Pittsburgh Pirates vs St. Louis Cardinals Prediction 5/6/25 MLB Picks

-Recent Betting trends and streaks involving Pittsburgh

-Recent Betting trends and streaks involving St. Louis

-Recent betting trends in games played between Pittsburgh and St. Louis

-A summary that ties it all together produces a favorable betting outcome for Today’s Game between the Pirates and Cardinals. 

Pirates Continue to be Bad

The Pirates continue to be bad, and again, the offense let them down in a big way on Monday. The last run they scored came in the 4th inning, and the rest of the game, they couldn’t string together hits, something that has become a far too common occurrence. Bryan Reynolds was a bright spot for the offense, hitting a home run and driving in two RBIs. 

The Pirates are averaging 3.26 runs while their pitching is giving up 4.63 runs per game. The offense is ranked 28th, while the pitching is ranked 22nd. Oneil Cruz has hit eight home runs and driven in 18 RBIs. Getting the start for the Pirates will be Paul Skenes, who sits with a 3-3 record and an ERA of 2.74. Against the Chicago Cubs in his last start, he went five innings, giving up five hits and three runs. He gave up three solo home runs, and he can’t keep giving up the longball. 

Why the Pirates Will Beat the Cardinals 

• The Cardinals have lost nine of their last 10 games as underdogs after playing the previous day.
• The Pirates have won nine of their last 10 games as favorites following a road loss.
• The Cardinals have failed to cover the run line in six of their last seven games after playing the previous day.
• The favorites have covered the run line in three of the Pirates' last four games.

Cardinals Complete the Comeback

The Cardinals had to fight on Monday, but they were able to make the comeback and ended up with the 6-3 victory. The Cardinals scored four runs in the sixth inning, and that was the difference in the victory. Jose Barreo had a huge game, hitting a home run and driving in three RBIs. Miles Mikolas was on the mound, and he went five innings, giving up four hits and three runs. 

The Cardinals are averaging 4.6 runs while their pitching is giving up 4.66 runs per game. The offense is ranked 13th, while the pitching is ranked 23rd. Lars Nootbaar has hit five home runs and driven in 18 RBIs. Getting the start for the Cardinals in this game is going to be Matthew Liberatore, who sits with a 2-3 record and an ERA of 3.44. Against the Reds in his last start, he went three innings, giving up two hits and two runs. 

Why the Cardinals Will Beat the Pirates

• The Pirates have lost each of their last four games as favorites after playing the previous day.
• The Cardinals have won four of their last five games as underdogs against National League opponents.
• The Pirates have failed to cover the run line each of their last six games at Busch Stadium against National League opponents that held a losing record.
• The Cardinals have covered the run line in 16 of their last 18 games as underdogs against the Pirates.

Pittsburgh Pirates vs St Louis Cardinals Prediction

Paul Skenes struggled in the last game because of the long ball, but outside of that, he pitched pretty well. The good news for Skenes is now he gets to face off against the Cardinals, an offense not as good as the Cubs, and that will be the difference here. Liberatore has been strong, sitting with an ERA of 3.44. He’s going to have a strong start, and the Pirates' offense is going to have another awful game. They are averaging only 3.26 runs per game, and they will have some major issues here. Both offenses are going to struggle, and this game will end up staying under the total. Back the under.