Orioles vs Nationals Prediction 4/23/25 MLB Picks

In this article, we will formulate an Orioles vs Nationals prediction for this MLB game on Wednesday, April 23rd at Nationals Park in Washington, DC. Let’s take a look at the prediction for this MLB matchup. 

Baltimore Orioles Betting Preview

The Baltimore Orioles are 9-13 this year after they lost game one in this series by a score of 7-0 on Tuesday night. Baltimore fell behind 3-0 in the second inning, and they couldn’t find any offense to get back into the game in the loss. The Orioles recorded just one hit, and they committed one error in the game, while they were led by Mullins, who had their only hit in the loss. Baltimore started Kremer, who allowed 11 hits and five earned runs over 5.1 innings in the loss, while Bowman allowed two hits and one earned run in 1.2 innings of relief work. 

Prior to this series, the Orioles lost two out of three against the Reds, but did win two out of three against the Guardians before that. Baltimore has lost three of their last four games, and they are currently last in the AL East standings. The Baltimore pitching staff has a 5.48 ERA with a 1.61 WHIP and a .300 opponent batting average, while their offense has scored 98 runs with a .224 batting average and a .297 on-base percentage this season. Cedric Mullins has led Baltimore with six home runs and 19 RBIs, while Heston Kjerstad has added three home runs and 12 RBIs this year. The projected starting pitcher for Baltimore is Tomoyuki Sugano, who is 2-1 with a 3.43 ERA and a 1.29 WHIP over 21.0 innings pitched this year. 

Washington Nationals Betting Preview

The Washington Nationals are 10-13 this season after they won the first game in this series on Tuesday night. Washington led 3-0 early in the game, and they added two more runs in the fifth to pull away for the easy win. The Nationals recorded 14 hits in the game, and they were led by Lowe and Ruiz, who both had two RBIs in the win. Washington started Parker, who allowed just one hit over 8.0 innings, while Poche and Henry pitched the final three outs in the game. 

Prior to this series, the Nationals won two out of three against the Rockies, but did lose three out of four against the Pirates before that. Washington has won three of their last four games, and they are currently fourth in the NL East standings. The Washington pitching staff has a 4.88 ERA with a 1.43 WHIP and a .256 opponent batting average, while the offense has scored 100 runs with a .237 batting average and a .308 on-base percentage this season. James Wood has led Washington with seven home runs and 17 RBIs, while Nathaniel Lowe has added four home runs and 19 RBIs this year. The projected starting pitcher for Washington is Trevor Williams, who is 1-2 with a 5.95 ERA and a 1.63 WHIP over 19.2 innings pitched this season. 

Why the Orioles will beat the Nationals 

• The Orioles have won each of their last six Wednesday night games against the Nationals.
• The Nationals have lost six of their last seven games against AL East opponents following a win.
• The Nationals have failed to cover the run line in five of their last six games as underdogs against AL East opponents following a win.
• The Orioles have covered the run line in five of their last six road games following a road loss.

Total Runs Facts

• Each of the Nationals’ last eight games against AL East opponents have gone UNDER the total runs line.
• Six of the Orioles’ last seven games as road favorites have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in eight of the Orioles’ last nine road games.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in six of the Nationals’ last seven games at Nationals Park.

Washington Nationals Player Prop Facts

• Josh Bell has hit a home run in three of his last four appearances against the Orioles after playing the previous day.
• Keibert Ruiz has recorded at least one Double in four of his last five home appearances against opponents that held a losing record.
• Trevor Williams has recorded a win in three of his last four home appearances.
• Luis Garcia has recorded at least one RBI in each of the Nationals’ last four games at Nationals Park against AL East opponents that held a losing record.
• Trevor Williams has recorded five or more strikeouts in each of his last four appearances at Nationals Park.
• Keibert Ruiz has recorded a Single in each of his last six appearances with the Nationals as underdogs against AL opponents.
• Keibert Ruiz has recorded at least one hit in 16 of his last 17 home appearances.
• CJ Abrams has scored at least one run in seven of his last eight home appearances against AL opponents that held a losing record.

Baltimore Orioles Player Prop Facts

• Ryan O’Hearn has hit a home run in three of his last five appearances in night games.
• Ryan O’Hearn has scored a run in five of his last six road appearances.
• Cedric Mullins has recorded a Single in each of the Orioles’ last five road games against NL opponents that held a losing record.
• Ramon Laureano has recorded at least one hit in each of his last 11 appearances in night games against NL teams that held a losing record.
• Colton Cowser has recorded at least one RBI in five of his last six appearances with the Orioles as favorites against NL East opponents.

Orioles vs Nationals Prediction 

Baltimore comes into this matchup really struggling over their last two games, as they have been outscored 31-2 in those two losses. The Orioles have the worst team ERA in the MLB, but they are starting Sugano, who has been one of their best pitchers to start the season. Washington has some momentum after winning three of their last four games, but they are going with Williams, who has a very elevated WHIP on the year. I think this is a great spot for Baltimore to bounce back, and I like them to get the win behind a strong outing from Sugano.