Oakland Athletics vs Chicago White Sox Prediction 4/15/25 MLB Picks

Recent betting trends and streaks involving the Chicago White Sox

Recent betting trends and streaks involving the Athletics

Recent betting trends in games played between the Athletics vs Chicago White Sox

A summary that ties it all together and produces a favorable betting outcome for the Athletics vs Chicago White Sox game

Chicago White Sox Preview

The Chicago White Sox have a 4-11 record this season and are sitting in the last place of the AL Central. The White Sox have a 4-5 home record and 6-7 in over/under. They are coming off a 1-3 home defeat by the Boston Red Sox, which ended their previous two-game winning streak. Under is 5-1-1 in their last 7 games. The White Sox have a .201 batting average this season, .272 OBP, and .300 slugging percentage. Chicago’s pitching staff has a 3.55 ERA and 1.28 WHIP.  Brooks Baldwin leads the White Sox with 11 hits and a team-high 7 RBI. Lenyn Sosa leads the team in batting average with .213.

Sean Burke (R) will take the mound for the White Sox, and he has a 1-2 record, 6.08 ERA, and 1.28 WHIP. He has 9 earned runs in just 7.1 innings pitched in his last two starts, and he has never faced the A’s before.   

Oakland Athletics Preview

The Athletics have a 6-10 record this season and are sitting in the last place of the AL West. The Athletics have a 4-3 road record and 8-6 in over/under. They are coming off a 0-8 home defeat by the New York Mets and are 1-3 in their last 4 games. Under is 3-1 in their last 4 games. The Athletics have a .242 batting average this season, .309 OBP, and .400 Slugging percentage. Athletics’ pitching staff has a 4.91 ERA and 1.54 WHIP. Jacob Wilson leads the Athletics with 21 hits and a team-high .344 batting average. Tyler Soderstrom leads the team with 11 RBI and 6 home runs.

Jeffrey Springs (L) will take the mound for the Athletics, and he has a 2-1 record, 4.20 ERA, and 1.47 WHIP. He has 7 earned runs in 9 innings pitched in his last two starts, and he has never faced the White Sox before.  

Why the Chicago White Sox will win

• The Athletics have lost 12 of their last 13 road games against AL Central opponents.
• The White Sox have won five of their last six games as home underdogs against the Athletics.
• The White Sox have covered the run line in each of their last eight games as home underdogs against AL West opponents.
• The Athletics have failed to cover the run line in seven of their last eight games as favorites against American League opponents.
• The Athletics have lost the first inning in three of their last four night games against opponents that held a losing record.
• The Athletics have trailed after 3 innings in each of their last four night games against opponents that held a losing record.
• The Athletics have trailed after 5 innings in each of their last four night games against opponents that held a losing record.

Why the Athletics will win

• The Athletics have won each of their last five games against the White Sox following a home loss.
• The White Sox have lost 24 of their last 27 home games following a home loss.
• The Athletics have covered the run line in each of their last seven night games against AL Central opponents following a loss.
• The White Sox have failed to cover the run line in four of their last five night games following a home loss.
• The Athletics have led after 5 innings in each of their last four games against American League opponents.

Total Runs Facts

• Eight of the Athletics' last nine games as favorites against the White Sox have gone UNDER the total runs line.
• Seven of the White Sox's last eight games against AL West opponents have gone UNDER the total runs line.
• The 'Inning 1 UNDER 0.5 runs' market has hit in each of the Athletics' last eight games against American League opponents.
• The 'Inning 1 UNDER 0.5 runs' market has hit in each of the White Sox's last seven night games at Rate Field.

Oakland Athletics vs Chicago White Sox Prediction

Both teams were tied 3-3 wins in their 6 meetings last season, and the White Sox won the only series in Chicago by 2-1 wins. Under is 7-1 in their last 8 overall meetings.

In this Athletics vs Chicago White Sox Prediction, the Athletics are coming as -160 road favorites. The A’s have a better record this season, but I simply cannot back them as such big road favorites at this point, especially with a struggling pitcher on the mound. With both starting pitchers having a combined ERA of 10+, and with the A’s having the 5th-worst bullpen ERA in the league, I expect both offenses to wake up. Give me the over 8 runs in this one.