Chicago White Sox vs Minnesota Twins Prediction 4/22/25 MLB Picks

White Sox Lose Another Series

Lenyn Sosa leads the White Sox with 20 hits, including 3 doubles and 5 RBIs. Andrew Benintendi has 12 hits, including 4 home runs, 8 RBIs, and a .245 batting average, while Miguel Vargas has a team-high 5 doubles and 6 RBIs. Brooks Baldwin has also added 10 RBIs, while Luis Robert Jr. has a team-high 7 stolen bases so far this season. Nick Maton also has a pair of home runs for the White Sox, while Andrew Vaughn has 3 home runs and 10 RBIs as well this season.

Why the Chicago White Sox will win

• The Twins have lost five of their last six games as home favorites following a road loss.
• The underdogs have won 10 of the Twins' last 13 games at Target Field.
• The White Sox have covered the run line in each of their last eight Tuesday night games as road underdogs against AL Central opponents.
• The Twins have failed to cover the run line in each of their last five night games at Target Field following a road loss.

Chicago White Sox Player Prop Facts

• Andrew Benintendi has hit at least one home run in three of his last seven road appearances against opponents that held a losing record.
• Andrew Benintendi has recorded at least one Single in each of his last four appearances against AL Central opponents that held a losing record.
• Andrew Benintendi has recorded at least one hit in each of his last seven appearances against AL Central opponents that held a losing record.
• Mike Tauchman has recorded at least one RBI in each of his three previous road appearances against the Twins.
• Mike Tauchman has scored at least one run in five of his last six appearances against the Twins.
• Luis Robert ranks T6th in the league in Steals (7) this season.

Minnesota Twins Recap

The Minnesota Twins come into this game looking to bounce back after being swept by the Atlanta Braves over the weekend, following a 6-2 loss in Sunday’s series finale to fall to 7-15 on the year. After this series, the Twins will welcome the Los Angeles Angels to town for a series.

Twins Drop Three Straight

Byron Buxton leads the Twins with 19 hits, along with 4 doubles, a team-high 4 home runs, and 10 RBIs with 5 stolen bases, while Carlos Correa has 14 hits with 6 doubles, and Willi Castro has 15 hits with 6 doubles as well. Harrison Bader added 3 home runs and a team-high 12 RBIs while Matt Wallner chipped in 5 doubles and a pair of triples, while Buxton contributed a team-high 26 strikeouts as well this season.

Why the Minnesota Twins will win

• The White Sox have lost each of their last 15 night games against AL Central opponents.
• The Twins have won each of their last 12 home games against the White Sox.
• The White Sox have failed to cover the run line in 11 of their last 12 games at Target Field against teams that held a losing record.
• The Twins have covered the run line in seven of their last eight home games against AL Central opponents that held a losing record.

Minnesota Twins Player Prop Facts

• Carlos Correa has recorded a Double in three of his last four appearances with the Twins as favorites against AL Central opponents.
• Byron Buxton has hit a home run in each of his last three home appearances against the White Sox after not playing the previous day.
• Bailey Ober has recorded seven or more strikeouts in each of his last four appearances with the Twins as favorites against AL Central opponents.
• Bailey Ober has recorded a win in five of his last six appearances in night games against AL teams that held a losing record.
• Byron Buxton has recorded at least one RBI in each of his last seven home appearances against the White Sox after not playing the previous day.
• Ryan Jeffers has recorded at least one Single in each of his last eight appearances against the White Sox after not playing the previous day.
• Byron Buxton has scored at least one run in each of his last six appearances against the White Sox after not playing the previous day.
• Willi Castro has recorded at least one hit in each of the Twins' last 11 games as home favorites against AL Central opponents.

Total Runs Facts

• Each of the Twins' last four games as favorites has gone UNDER the total runs line.
• Four of the White Sox's last five night games against AL Central opponents have gone UNDER the total runs line.

Chicago White Sox vs. Minnesota Twins Prediction

I’m on the Twins here. I’m not really rushing to bet this game, as the line is hefty for a Twins team that’s not playing all that well. However, there’s no backing the White Sox right now, and Martin was absolutely smoked when he faced the Twins last year. Ober’s big issue in his career has been giving up home runs, and the White Sox just don’t have the power in their lineup to make Ober pay for any mistakes. I think the Twins get the win here to start the series on the right foot. Give me Minnesota in this one.