Los Angeles Dodgers vs Chicago Cubs Prediction 4/23/25 MLB Picks

Chicago Cubs (15-10) vs Los Angeles Dodgers (16-8)

Game Info: Wednesday, April 23, 2025 at 7:00 pm (Wrigley Field)

Matthew Boyd (L) vs ()

Betting Odds: Chicago Cubs -110 / Los Angeles Dodgers -110 --- Over/Under: 8 Click Here for the Latest Odds

Where to Watch: MLB Net

The Los Angeles Dodgers and the Chicago Cubs meet Wednesday in MLB action from Wrigley Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Los Angeles Dodgers vs. Chicago Cubs prediction.

Starting Pitching Matchup

The Los Angeles Dodgers did not have a starting pitcher announced at the time that this article was posted. The Chicago Cubs will send out Matthew Boyd for the start, and Boyd is 1-2 with a 2.01 ERA and 20 strikeouts this season. In his career, Boyd is 1-1 with a 3.00 ERA and 13 strikeouts against the Dodgers.

Los Angeles Dodgers Recap

The Los Angeles Dodgers come into this game looking to bounce back from an 11-10 loss to the Cubs in Tuesday’s matchup to fall to 16-8 on the year. After this series, the Dodgers will head home for a series with the Pittsburgh Pirates.

Dodgers Looking To Rebound

Shohei Ohtani leads the Dodgers with 23 hits, including 6 home runs, while Tommy Edman has 23 hits with a team-high 7 home runs and 15 RBIs. Michael Conforto has 13 hits with 4 doubles, while Teoscar Hernandez has 20 hits with 5 home runs, 4 doubles, and 17 RBIs as well this season. Ohtani has a team-high 5 stolen bases, while Max Muncy has 5 doubles but also has the team lead with 28 strikeouts so far this season. Mookie Betts has also chipped in 4 home runs and 10 RBIs on the year.

Why the Los Angeles Dodgers will win

  • The Dodgers have won each of their last 10 Wednesday games.
  • The Cubs have lost each of their last eight Wednesday games against National League opponents that held a winning record.
  • The Cubs have failed to cover the run line each of their last eight Wednesday games against National League opponents that held a winning record.
  • The Dodgers have covered the run line in 11 of their last 13 night games after going to extra innings.

Los Angeles Dodgers Player Prop Facts

  • Tommy Edman has hit a home run in four of the Dodgers' last five night games against opponents that held a winning record.
  • Max Muncy has recorded at least one RBI in seven of his last eight appearances against the Cubs after playing the previous day.
  • Will Smith has recorded a Double in three of his last four appearances against NL Central opponents.
  • Teoscar Hernandez has recorded at least one hit in each of the Dodgers' last 11 night games against opponents that held a winning record.
  • Will Smith has scored at least one run in each of his last eight Wednesday night appearances.
  • Teoscar Hernandez has recorded at least one Single in each of the Dodgers' last 11 night games against opponents that held a winning record.

Chicago Cubs Recap

The Chicago Cubs come into this game looking to add on to their win over the Dodgers from Tuesday’s matchup to improve to 15-10 on the year. After this series, the Cubs will square off against the Philadelphia Phillies at home.

Cubs Looking For Back-To-Back Series Wins

Kyle Tucker leads the Cubs with 29 hits, including team-highs of 8 doubles, 6 home runs, and 23 RBIs, while Seiya Suzuki also has 22 hits with a pair of doubles and 6 home runs and 18 RBIs of his own. Miguel Amaya added 6 doubles and 12 RBIs, and Pete Crow-Armstrong also has contributed 8 doubles this season. Dansby Swanson has added 4 home runs and 12 RBIs, while he also has the unfortunate distinction of leading the Cubs with 30 strikeouts so far this season. Crow-Armstrong also has a team-high 8 stolen bases, while Nico Hoerner has 6 stolen bases this season. Michael Busch has also chipped in 5 home runs and 16 RBIs this season.

Why the Chicago Cubs will win

  • The Cubs have won seven of their last eight night games after playing the previous day.
  • The Dodgers have lost four of their last five road games against National League opponents.
  • The Cubs have covered the run line in each of their last six night games against the Dodgers following a home win.
  • The Dodgers have failed to cover the run line in each of their last five road games against National League opponents.

Chicago Cubs Player Prop Facts

  • Kyle Tucker has hit a home run in three of the Cubs' last five home games against NL West opponents.
  • Seiya Suzuki has recorded at least one RBI in six of the Cubs' last seven games against the Dodgers at Wrigley Field.
  • Ian Happ has recorded a Double in each of the Cubs' last three games against the Dodgers at Wrigley Field.
  • Matthew Boyd has recorded five or more strikeouts in seven of his last eight appearances against NL opponents.
  • Kyle Tucker has recorded at least one hit in each of his last six appearances against the Dodgers after playing the previous day.
  • Ian Happ has scored at least one run in each of the Cubs' last eight home games.
  • Nico Hoerner has recorded at least one Single in seven of his last eight appearances in night games.

Total Runs Facts

  • Each of the Dodgers' last five road games against National League opponents have gone OVER the total runs line.
  • Each of the Cubs' last four games following an extra innings win have gone UNDER the total runs line.

Los Angeles Dodgers vs. Chicago Cubs Prediction

I’m on the over in this game. I just think this is going to be a higher-scoring game, as maybe the Dodgers have exorcised their demons against left-handed pitching after breaking out offensively on Tuesday, and I think the Cubs can do damage off of this Dodger bullpen if it’s a bullpen game or whoever the Dodgers send out for a spot start. Either way, I’m expecting runs, so give me the over.

The pick in this article is the opinion of the writer, not a PickDawgz site consensus.

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