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San Francisco Giants vs Houston Astros Prediction 4/1/25 MLB Picks

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Houston Astros (2-2) vs San Francisco Giants (3-1)

April 1, 2025 at 08:10 PM EDT

The Line: Betting Odds: Houston Astros -102 / San Francisco Giants -118 — Over/Under: 8

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In this article, we will formulate a San Francisco Giants vs Houston Astros Prediction for this MLB game on Tuesday, April 1st, at Minute Maid Park. To formulate this prediction, we will look at: 

-The Giants’ recent form and recent player performance 

-The Astros’ recent form and recent player performance

-Recent Betting trends and streaks involving San Francisco

-Recent Betting trends and streaks involving Houston 

-Recent betting trends in games played between San Francisco and Houston

-A summary that ties it all together produces a favorable betting outcome for Today’s Game between the Giants and Astros. 

Strong Start for the Giants

It has been a strong start for the Giants, and they have come into this game with a 3-1 record overall. The offense really broke out once the Astros bullpen came into the game, and that was enough for the Giants to secure the 7-2 victory. Wilmer Flores was the star of the show for San Francisco, hitting a home run and driving in four RBIs. Jordan Hicks also had a dominant game going six innings giving up one hit, zero runs, and six strikeouts. Saturday was the only loss, and in that game, the pitching was still good, giving up only three runs. Over the last three games, the Giants have given up only eight runs in total. 

Logan Webb, making his second season start, will start for the Giants. He enters this game with a 0-0 record and an ERA of 5.40. Against the Cincinnati Reds, he pitched five innings, giving up six hits and three runs. 

Shocking Pitching for Astros

In the first three games of the season, the Astros’ pitching was strong, but the same couldn’t be said on Monday. Ronel Blanco went five innings and gave up three hits and three runs. Luis Contreras and Rafael Montero were both issues out of the bullpen, and they gave up two runs. Isaac Parades was the only bright spot for the offense, and he finished with one hit and two RBIs driven in. On Saturday, the Astros faced off against the New York Mets, and they picked up the 2-1 victory. 

Hayden Wesneski will start for the Astros, and this will be his first start with his new squad. Last season with the Chicago Cubs, he finished with a 3-6 record and an ERA of 3.86. 

Why the Astros will beat the Giants

  • The Giants have lost each of their last four games as favorites against AL West opponents following a win.
  • The Astros have won four of their last five games as underdogs against NL West opponents following a loss.
  • The Astros have covered the run line in eight of their last nine games against NL West opponents following a loss.
  • The Giants have failed to cover the run line in each of their last four games as favorites against AL West opponents following a win.

Total Runs Facts

  • Seven of the Astros’ last eight games have gone UNDER the total runs line.
  • Each of the Giants’ last four road games after playing the previous day have gone OVER the total runs line.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Astros’ last eight home games against NL West opponents.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Giants’ last four games as favorites against AL West opponents.

San Francisco Giants vs Houston Astros Prediction

The Giants picked up the victory on Monday, but this game isn’t going to have the same result. Wesneski was solid for the Cubs last year. Don’t be fooled for the record; a lot of the times, he just didn’t get a ton of run support. In the first few games, the Astros’ pitching was good, and they are going to get back to those good graces here. Logan Webb isn’t going to be dominant here, and the Astros are going to end up finding success. Back the Astros to pick up the victory and to move above .500. 

Shane Mickle's Pick: Astros ML

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