San Diego Padres vs Detroit Tigers Prediction 4/21/25 MLB Picks

The San Diego Padres and Detroit Tigers meet Monday in MLB action at Comerica Park. Here’s a San Diego Padres vs Detroit Tigers Prediction. This article will include a San Diego Padres vs Detroit Tigers Pick.

San Diego Padres Betting Preview

The San Diego Padres are 16-6 on the year and play the Rays, Giants, and Pirates next. The San Diego Padres are batting .276 on the season, have a .346 OBP, and a .424 slugging percentage. The San Diego Padres pitching staff has a 2.74 ERA and a 1.09 WHIP. Fernando Tatis Jr. leads the San Diego Padres with 29 hits and 16 RBI, while Luis Arraez and Manny Machado have combined for 50 hits and 17 RBI. 

Randy Vasquez gets the ball for the San Diego Padres, and he is 1-1 with a 1.74 ERA and 8 strikeouts this season. This will be Vasquez’s second career game against the Detroit Tigers.

Detroit Tigers Betting Preview

The Detroit Tigers are 13-9 on the year and play the Orioles, Astros, and Angels next. The Detroit Tigers are batting .246 on the season, have a .321 OBP, and a .387 slugging percentage. The Detroit Tigers’ pitching staff has a 3.12 ERA and a 1.14 WHIP. Kerry Carpenter leads the Detroit Tigers with 23 hits and 11 RBI, while Spencer Torkelson and Riley Greene have combined for 42 hits and 29 RBI.

Keider Montero gets the ball for the Detroit Tigers, and he is 0-1 with a 9.00 ERA and 8 strikeouts this season. This will be Montero’s second career game against the San Diego Padres.

Why the Detroit Tigers will win

• The Tigers have won five of their last six games at Comerica Park following a loss.
• The Padres have lost five of their last six road games against American League opponents following a win.
• The Tigers have covered the run line each of their last six games at Comerica Park against teams that held a winning record.
• The Padres have failed to cover the run line in each of their last six road games following a win.
• The Padres have trailed after 5 innings in six of their last seven road games against opponents that held a winning record.

Why the San Diego Padres will win

• The Padres have won each of their last six games against AL Central opponents.
• The Tigers have lost five of their last six games as home favorites following an extra-innings loss.
• The Tigers have failed to cover the run line in each of their last seven games as favorites following an extra-innings loss.
• The Padres have covered the run line in seven of their last eight games after playing the previous day.
• The Tigers have trailed after 5 innings in three of their last four home games against National League opponents that held a winning record.

Detroit Tigers Player Prop Facts

• Riley Greene has recorded at least one Double in three of the Tigers’ last four games at Comerica Park against NL West opponents that held a winning record.
• Spencer Torkelson has recorded at least one RBI in seven of the Tigers’ last eight games as favorites.
• Spencer Torkelson has recorded at least one Single in each of his last seven appearances with the Tigers as favorites against NL West opponents.
• Javier Baez has hit a home run in four of his last six appearances with his team as a favorite against the Padres.
• Javier Baez has scored at least one run in each of his last six appearances with his team as a home favorite against the Padres.
• Parker Meadows has recorded at least one hit in each of his last 13 appearances in night games.
• Spencer Torkelson ranks 7th amongst qualified players for Slugging Percentage (.637) this season.

San Diego Padres Player Prop Facts

• Xander Bogaerts has recorded at least one Double in each of the Padres’ last three games as underdogs against AL opponents.
• Fernando Tatis Jr. has recorded an RBI in each of his last four road appearances against AL Central opponents that held a winning record.
• Fernando Tatis Jr. has scored a run in each of his last five road appearances against AL opponents that held a winning record.
• Luis Arraez has recorded at least one Single in 14 of his last 15 road appearances against AL opponents that held a winning record.
• Luis Arraez has recorded at least one hit in each of his last 15 road appearances against AL Central opponents.
• Martin Maldonado has hit a home run in each of his last three appearances against AL opponents that held a winning record.
• Fernando Tatis Jr. ranks 3rd amongst qualified players for Batting Average (.358) this season.

San Diego Padres vs Detroit Tigers Prediction

The Padres continue to be one of the more consistent teams in baseball, and they’re throwing out Vazquez, who has been fantastic so far. In 20.2 innings, Vazquez has allowed 14 hits and four earned runs, and that’s with walking 14. Vazquez has dealt with a lot of traffic this season, but it hasn’t mattered much. Montero hasn’t been great through 17 career starts, as he has a 4.96 ERA and 1.35 WHIP, and he was rocked in his first start this season. It’s wild that we’re getting the Padres as a dog in this spot, but I’m not asking any questions. Give me the Padres.