Milwaukee Brewers vs San Francisco Giants Prediction 4/23/25 MLB Picks

The Milwaukee Brewers and the San Francisco Giants meet Wednesday in MLB action from Oracle Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Milwaukee Brewers vs. San Francisco Giants prediction.

Starting Pitching Matchup

The Milwaukee Brewers will send Freddy Peralta for the start here, and Peralta is 2-1 with a 1.91 ERA and 33 strikeouts this season. In his career, Peralta is 1-1 with a 3.48 ERA and 15 strikeouts against the Giants. Logan Webb will get the start for the Giants and is 2-1 with a 2.40 ERA and 38 strikeouts this season. In his last five starts against the Brewers, Webb is 2-1 with a 2.61 ERA and 39 strikeouts.

Milwaukee Brewers Recap

The Milwaukee Brewers come into this game looking to build off of their 11-3 beatdown win over the Giants in Tuesday’s matchup to improve to 13-11 on the year. After this series, the Brewers will head on the road for a series against the Cardinals.

Brewers Even Series Up At One Win Apiece

Brice Turang has a team-high 28 hits with 3 home runs, 11 RBIs, and 8 stolen bases, while Jackson Chourio has 26 hits with a team-high 8 doubles, 5 home runs, and 19 RBIs, and Sal Frelick has 27 hits as well as 7 stolen bases so far this season. Christian Yelich also has 5 stolen bases with 4 homers and 15 RBIs, while Isaac Collins has added 3 doubles. Chourio also has a team-high 25 strikeouts up to this point in the year. William Contreras has 3 homers and 13 RBIs as well this season.

Why the Milwaukee Brewers will win

• The Giants have lost eight of their last nine night games at Oracle Park following a home loss.
• The Brewers have won eight of their last 12 games as underdogs following a road win.
• The Brewers have covered the run line in each of their last five games as underdogs against National League opponents following a road win.
• The Giants have failed to cover the run line in five of their last six night games against NL Central opponents.

San Francisco Giants Recap

The San Francisco Giants will be looking to rebound from their loss at the hands of the Brew Crew in Tuesday’s tilt to fall to 15-9 on the year. After this series, the Giants will welcome the Texas Rangers to town.

Giants Looking To Win Rubber Match

Jung Hoo Lee leads the Giants with 28 hits, including a team-high 10 doubles along with a pair of triples, 3 home runs, and 15 RBIs with 3 stolen bases, while Heliot Ramos has 21 hits with 7 doubles, 3 home runs, and 9 RBIs. Wilmer Flores also has a team-high 7 home runs and 24 RBIs, while Mike Yastrzemski has 3 home runs with 11 RBIs and 6 doubles, and Tyler Fitzgerald has a team-high 5 stolen bases as well on the year.

Why the San Francisco Giants will win

• The Giants have won eight of their last nine games against NL Central opponents following a home loss.
• The Brewers have lost each of their last four games at Oracle Park following a win.
• The Giants have covered the run line in each of their last four home games against the Brewers following a loss.

Total Runs Facts

• Six of the Giants’ last seven games against National League opponents have gone OVER the total runs line.
• Three of the Brewers’ last four night games after playing the previous day have gone UNDER the total runs line.

Milwaukee Brewers vs. San Francisco Giants Prediction

I’m on the Giants in this one. I get the case to be made for the Brewers after looking so dominant at the plate on Tuesday, but that was against Jordan Hicks, a starter I’m not a fan of and a pitcher that throws so hard, he gasses himself out too early and loses control, just like he did in Tuesday’s game. That shouldn’t be a problem with Logan Webb, who goes 6-7 innings on the regular, and I trust the Giants’ bullpen to bounce back here and help San Fran take the series lead with a win. Give me the Giants here.