Cleveland Guardians vs Toronto Blue Jays Prediction 5/4/25 MLB Picks

Guardians Win 4 Of Their Last 5

Steven Kwan leads the Guardians with 41 hits as part of a .323 batting average and 4 home runs, 6 doubles, and 15 RBIs. Kyle Manzardo has 21 hits with 3 doubles, a triple, 8 home runs, and a team-high 20 RBIs as well this year. Gabriel Arias has a team-high 6 doubles but also has a team-high 31 strikeouts, and Manzardo has 29 strikeouts so far this season. Arias has also added 4 home runs and 11 RBIs, and Jose Ramirez has chipped in 5 home runs and 15 RBIs.

Why the Cleveland Guardians will win

• The Guardians have won three of their last four games as underdogs.
• The Blue Jays have lost each of their last four day games against AL Central opponents that held a winning record.
• The Guardians have covered the run line in each of their last seven day games following a road win.
• The Blue Jays have failed to cover the run line in 10 of their last 11 day games following a home loss.

Cleveland Guardians Player Prop Facts

• Steven Kwan has recorded at least one hit in each of the Guardians' last nine games against AL East opponents.
• Carlos Santana has scored at least one run in each of his last four appearances at Rogers Centre against AL East opponents that held a losing record.
• Jose Ramirez has recorded at least one Single in each of his last six appearances in day games.
• Carlos Santana has hit a home run in each of his last four appearances at Rogers Centre against opponents that held a losing record.
• Carlos Santana has recorded at least one RBI in each of his last four appearances at Rogers Centre against opponents that held a losing record.

Toronto Blue Jays Recap

The Toronto Blue Jays will try to rebound from their loss at the hands of the Guardians in Saturday’s clash to drop to 16-17 on the year. After this series, the Blue Jays will head on the road for a series against the Los Angeles Angels.

Blue Jays Have Three-Game Win Streak Snapped

George Springer has 27 hits and Bo Bichette has 39 hits, with Springer adding 3 home runs, a triple, 7 doubles, and 13 RBIs while Bichette has 10 doubles and 13 RBIs. Andres Gimenez has added 20 hits with 4 doubles and 3 home runs and 8 RBIs this season, along with 8 stolen bases, while Anthony Santander has a team-high 31 strikeouts so far this season. Vladimir Guerrero Jr. also has 4 homers, 6 doubles, and 17 RBIs, while Springer also has a .314 batting average up to this point in the year.

Why the Toronto Blue Jays will win

• The Blue Jays have won each of their last 10 home games against the Guardians following a home loss.
• The Guardians have lost each of their last seven day games against AL East opponents following a road win.
• The Guardians have failed to cover the run line in each of their last six road games against AL East opponents following a win.
• The Blue Jays have covered the run line in nine of their last 10 home games against the Guardians following a home loss.

Toronto Blue Jays Player Prop Facts

• Bo Bichette has hit a home run in two of his last three appearances in day games against AL Central teams that held a winning record.
• George Springer has recorded a Double in each of the Blue Jays' last four day games against AL opponents that held a winning record.
• Bo Bichette has recorded an RBI in six of the Blue Jays' last seven day games.
• Anthony Santander has scored at least one run in each of his last four appearances against the Guardians after playing the previous day.
• Vladimir Guerrero Jr. has recorded at least one Single in 11 of the Blue Jays' last 12 home games against AL Central opponents that held a winning record.
• Alejandro Kirk has recorded at least one hit in each of his last 11 appearances in day games against teams that held a winning record.
• George Springer ranks 4th amongst qualified players for On Base Percentage (.426) this season.

Total Runs Facts

• Each of the Blue Jays' last six day games against American League opponents have gone OVER the total runs line.
• Four of the Guardians' last five games against AL East opponents have gone OVER the total runs line.

Cleveland Guardians vs. Toronto Blue Jays Prediction

I’m on the over in this game. Bibee has allowed 13 runs in his last two road starts, and I think the Blue Jays’ bats can get to him, and this Guardians bullpen has not been as effective as we’re used to them being in years past. On the other side, Francis has had a serious issue with home runs this season and giving them up, and I think the Guardians could go yard a few times here. Give me the over in this one.