Milwaukee Brewers vs St. Louis Cardinals Prediction 4/27/25 MLB Picks

St. Louis Cardinals (12-15) vs Milwaukee Brewers (13-15)

Game Info: Sunday, April 27, 2025 at 2:15 pm (Busch Stadium)

J. Quintana (L) vs E. FEDDE (R)

Betting Odds: St. Louis Cardinals -112 / Milwaukee Brewers -108 --- Over/Under: 8 Click Here for the Latest Odds

Where to Watch: MLB.TV

The Milwaukee Brewers and the St. Louis Cardinals meet Sunday in MLB action from Busch Stadium. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Milwaukee Brewers vs. St. Louis Cardinals prediction.

Starting Pitching Matchup

The Milwaukee Brewers will start Jose Quintana here, and Quintana is 3-0 with a 0.96 ERA and 9 strikeouts this season. In his last five starts against the Cardinals, Quintana is 1-1 with a 4.32 ERA and 22 strikeouts. Erick Fedde will get the start for the Cardinals and is 1-2 with a 3.33 ERA and 13 strikeouts this season. In his last five starts against the Pirates, Fedde is 2-2 with a 5.00 ERA and 20 strikeouts.

Milwaukee Brewers Recap

The Milwaukee Brewers come into this game looking to bounce back from a 6-5 loss at the hands of the Cardinals in Saturday’s matchup to fall to 13-15 on the year. After this series, the Brewers will head on the road for a series against the Chicago White Sox.

Brewers Drop Four In A Row

Brice Turang has a team-high 36 hits with 3 home runs, 14 RBIs, and 8 stolen bases, while Jackson Chourio has 33 hits with a team-high 10 doubles, 6 home runs, and 23 RBIs, and Sal Frelick has 30 hits as well as 7 stolen bases so far this season. Christian Yelich also has 5 stolen bases with 5 homers and 21 RBIs while also adding 3 doubles. Chourio also has a team-high 29 strikeouts up to this point in the year. William Contreras has 3 homers and 15 RBIs as well this season.

Why the Milwaukee Brewers will win

  • The Cardinals have lost six of their last seven games as favorites against the Brewers following a win.
  • The Brewers have won 10 of their last 12 games as road underdogs against NL Central opponents following a road loss.
  • The Brewers have covered the run line in each of their last 12 games as road underdogs against NL Central opponents following a road loss.
  • The Cardinals have failed to cover the run line in each of their last seven games as favorites against the Brewers following a win.

Milwaukee Brewers Player Prop Facts

  • Jackson Chourio has hit a home run in three of his last four appearances against the Cardinals after playing the previous day.
  • Jackson Chourio has recorded a Double in each of the Brewers' last four games against the Cardinals.
  • Jackson Chourio has recorded at least one RBI in five of the Brewers' last six day games against opponents that held a losing record.
  • Jackson Chourio has scored at least one run in each of the Brewers' last seven games against NL opponents that held a losing record.
  • William Contreras has recorded a Single in each of his last 11 appearances with the Brewers as underdogs.
  • Jose Quintana has recorded four or more strikeouts in each of his last nine appearances with his team as an underdog against NL Central opponents.
  • William Contreras has recorded at least one hit in each of his last 13 road appearances.
  • Jose Quintana has recorded a win in each of his last three appearances against opponents that held a losing record.
  • Brice Turang ranks T2nd in the league in Hits (36) this season.

St. Louis Cardinals Recap

The St. Louis Cardinals will be out to add on to their narrow win over the Brew Crew on Saturday to improve to 12-15 on the year. After this set, the Cardinals will head on the road for a series against the Cincinnati Reds.

Cardinals Looking To Complete The Sweep

Brendan Donovan has a team-high 36 hits along with 8 doubles, 3 home runs, and 15 RBIs, while Lars Nootbaar has 26 hits with 4 home runs, 17 RBIs, and 3 stolen bases. Nolan Arenado also has 25 hits with 8 doubles, 3 home runs, and 12 RBIs of his own, and Victor Scott II has 23 hits with 5 doubles, a triple, 10 RBIs, and a team-high 9 stolen bases. Ivan Herrera’s also added a team-high 4 home runs and 11 RBIs so far this season.

Why the St. Louis Cardinals will win

  • The home team has won nine of the Cardinals' last 10 games.
  • The Brewers have lost seven of their last eight road games.

St. Louis Cardinals Player Prop Facts

  • Willson Contreras has hit a home run in two of his last three appearances at Busch Stadium against NL opponents that held a losing record.
  • Brendan Donovan has recorded a Double in four of the Cardinals' last five home games against NL Central opponents that held a losing record.
  • Brendan Donovan has recorded at least one RBI in each of the Cardinals' last four home games against NL Central opponents.
  • Lars Nootbaar has scored at least one run in each of the Cardinals' last six games as home favorites.
  • Brendan Donovan has recorded at least one Single in each of his last nine appearances in day games against teams that held a losing record.
  • Erick Fedde has recorded four or more strikeouts in three of his four previous home appearances against NL Central opponents that held a losing record.
  • Brendan Donovan has recorded at least one hit in each of his last 15 appearances against opponents that held a losing record.
  • Brendan Donovan ranks T2nd in the league in Hits (36) this season.

Total Runs Facts

  • Twelve of the Cardinals' last 14 home games against National League opponents have gone UNDER the total runs line.
  • Each of the Brewers' last three day games after playing the previous day have gone OVER the total runs line.

Milwaukee Brewers vs. St. Louis Cardinals Prediction

I’m on the Brewers here. I’m not sold on Erick Fedde right now, as he’s been hit hard by a lot of teams so far this season and has given up a lot of sharp contact. The Brewers are a better team than what they’ve shown in this series, and it’s only a matter of time before Milwaukee really starts to figure out the road woes that they’ve been having for the better part of the season. I think Milwaukee salvages something from this series and gets the win on Sunday. Give me the Brewers.

Chris’s Pick Milwaukee Brewers -108

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The pick in this article is the opinion of the writer, not a PickDawgz site consensus.

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