Milwaukee Brewers vs San Francisco Giants Prediction 4/21/25 MLB Picks

San Francisco Giants (14-8) vs Milwaukee Brewers (12-10)

Game Info: Monday, April 21, 2025 at 9:45 pm (Oracle Park)

Q. Priester (R) vs R. Ray (L)

Betting Odds: San Francisco Giants -148 / Milwaukee Brewers +124 --- Over/Under: 8 Click Here for the Latest Odds

Where to Watch: MLBN

In this article, we will formulate a Brewers vs Giants prediction for this MLB game on Monday, April 21, at Oracle Park in San Francisco, California. Let’s take a look at the prediction for this MLB matchup.

Milwaukee Brewers Betting Preview

The Milwaukee Brewers (12-10, 3-6 Away) lost the series to the Arizona Diamondbacks on the road, but then returned home and beat the Detroit Tigers and Athletics. Now, the Brewers will spend the next three series on the road. In the latest 14-1 victory over the A's, Rhys Hoskins led the team with four RBI, while Logan Henderson got the win after allowing one run on three hits with nine strikeouts and one walk in 6.0 innings of work.

This season, the Brewers average 5.09 runs per game (5th in the MLB) on a .240/.312/.379 slash line. Regarding pitching, the Brewers’ staff has a 4.16 ERA (19th) and 1.28 WHIP (16th). Jackson Chourio leads the Brewers with a .260 batting average, five home runs, and 19 RBI this season.

The projected starting pitcher for the Brewers is Quinn Priester, who is 1-0 in two starts this season, with a 0.90 ERA and 1.20 WHIP in 10.0 innings.

San Francisco Giants Betting Preview

The San Francisco Giants (14-8, 4-2 Home) are back home from a road trip during which they faced the Yankees, Phillies, and Angels. After defeating the Yankees, the Giants split the series with the Phillies and lost to the Angels. In the most recent 5-4 loss to the Angels, Willy Adames and Sam Huff contributed two RBI apiece, while Justin Verlander pitched for 6.0 innings in a no-decision, allowing one run on two hits with six strikeouts and two walks. Ryan Walker took the loss.

This year, the Giants average 5.05 runs per game (6th in the MLB) on a .224/.305/.395 triple-slash. When it comes to pitching, the Giants’ staff has a 3.53 ERA (6th) and 1.22 WHIP (12th). Wilmer Flores leads the Giants with a .203 batting average, six home runs, and 23 RBI this season.

Robbie Ray will take the mound for the Giants on Monday. The 33-year-old left-hander has a 3-0 record in four starts this year with a 4.19 ERA and 1.55 WHIP in 19.1 innings.

Why the Giants will beat the Brewers

  • The Brewers have lost each of their last 10 Monday night road games.
  • The Giants have won six of their last seven home games following a road loss.
  • The Brewers have failed to cover the run line in each of their last eight Monday night road games against National League opponents.
  • The Giants have covered the run line each of their last six Monday games against teams that held a winning record.
  • The Giants have led after 3 innings in three of their last four night games against National League opponents that held a winning record.

Total Runs Facts

  • Nine of the Giants' last 11 games have gone OVER the total runs line.
  • Three of the Brewers' last four games against NL West opponents have gone UNDER the total runs line.
  • The 'Inning 1 UNDER 0.5 runs' market has hit in seven of the Brewers' last eight night games against National League opponents.
  • The 'Inning 1 UNDER 0.5 runs' market has hit in each of the Giants' last four games as favorites against NL Central opponents.

Matchup/League Facts

  • The Giants rank T5th in the league for runs allowed this season (81).
  • The Giants rank 6th in the league for runs scored this season (111).
  • The Brewers rank 5th in the league for runs scored this season (112).
  • The Brewers rank T6th in the league for triples this season (4).

Brewers vs Giants Prediction

The teams have traded victories in the past few years, as each recorded five in the previous ten H2H duels. Milwaukee did win four of the last five H2Hs, but I am backing the Giants in this one because I don't trust Quinn Priester on the mound for the Brewers. Priester allowed just one earned run in 10.0 innings this season, but I believe it's time for him to be really tested, and the Giants are one of the higher-scoring teams in the MLB. Robbie Ray, on the other hand, didn't have the best start against the Phillies last time out, and I am backing him to bounce back in this one. The Brewers have a .235 BA against southpaws this year. Go with San Francisco.

Oliver’s Pick Giants ML

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The pick in this article is the opinion of the writer, not a PickDawgz site consensus.

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