Cleveland Guardians vs San Diego Padres Prediction 4/1/25 MLB Picks

San Diego Padres Betting Preview

The San Diego Padres are 5-0 on the year and play the Cubs, Athletics, and Rockies next. The San Diego Padres are batting .290 on the season, have a .358 OBP, and a .426 slugging percentage. The San Diego Padres' pitching staff has a 1.80 ERA and a 0.96 WHIP. Fernando Tatis Jr. leads the San Diego Padres with 9 hits and 3 RBI, while Gavin Sheets and Jackson Merrill have combined for 14 hits and 10 RBI.

Michael King gets the ball for the San Diego Padres, and he is 0-0 with a 10.13 ERA and 3 strikeouts this season. King is 1-0 with a 0.51 ERA and 24 strikeouts in his career against the Cleveland Guardians.

Why the San Diego Padres will win

• The Padres have won 12 of their last 13 home games.
• The Guardians have lost seven of their last eight games against NL West opponents that held a winning record.
• The Guardians have failed to cover the run line each of their last five road games against teams that held a winning record.
• The Padres have covered the run line in each of their last four home games against American League opponents after playing the previous day.
• The Guardians have trailed after 3 innings in each of their last three road night games.
• The Padres have led after 5 innings in six of their last eight games as favorites.

Why the Cleveland Guardians will win

• The Guardians have won each of their last six Tuesday night games as underdogs against National League opponents.
• The Padres have lost three of their last four Tuesday night games as favorites against American League opponents.
• The Guardians have covered the run line in 14 of their last 15 night games against National League opponents following a road loss.
• The Padres have failed to cover the run line in nine of their last 11 night games at Petco Park following a home win.

Cleveland Guardians vs San Diego Padres Prediction

The Cleveland Guardians haven’t been able to catch a break through four games, and Allen is coming off a rough season, to say the least. Allen has a 4.65 ERA and 1.48 WHIP through 222.2 career innings. The Padres are rolling through five games and they’re getting it done from the plate and the mound. The one time the Padres' starter didn’t perform was King, and he’s better than what he showed his first time out. The Padres are in too good of form at the moment to step in front of, especially when King has gotten the jitters out and should be better this time out. I’m rolling with the Padres and will lay the RL to shave down the juice.