Washington Nationals vs Cincinnati Reds Prediction 5/4/25 MLB Picks

Cincinnati Reds (18-16) vs Washington Nationals (15-19)

Game Info: Sunday, May 4, 2025 at 4:10 pm (Great American Ball Park)

M. Gore (L) vs N. Martinez (R)

Betting Odds: Cincinnati Reds -122 / Washington Nationals +102 --- Over/Under: 8.5 Click Here for the Latest Odds

Where to Watch: MLB.TV

In this article, we will formulate a Nationals vs Reds prediction for this MLB game on Sunday, May 4, at Great American Ball Park in Cincinnati, Ohio. Let’s take a look at the prediction for this MLB matchup.

Washington Nationals Betting Preview

The Washington Nationals (15-19, 6-12 Away) split the series with the Mets and lost the one to the Phillies, and then opened this series in Cincinnati with a 6-1 defeat, but responded with an 11-6 victory. Ahmed Rosario led the offense with four RBI, while Nathaniel Lowe and Riley Adams contributed two RBI apiece. Trevor Williams got the win after allowing four runs on nine hits with four strikeouts and two walks in 5.1 innings.

This year, the Nationals average 4.12 runs per game (17th in the MLB) on a .235/.303/.380 triple-slash. When it comes to pitching, the Nationals’ staff has a 5.21 ERA (27th) and 1.43 WHIP (24th). Nathaniel Lowe leads the Nationals with a .252 batting average, six home runs, and 27 RBI this season.

MacKenzie Gore will take the mound for the Nationals on Sunday. The 26-year-old left-hander has a 2-3 record in seven starts this year with a 3.51 ERA and 1.10 WHIP in 41.0 innings.

Cincinnati Reds Betting Preview

The Cincinnati Reds (18-16, 9-9 Home) went through their best stretch of the season, during which they swept the Rockies and recorded five consecutive wins. The Reds then split the series with the Cardinals and won Game 1 against Washington 6-1 before losing Game 2, 11-6. Spencer Steer led the team with two RBI, while Nick Lodolo took the loss after allowing seven runs (six earned) on ten hits with four strikeouts and two walks in 5.1 innings.

This season, the Reds average 5.12 runs per game (5th in the MLB) on a .248/.328/.393 slash line. Regarding pitching, the Reds’ staff has a 3.45 ERA (6th) and 1.09 WHIP (1st). Elly De La Cruz leads the Reds with a .275 batting average, five home runs, and 25 RBI this season.

The projected starting pitcher for the Reds is Nick Martinez, who is 1-3 in six starts this season, with a 4.68 ERA and 1.35 WHIP in 32.2 innings.

Total Runs Facts

  • Each of the Reds' last four day games as favorites have gone UNDER the total runs line.
  • Six of the Nationals' last seven games as underdogs against the Reds have gone OVER the total runs line.
  • The 'Inning 1 OVER 0.5 runs' market has hit in each of the Reds' last six games as home favorites.
  • The 'Inning 1 OVER 0.5 runs' market has hit in six of the Nationals' last seven games as road underdogs against NL Central opponents.

Matchup/League Facts

  • The Reds rank 4th in the league for RBIs this season (168).
  • The Reds rank 4th in the league for hits allowed this season (233).
  • The Nationals rank 27th in the league for ERA this season (5.21).
  • The Nationals rank 27th in the league for hits allowed this season (302).

Nationals vs Reds Prediction

The Nationals won seven of the previous ten H2H encounters, including four of the last five. MacKenzie Gore and Nick Martinez are solid pitchers, but they allowed multiple runs in all but one start this season. Gore allowed a .429 BA in 14 at-bats against the Reds, while Martinez allowed a .318 BA in 22 at-bats against the Nats. I am backing both offenses to score 3+ runs in the opening five innings. Six of the previous nine H2H duels went Over, and I am going with another Over in this one. 

The pick in this article is the opinion of the writer, not a PickDawgz site consensus.

18+ Has gambling become a problem for you? Call the National Problem Gambling Hotline.
1-800-522-4700 | ncpgambling.org

Credit Guaranteed Packages

Packages with Credit Guarantees automatically give you a credit if the package does not turn a profit—the sum of betting all individual picks. THESE ARE NOT PARLAYS UNLESS OTHERWISE CLEARLY STATED. If a credit guaranteed package does not profit, a credit for its full purchase price is automatically issued after picks are graded and verified.

For example, if you purchase a $39.95 package that doesn’t profit, you’ll get a $39.95 credit towards any future purchase(s) on our site. Credits are usually issued within hours of a game’s conclusion, so please allow a few hours for final verification.

To use your credits, log in to your account and add another package or pass to your cart. Credits will automatically reduce what you owe. Any remaining balance will be settled through our payment system, with any leftover credits available future purchases. Credits do not expire.

Dismiss