Los Angeles Angels vs Houston Astros Prediction 4/11/25 MLB Picks

Houston Astros Betting Preview

The Houston Astros are 5-7 on the year and play the Cardinals, Padres, and Blue Jays next. The Houston Astros are batting .208 on the season, have a .293 OBP, and a .291 slugging percentage. The Houston Astros' pitching staff has a 3.78 ERA and a 1.07 WHIP. Jose Altuve leads the Houston Astros with 18 hits and 6 RBI, while Isaac Paredes and Brendan Rodgers have combined for 19 hits and 8 RBI.

Ronel Blanco gets the ball for the Houston Astros, and he is 0-1 with a 9.45 ERA and 9 strikeouts this season. Blanco is 3-0 with a 2.33 ERA and 22 strikeouts in his career against the Los Angeles Angels.

Why the Houston Astros will win

• The Astros have won each of their last 13 Friday games against the Angels.
• The Angels have lost each of their last seven night games against American League opponents following a road win.
• The Astros have covered the run line in 10 of their last 11 home games against AL West opponents following a road loss.
• The Angels have failed to cover the run line in seven of their last eight games against American League opponents following a road win.
• The Angels have trailed after 5 innings in five of their last six games as underdogs against AL West opponents.
• The Astros have led after 3 innings in each of their last three games against the Angels.

Why the Los Angeles Angels will win

• The Astros have lost each of their last six games at Daikin Park against teams that held a winning record.
• The Angels have won four of their last five games as underdogs against American League opponents.
• The Astros have failed to cover the run line each of their last nine games at Daikin Park against teams that held a winning record.
• The Angels have covered the run line in each of their last five games.
• The Angels have led after 3 innings in four of their last five games as road underdogs.
• The Angels have led after 5 innings in four of their last five games at Daikin Park against AL West opponents that held a losing record.

Los Angeles Angels vs Houston Astros Prediction

I’ve bashed the Angels over the years, as this is an underachieving franchise that has ruined careers, but they’ve won eight of their last 12 games and are putting up big numbers offensively. As long as that continues, the Angels are worth a look in the underdog role. The Astros aren’t getting much offense outside of Altuve, and their pitching has been hit hard in these recent losses. Blanco has also been hit hard through 6.2 innings, allowing eight hits and seven runs while walking six. Not sure how you can lay juice with the Astros in this spot. I’ll take a shot with the hot Angels on the road and the more favorable price.