San Francisco Giants vs Cincinnati Reds Prediction 3/27/25 MLB Picks
Cincinnati Reds (0-0) vs San Francisco Giants (0-0)
Game Info: Thursday, March 27, 2025 at 4:10 pm (Great American Ball Park)
Logan Webb (R) vs Hunter Greene (R)
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Where to Watch: NBC Sports BA
The San Francisco Giants and the Cincinnati Reds meet on Thursday in MLB action from Great American Ballpark. We will look at this from a betting perspective and determine the best bets for this game. Here’s a San Francisco Giants vs. Cincinnati Reds prediction.
Starting Pitching Matchup
The San Francisco Giants will send out Logan Webb for the start here. Webb was 13-10 with a 3.47 ERA and 172 strikeouts last season. In his career, Webb is 2-2 with a 1.64 ERA and 30 strikeouts against Cincinnati. Hunter Greene will get the nod for the Reds here and was 9-5 with a 2.75 ERA and 169 strikeouts last season. In his career, Greene is 2-0 with a 0.00 ERA and 17 strikeouts against the Giants.
San Francisco Giants Team Preview
The San Francisco Giants come into the 2025 season looking to get out of the middling zone of .500 baseball after finishing with an 80-82 record, missing the playoffs for the third year in a row. Webb anchors the Giants’ rotation that now homes a pair of former Cy Young winners in Justin Verlander and the returning Robbie Ray, along with one of the most formidable bullpens in baseball. The infield should be interesting to watch as Willy Adames comes over in free agency, and Matt Chapman should be an interesting addition as well to go along with Jung Hoo Lee, who is hoping for a clean bill of health after a shoulder injury cut his season short last year. Only time will tell if the Giants can give the Dodgers a run for their money in the NL West or if it’s just another year of purgatory for San Francisco.
Why the San Francisco Giants will win
- The Reds have lost eight of their last nine day games after going to extra innings.
- The Giants have won five of their last six road games.
- The Reds have failed to cover the run line in 12 of their last 13 games against National League opponents following an extra innings win.
- The road team has covered the run line in eight of the Giants' last nine games.
San Francisco Giants Player Prop Facts
- Willy Adames has hit a home run in each of his last four road appearances against the Reds.
- Logan Webb has recorded a win in three of his last four road appearances against NL opponents.
- Willy Adames has recorded at least one RBI in seven of his last eight appearances against the Reds.
- Logan Webb has recorded six or more strikeouts in each of his last four appearances against the Reds.
- Willy Adames has scored at least one run in seven of his last eight appearances against the Reds.
- Jung Hoo Lee has recorded at least one Single in eight of his last nine appearances against NL opponents.
- Jung Hoo Lee has recorded at least one hit in each of his last nine appearances against NL opponents.
- Casey Schmitt has recorded a Double in three of his last four appearances in day games.
Cincinnati Reds Team Preview
The Cincinnati Reds will hope to take a step forward in 2025 after a disappointing 2024 campaign where the Reds finished 77-85 overall, their second losing season in the last three years, and missing the playoffs for the 4th consecutive season. The Reds have a new face leading the charge with Terry Francona taking over as bench boss, hopefully instilling a winning culture in Cincinnati. Brady Singer was acquired from the Royals to bolster the Reds’ rotation, led by Greene alongside Graham Ashcraft and Nick Lodolo, among others. The Reds still have one of the most exciting lineups in baseball, led by Elly De La Cruz, TJ Friedl, and Spencer Steer, just to name a few, and the addition of Jonathan India adds more depth to the Reds’ batting order. The addition of Tito and the makeup of this exciting Reds roster should give Cincy fans plenty of optimism heading into 2025.
Why the Cincinnati Reds will win
- The Giants have lost five of their last six season openers.
- The home team has won four of the Reds' last five games.
- The Giants have failed to cover the run line in each of their last six season openers.
- The Reds have covered the run line in 10 of their last 13 games against NL West opponents.
Cincinnati Reds Player Prop Facts
- Jose Trevino has scored a run in each of his three previous appearances in season openers.
- Santiago Espinal has recorded an RBI in five of his last six appearances against NL West opponents.
- Hunter Greene has recorded a win in four of his last five appearances against NL West opponents.
- Jake Fraley has recorded a Single in each of his last seven Thursday day appearances.
- Hunter Greene has recorded seven or more strikeouts in four of his last five home appearances.
- Santiago Espinal has recorded at least one hit in seven of his last eight appearances against NL West opponents.
- Tyler Stephenson has hit at least one home run in four of the Reds' last six games against NL West opponents.
Total Runs Facts
- Each of the Reds' last seven games have gone UNDER the total runs line.
- Eight of the Giants' last 10 day games against NL Central opponents have gone OVER the total runs line.
San Francisco Giants vs. Cincinnati Reds Prediction
I’m on Cincinnati in this one. I get the case to be made for the Giants, but the Great American Ballpark is an equalizer of a ballpark, and Logan Webb is a pitcher I trust far more in San Francisco than on the road. Hunter Greene, like a lot of Reds’ pitchers, was more effective on the road than at home last season but still allowed just a .209 opponents batting average at home, and I don’t love this Giants’ lineup on the road against right-handed pitching. I think the Reds start the season on a high note and get the job done here. Give me Cincinnati.
Chris’s Pick Cincinnati Reds
AUTHOR: Chris Ruffolo

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