Chicago White Sox vs Cleveland Guardians Prediction 4/10/25 MLB Picks

Cleveland Guardians Betting Preview

The Cleveland Guardians are 5-6 this season after they won game two in this series by a score of 3-2 on Wednesday. Cleveland fell behind early, but they scored three runs in the first three innings of the game and were able to barely escape with the win. The Guardians recorded just three hits, and they committed one error, while they were led by Santana and Noel, who both had one RBI in the win. Cleveland started Allen, who allowed just four hits over 4.2 innings, while Clase allowed one earned run in the ninth but still got the save. 

Prior to this series, the Guardians lost two out of three against the Angels and were swept by the Padres in three games before that. The Cleveland pitching staff has a 4.21 ERA with a 1.47 WHIP and a .264 opponent batting average, while their offense has scored 38 runs with a .204 batting average and a .300 on-base percentage this season. Kyle Manzardo has led Cleveland with three home runs and nine RBIs, while Jose Ramirez has added four home runs and six RBIs this year. The projected starting pitcher for Cleveland is Gavin Williams, who is 0-0 with a 4.50 ERA and a 1.63 WHIP over 8.0 innings pitched this season. 

Why the Guardians will beat the White Sox 

• The White Sox have lost each of their last seven games against American League opponents.
• The Guardians have won each of their last six home games against teams that held a losing record.
• The Guardians have covered the run line in 10 of their last 11 day games against American League opponents following a win.
• The White Sox have failed to cover the run line each of their last six Thursday games against AL Central opponents that held a losing record.
• The White Sox have trailed after 3 innings in four of their last five games against American League opponents that held a losing record.
• The White Sox have trailed after 5 innings in four of their last five games against AL Central opponents that held a losing record.

Why the White Sox will beat the Guardians 

• The Guardians have lost four of their last five games as favorites against the White Sox following a home win.
• The Guardians have failed to cover the run line in each of their last seven home games against the White Sox following a home win.
• The White Sox have covered the run line in seven of their last eight games against American League opponents following a road loss.

Total Runs Facts

• Five of the Guardians' last six home games after playing the previous day have gone UNDER the total runs line.
• Each of the White Sox's last three games against AL Central opponents have gone UNDER the total runs line.
• The 'Inning 1 OVER 0.5 runs' market has hit in six of the White Sox's last seven day games.
• The 'Inning 1 UNDER 0.5 runs' market has hit in six of the Guardians' last seven day games.

Cleveland Guardians Player Prop Facts

• Will Brennan has recorded at least one Double in each of his last three appearances with the Guardians as favorites.
• Steven Kwan has recorded at least one Single in 12 of his last 14 appearances after playing the previous day.
• Carlos Santana has recorded at least one hit in each of his last eight appearances with his team as a home favorite against AL opponents.
• Steven Kwan has scored at least one run in each of his last four appearances against the White Sox after playing the previous day.
• Carlos Santana has hit a home run in four of his last seven appearances with the Guardians as home favorites against the White Sox.
• Lane Thomas has recorded at least one RBI in five of his six previous appearances with his team as a favorite against the White Sox.

Chicago White Sox Player Prop Facts

• Andrew Benintendi has hit at least one home run in three of his last seven road appearances against opponents that held a losing record.
• Andrew Benintendi has recorded at least one Single in eight of his last nine appearances against AL opponents that held a losing record.
• Andrew Benintendi has recorded at least one hit in each of his last nine appearances against AL opponents that held a losing record.
• Korey Lee has scored a run in three of his last four road appearances against AL opponents that held a losing record.

Chicago White Sox vs Cleveland Guardians Prediction 

The White Sox come into this contest looking to snap a lengthy losing streak, but they are still on the road and are dealing with some injuries now. Chicago hasn’t been too bad with their pitching, but they have scored three runs or fewer in four straight games. Cleveland is looking to complete the sweep here, but their offense has also had a slow start to the year. I think these two pitchers are pretty evenly matched, but I am not impressed with either one, and I think each will give up at least three earned runs. Take the over here.