Athletics vs Chicago White Sox Prediction 4/16/25 MLB Picks

Chicago White Sox (4-12) vs Athletics (7-10)

Game Info: Wednesday, April 16, 2025 at 7:40 pm (Rate Field)

O. Bido (R) vs J. Cannon (R)

Betting Odds: Chicago White Sox +130 / Athletics -155 --- Over/Under: 7.5 Click Here for the Latest Odds

Where to Watch: MLB.TV

The Athletics and the Chicago White Sox meet Wednesday in MLB action from Rate Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s an Athletics vs. Chicago White Sox prediction.

Starting Pitching Matchup

The Athletics will send out Osvaldo Bido for the start here, and Bido is 1-1 with a 3.00 ERA and 14 strikeouts this season. This will be Bido’s first career start against the White Sox. The Chicago White Sox will start Jonathan Cannon here, and Cannon is 0-2 with a 5.79 ERA and 14 strikeouts this season. This will be Cannon’s second career start against the Athletics.

Athletics Recap

The Athletics will be out to build on their series-opening 12-3 win over the White Sox on Tuesday to improve to 7-10 on the year. After this series, the Athletics will head on the road for a series against the Milwaukee Brewers.

Athletics Looking For Some Consistency After Splitting Last Ten Games

Jacob Wilson leads the Athletics with 22 hits, 4 doubles, and a .333 batting average, while Tyler Soderstrom has 21 hits with 8 home runs and 17 RBIs this season. Brent Rooker has 15 hits with 4 home runs and 8 RBIs but also has a team-high 22 strikeouts this season, while Max Muncy has 16 strikeouts. Lawrence Butler also chipped in a pair of stolen bases and 4 doubles as part of his 18 hits.

Why the Athletics will win

  • The White Sox have lost nine of their last 10 home games against AL West opponents following a home loss.
  • The road team has won four of the Athletics' last five games.
  • The Athletics have covered the run line in each of their last four games against American League opponents.
  • The White Sox have failed to cover the run line in four of their last five home games against teams that held a losing record.

Athletics Player Prop Facts

  • Gio Urshela has recorded a Double in each of his last three appearances with his team as a road favorite.
  • Shea Langeliers has hit a home run in each of the Athletics' last three night games against opponents that held a losing record.
  • Gio Urshela has recorded at least one RBI in each of his last four appearances with his team as a road favorite.
  • Shea Langeliers has scored at least one run in each of his last four road appearances.
  • Lawrence Butler has recorded at least one hit in each of the Athletics' last 15 night games against opponents that held a losing record.
  • Zack Gelof has recorded at least one Single in each of his last six appearances with the Athletics as favorites against AL Central opponents.
  • Tyler Soderstrom ranks 1st in the league in Home Runs (8) this season.

Chicago White Sox Recap

The Chicago White Sox come into this game looking to rebound after a blowout loss at the hands of the Athletics in Tuesday’s series opener to fall to 4-12 on the year. After this series, the White Sox will head on the road for a series against the Boston Red Sox.

White Sox Drop Back-To-Back Games

Lenyn Sosa leads the White Sox with 12 hits, including a pair of doubles and 5 RBIs. Andrew Benintendi has 9 hits, including 2 home runs, 6 RBIs, and a .290 batting average, while Miguel Vargas has a team-high 4 doubles and 6 RBIs. Brooks Baldwin has also added 7 RBIs while Luis Robert Jr. has a team-high 6 stolen bases so far this season. Nick Maton also has a pair of home runs for the White Sox, while Andrew Vaughn has a team-high 2 home runs and 8 RBIs as well this season.

Why the Chicago White Sox will win

  • The Athletics have lost each of their last six games as favorites against AL Central opponents following a win.
  • The White Sox have won five of their last seven games as home underdogs against the Athletics.
  • The Athletics have failed to cover the run line in each of their last six games as favorites against AL Central opponents following a win.
  • The White Sox have covered the run line in eight of their last nine games as home underdogs against AL West opponents.

Chicago White Sox Player Prop Facts

  • Andrew Vaughn has recorded at least one RBI in four of his last five appearances with the White Sox as home underdogs against the Athletics.
  • Luis Robert has scored at least one run in six of his seven previous home appearances against the Athletics after playing the previous day.
  • Andrew Benintendi has hit a home run in three of his last five appearances with the White Sox as underdogs against the Athletics.
  • Andrew Benintendi has recorded at least one hit in each of his last 11 home appearances against opponents that held a losing record.
  • Andrew Benintendi has recorded at least one Single in each of his last six home appearances against AL West opponents that held a losing record.
  • Luis Robert ranks T4th in the league in Steals (6) this season.

Total Runs Facts

  • Each of the Athletics' last five night games after playing the previous day have gone OVER the total runs line.
  • Eight of the White Sox's last 10 games as underdogs against the Athletics have gone UNDER the total runs line.

Athletics vs. Chicago White Sox Prediction

I’m on the Athletics in this one. I’m all about making a case for an underdog in certain spots, but the Athletics for me are just the better team playing some solid baseball out of the gate, and while I’m not the biggest Osvaldo Bido fan, he’s the better option here. The Athletics offense can be boom or bust, but as we saw on Tuesday, when the bats are clicking, the Athletics have a lot of upside. I think the Athletics grab another one here so give me the Athletics on the road here.

Chris’s Pick Athletics -155

Get Premium Picks Start Winning Now »
The pick in this article is the opinion of the writer, not a PickDawgz site consensus.

18+ Has gambling become a problem for you? Call the National Problem Gambling Hotline.
1-800-522-4700 | ncpgambling.org

Credit Guaranteed Packages

Packages with Credit Guarantees automatically give you a credit if the package does not turn a profit—the sum of betting all individual picks. THESE ARE NOT PARLAYS UNLESS OTHERWISE CLEARLY STATED. If a credit guaranteed package does not profit, a credit for its full purchase price is automatically issued after picks are graded and verified.

For example, if you purchase a $39.95 package that doesn’t profit, you’ll get a $39.95 credit towards any future purchase(s) on our site. Credits are usually issued within hours of a game’s conclusion, so please allow a few hours for final verification.

To use your credits, log in to your account and add another package or pass to your cart. Credits will automatically reduce what you owe. Any remaining balance will be settled through our payment system, with any leftover credits available future purchases. Credits do not expire.

Dismiss