Baltimore Orioles vs Minnesota Twins Prediction 5/6/25 MLB Picks

Minnesota Twins Betting Preview

The Minnesota Twins are 15-20 on the year and play the Giants, Orioles, and Brewers next. The Minnesota Twins are batting .236 on the season, have a .307 OBP, and a .367 slugging percentage. The Minnesota Twins pitching staff has a 3.60 ERA and a 1.22 WHIP. Byron Buxton leads the Minnesota Twins with 33 hits and 18 RBI, while Ty France and Trevor Larnach have combined for 60 hits and 35 RBI.

Pablo Lopez gets the ball for the Minnesota Twins, and he is 2-2 with a 2.25 ERA and 26 strikeouts this season. Lopez is 2-1 with a 1.59 ERA and 28 strikeouts in his career against the Baltimore Orioles.

Why the Minnesota Twins will win

• The Orioles have lost each of their last eight games at Target Field against teams that held a losing record.
• The Twins have won seven of their last eight home games.
• The Twins have covered the run line in each of their last nine Tuesday night games against American League opponents.
• The Orioles have failed to cover the run line in six of their last seven games against teams that held a losing record.
• The Twins have led after 3 innings in six of their last seven home games against American League opponents.
• The Orioles have lost the first inning in three of their last four games against American League opponents that held a losing record.
• The Twins have led after 5 innings in each of their last three home games against American League opponents.

Why the Baltimore Orioles will win

• The Orioles have won each of their last 10 games against the Twins.
• The Twins have lost four of their last five games as favorites against the Orioles following a win.
• The Orioles have covered the run line in each of their last 10 games at Target Field.
• The Twins have failed to cover the run line in each of their last six games as favorites against AL East opponents following a win.
• The Twins have trailed after 3 innings in four of their last five games as home favorites against AL East opponents.
• The Twins have trailed after 5 innings in seven of their last eight games as favorites against AL East opponents.

Minnesota Twins Player Prop Facts

• Ty France has recorded a Double in three of the Twins' last four games as favorites.
• Ty France has recorded an RBI in each of his last six Tuesday appearances with his team as a favorite.
• Pablo Lopez has recorded a win in five of his last six appearances at Target Field.
• Pablo Lopez has recorded six or more strikeouts in each of his four previous appearances against the Orioles.
• Trevor Larnach has hit a home run in each of the Twins' last two night games against opponents that held a losing record.
• Christian Vazquez has recorded a Single in each of his last four appearances.
• Trevor Larnach has scored at least one run in seven of his last eight appearances after not playing the previous day.
• Trevor Larnach has recorded at least one hit in each of his last eight appearances after not playing the previous day.

Baltimore Orioles Player Prop Facts

• Ryan O'Hearn has hit a home run in three of his last four appearances with the Orioles as road underdogs against AL Central opponents.
• Cedric Mullins has scored at least one run in each of his last four appearances with the Orioles as underdogs against AL Central opponents.
• Adley Rutschman has recorded at least one Single in 14 of the Orioles' last 15 night games against AL Central opponents that held a losing record.
• Ryan Mountcastle has recorded at least one hit in each of his last 11 appearances against the Twins.
• Jordan Westburg has recorded at least one RBI in four of his last five appearances against the Twins.

Baltimore Orioles vs Minnesota Twins Prediction

The Orioles continue to lose, continue to underachieve, and it’s hard to get behind Povich, who has allowed 32 hits and 14 earned runs in his last 25.1 innings. Povich has been one of the worst starting pitchers in baseball up to this point, and that includes allowing a .306 batting average. The Twins are coming off a couple of nice wins over the Red Sox, and now they throw out an all-star pitcher in Lopez, who has allowed five earned runs in his last 23 innings. Lopez is rolling through 28 innings, and he’s holding current Orioles hitters to a .190 batting average and 19 strikeouts in 58 at-bats. Give me the Twins, and I’ll take the RL to shave down the price.