Atlanta Braves vs San Diego Padres Prediction 3/29/25 MLB Picks

San Diego Padres Betting Preview

The San Diego Padres are off to a solid 2-0 start and have received contributions from their offense and pitching staff. Through two games, the Padres are hitting .313 and have three homers. The Padres' pitching staff has a 3.50 ERA, 1.22 WHIP, and 23 strikeouts in 18 innings. It’s still early, but this is what you expect from the Padres, who hope to finally crack the competitive NL West. Fernando Tatis Jr. leads the San Diego Padres with 4 hits and 1 RBI, while Jake Cronenworth and Jackson Merrill have combined for 6 hits and 5 RBI.

Randy Vasquez gets the ball for the Padres, and he was 4-7 with a 4.87 ERA and 62 strikeouts last season. Vasquez is 0-3 with a 4.40 ERA and 10 strikeouts in his career against the Braves.

Why the San Diego Padres will win

• The Padres have won five of their last six games as home underdogs against National League opponents.
• The Braves have lost each of their last five games against NL West opponents that held a winning record.
• The Padres have covered the run line in five of their last six games as underdogs against NL East opponents.
• The Braves have failed to cover the run line in four of their last five games as road favorites against NL West opponents.
• The Padres have led after 3 innings in five of their last six games against the Braves at Petco Park.
• The Braves have lost the first inning in four of their last five games at Petco Park.
• The Padres have led after 5 innings in three of their last four games at Petco Park against NL East opponents that held a losing record.

Why the Atlanta Braves will win

• The Braves have won each of their last eight Saturday games as favorites against NL West opponents.
• The Padres have failed to cover the run line in each of their last six games against National League opponents following a win.
• The Braves have covered the run line in eight of their last nine games against National League opponents following a road loss.
• The Padres have trailed after 5 innings in each of their last four day games against NL East opponents.

Atlanta Braves vs San Diego Padres Prediction

The Braves probably should be favored because Spencer Schwellenbach was more reliable than Randy Vasquez last season. The problem is that the Braves haven’t shown much at the plate through two games, and there are a lot of swings and misses. It’s hard to lay juice with a team averaging more than 10 strikeouts a game, small sample size or not. The Padres want to finally make a push in the NL West and build on last year's success, and they’re off to a strong start. The Padres have shown some scrappiness through two games. It’s hard to turn down the plus money with the Padres with the way things have played out through two games.