Chicago White Sox vs Athletics Prediction 4/26/25 MLB Picks

White Sox Drop Another Series Opener

Lenyn Sosa leads the White Sox with 22 hits, including 3 doubles and 6 RBIs. Andrew Benintendi has 15 hits, including 4 home runs, 9 RBIs, and a .246 batting average, while Miguel Vargas has a team-high 5 doubles and 7 RBIs. Brooks Baldwin has also added 10 RBIs, while Luis Robert Jr. has a team-high 7 stolen bases so far this season. Nick Maton also has a pair of home runs for the White Sox, while Andrew Vaughn has 3 home runs and 10 RBIs as well this season.

Why the Chicago White Sox will win

• The Athletics have lost each of their last six day games following a home win.
• The Athletics have failed to cover the run line in nine of their last 10 home games against teams that held a losing record.
• The White Sox have covered the run line in seven of their last eight day games against AL West opponents.

Chicago White Sox Player Prop Facts

• Andrew Benintendi has hit a home run in three of his last five appearances against the Athletics after playing the previous day.
• Andrew Benintendi has recorded at least one RBI in six of the White Sox's last seven road games against the Athletics.
• Andrew Benintendi has recorded a Single in four of the White Sox's last five games.
• Andrew Vaughn has recorded at least one hit in nine of his last 10 appearances against the Athletics.
• Korey Lee has scored a run in each of his last three appearances against AL West opponents.

Athletics Recap

The Athletics will be looking to add on to their win from Friday’s opening matchup to improve to 13-13 on the year. After this series, the Athletics will head on the road for a rematch series against the Texas Rangers.

Athletics Win Three In A Row

Jacob Wilson leads the Athletics with 31 hits, 6 doubles, and a .330 batting average, while Tyler Soderstrom has 28 hits with 9 home runs and 21 RBIs this season. Brent Rooker has 24 hits with 7 home runs and 13 RBIs, but also has a team-high 30 strikeouts this season, while Max Muncy has 21 strikeouts. Lawrence Butler also chipped in 5 stolen bases and 6 doubles as part of his 26 hits.

Why the Athletics will win

• The White Sox have lost each of their last nine day games against AL West opponents following a loss.
• The Athletics have won each of their last four games against AL Central opponents that held a losing record.
• The Athletics have covered the run line in seven of their last eight games against American League opponents after playing the previous day.
• The White Sox have failed to cover the run line in each of their last five day games against the Athletics following a loss.

Athletics Player Prop Facts

• Lawrence Butler has hit a home run in three of the Athletics' last four games as favorites.
• Brent Rooker has scored at least one run in five of the Athletics' last six games against the White Sox.
• Brent Rooker has recorded at least one hit in each of the Athletics' last nine games against the White Sox.
• Zack Gelof has recorded at least one Single in each of his last six appearances with the Athletics as favorites against AL Central opponents.
• Zack Gelof has recorded an RBI in five of his last six appearances with the Athletics as favorites against AL Central opponents.
• Tyler Soderstrom ranks T1st in the league in Home Runs (9) this season.

Total Runs Facts

• Five of the Athletics' last six home games after playing the previous day have gone UNDER the total runs line.
• Fourteen of the White Sox's last 17 day games against AL West opponents have gone UNDER the total runs line.

Chicago White Sox vs. Athletics Prediction

I’m on the Athletics here. Jeffrey Springs hasn’t had the best start to the season and hasn’t really looked like the prized acquisition that the Athletics were hoping to add to their starting rotation. However, Springs is a lefty, and if there’s one real issue that the Chicago White Sox have had this season, it’s been hitting against left-handed pitching, as the White Sox remain one of the worst teams in baseball in that department so far this season. The Athletics still have a solid lineup and showed that on Friday in the opener, and let the run line cover get away late, but I think the White Sox’s struggles against lefties make this hard to keep this one close. Give me the Athletics -1.5 here.