.

Why the Cleveland Guardians will win

• The Reds have lost each of their last 11 home games against AL Central opponents following a win.
• The Guardians have won each of their last six night games against National League opponents that held a losing record.
• The Reds have failed to cover the run line in each of their last 13 home games against AL Central opponents following a win.
• The Guardians have covered the run line each of their last six night games against National League opponents that held a losing record.

Cleveland Guardians Player Prop Facts

• Jose Ramirez has hit a home run in three of the Guardians’ last four games as favorites against NL Central opponents.
• Jose Ramirez has recorded an RBI in each of the Guardians’ last four games as road favorites against the Reds.
• Steven Kwan has recorded a Double in three of the Guardians’ last four night games against opponents that held a losing record.
• Steven Kwan has recorded at least one hit in each of his last 14 appearances with the Guardians as road favorites.
• Lane Thomas has scored at least one run in each of his last nine appearances with his team as a road favorite against NL opponents.
• Steven Kwan has recorded at least one Single in each of his last 14 appearances with the Guardians as road favorites.
• Steven Kwan ranks T4th in the league in Hits (55) this season.

Cincinnati Reds Recap

The Cincinnati Reds come into this game looking to build on their 7-1 win over the White Sox last time out to improve to 21-24 on the year. After this series, the Reds will head on the road for a series against the Pittsburgh Pirates.

Reds Snap Three-Game Losing Skid

Elly De La Cruz has a team-high 45 hits with 8 home runs, 31 RBIs, and 14 stolen bases, while TJ Friedl has 43 hits with 6 doubles and 17 RBIs with 8 stolen bases. Gavin Lux has added 41 hits with a team-high 10 doubles and 19 RBIs, while Spencer Steer has 4 home runs and 12 RBIs, and Matt McLain has added 6 homers, 16 RBIs, and 10 stolen bases as well on the year. Jose Trevino’s also chipped in 10 doubles this season.

Why the Cincinnati Reds will win

• The Reds have won five of their last seven games as home underdogs against American League opponents.
• The Guardians have lost five of their last seven games as road favorites against NL Central opponents.
• The Reds have covered the run line each of their last five night games against teams that held a winning record.
• The Guardians have failed to cover the run line in each of their last five games as road favorites following a home loss.

Cincinnati Reds Player Prop Facts

• Brady Singer has recorded five or more strikeouts in each of his last nine Friday appearances against teams that held a winning record.
• Jeimer Candelario has hit at least one home run in two of his last three home appearances against the Guardians.
• TJ Friedl has recorded at least one Single in each of the Reds’ last six games against AL Central opponents that held a winning record.
• Jeimer Candelario has recorded at least one RBI in each of his last four appearances against the Guardians.
• Jose Trevino has recorded a Double in each of his last five appearances with the Reds as underdogs against AL opponents.
• TJ Friedl has recorded at least one hit in each of his last 12 appearances with the Reds as underdogs against AL Central opponents.
• Elly De La Cruz has scored at least one run in seven of the Reds’ last eight home games.
• Elly De La Cruz ranks 4th in the league in Steals (14) this season.

Total Runs Facts

• Eight of the Guardians’ last nine games as road favorites have gone OVER the total runs line.
• Eight of the last nine games between the Guardians and Reds have gone UNDER the total runs line.

Cleveland Guardians vs. Cincinnati Reds Prediction

I’m on the Guardians here. I was initially considering the over because I’m not the biggest Bibee fan, and he did struggle in his lone career start at Great American Ballpark. However, the form Singer is in is far from inspiring right now, and I just think that the Guardians can get to him and do enough to get the win in this one. Give me the Cleveland Guardians on the road to draw first blood here.