San Francisco Giants vs Chicago Cubs Prediction 5/6/25 MLB Picks

Giants Have Three-Game Win Streak Snapped

Jung Hoo Lee leads the Giants with 40 hits, including a team-high 11 doubles along with a pair of triples, 3 home runs, and 20 RBIs with 3 stolen bases, while Heliot Ramos has 32 hits with 7 doubles, 5 home runs, and 12 RBIs. Wilmer Flores also has a team-high 7 home runs and 31 RBIs, while Mike Yastrzemski has 5 home runs with 17 RBIs and 7 doubles, and Tyler Fitzgerald has a team-high 5 stolen bases as well on the year.

Why the San Francisco Giants will win

• The Giants have won eight of their last 10 games as underdogs following a road loss.
• The Cubs have lost 13 of their last 20 games as home favorites against National League opponents following a home win.
• The Cubs have failed to cover the run line in each of their last four night games against NL West opponents following a win.
• The Giants have covered the run line in five of their last six games against NL Central opponents following a loss.

San Francisco Giants Player Prop Facts

• LaMonte Wade Jr has hit a home run in each of his three previous appearances with the Giants as underdogs against the Cubs.
• Wilmer Flores has recorded at least one RBI in four of his last five appearances in night games against NL Central teams that held a winning record.
• Heliot Ramos has scored at least one run in nine of the Giants' last 10 road games against NL opponents.
• Justin Verlander has recorded five or more strikeouts in four of his last five road appearances against NL Central opponents.
• Jung Hoo Lee has recorded at least one Single in each of his last 11 appearances with the Giants as underdogs against NL opponents.
• Jung Hoo Lee has recorded at least one hit in each of his last 11 appearances with the Giants as underdogs against NL opponents.
• Casey Schmitt has recorded a Double in three of his last four appearances against NL Central opponents that held a winning record.

Chicago Cubs Recap

The Chicago Cubs come into this game looking to build on their win over the Giants from Monday’s opener to improve to 22-14 on the year. After this series, the Cubs will head on the road for a series against the New York Mets.

Cubs Win 4 Of Their Last 5

Ian Happ has a team-high 43 hits with 9 doubles, 3 home runs, and 19 RBIs. Kyle Tucker has 40 hits, including 8 doubles, 9 home runs, and 30 RBIs, while Seiya Suzuki also has 35 hits with 6 doubles and 9 home runs and 31 RBIs of his own. Miguel Amaya added 6 doubles and 14 RBIs, and Pete Crow-Armstrong has also contributed 10 doubles this season. Dansby Swanson has added 7 home runs and 20 RBIs, while he also has the unfortunate distinction of leading the Cubs with 44 strikeouts so far this season. Crow-Armstrong also has a team-high 12 stolen bases, while Nico Hoerner has 7 stolen bases this season. Tucker’s also added 9 stolen bases while Michael Busch has also chipped in 6 home runs and 22 RBIs this season.

Why the Chicago Cubs will win

• The Giants have lost each of their last eight games at Wrigley Field against NL Central opponents that held a winning record.
• The home team has won eight of the Giants' last nine games.
• The Giants have failed to cover the run line each of their last seven games against teams that held a winning record.
• The home team has covered the run line in each of the Giants' last four games.

Chicago Cubs Player Prop Facts

• Ian Happ has hit a home run in three of the Cubs' last four home games against the Giants.
• Ian Happ has recorded at least one RBI in each of the Cubs' last six games as favorites against the Giants.
• Dansby Swanson has scored at least one run in eight of the Cubs' last nine night games.
• Nico Hoerner has recorded at least one Single in each of the Cubs' last nine Tuesday games against opponents that held a winning record.
• Justin Turner has recorded at least one hit in each of his last 11 appearances with his team as a favorite against the Giants.
• Pete Crow-Armstrong ranks 4th in the league in Steals (12) this season.

Total Runs Facts

• Each of the Giants' last 11 games as underdogs have gone OVER the total runs line.
• Each of the Cubs' last four games as favorites against the Giants have gone OVER the total runs line.

San Francisco Giants vs. Chicago Cubs Prediction

I’m on the Cubs here. The Cubs have been solid so far this season and keep finding ways to produce at home, as has Ben Brown, who has great numbers at Wrigley Field so far this season. On the other side, Justin Verlander has been pitching better, but still doesn’t have a win to show for it, and right now I trust this Cubs lineup against righties more than I do the Giants, so give me the Cubs to get it done again here.