Los Angeles Angels vs Milwaukee Brewers Prediction 9/17/2025 Today’s MLB Picks

The Los Angeles Angels and the Milwaukee Brewers meet Wednesday in MLB action from American Family Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Los Angeles Angels vs. Milwaukee Brewers prediction.

Starting Pitching Matchup

The Los Angeles Angels will start Jose Soriano for this one and Soriano is 10-10 with a 4.13 ERA and 152 strikeouts this season. This will be Soriano’s first career start against Milwaukee. Brandon Woodruff will get the nod for the Brewers here and is 6-2 with a 3.32 ERA and 74 strikeouts this season. This will be Woodruff’s second career start against the Angels.

Los Angeles Angels Recap

The Los Angeles Angels come into this game looking to bounce back from a 9-2 loss at the hands of the Brewers in Tuesday’s series opener to sit at 69-82 on the year. After this series, the Angels will head on the road for a series against the Colorado Rockies.

Angels Lose 5 In A Row

Logan O’Hoppe has 85 hits including 19 home runs and 43 RBIs while Nolan Schanuel has 123 hits with 22 doubles, a triple, 10 home runs and 49 RBIs. Luis Rengifo has 15 doubles with his 115 hits and Taylor Ward also has 120 hits as well while Mike Trout’s added 21 home runs and 58 RBIs so far this season. Jo Adell has 35 home runs and 94 RBIs. Ward has also chipped in 31 doubles, 30 home runs and 97 RBIs but has a team-high 158 strikeouts while Zach Neto has 29 doubles, 26 home runs, 62 RBIs and 26 stolen bases.

Milwaukee Brewers Recap

The Milwaukee Brewers will be out to add on to their victory over the Angels from Tuesday’s matchup to sit at 92-59 this season. After this series, the Brewers will head on the road for a division series rematch against the St. Louis Cardinals.

Brewers Win 6 Of Last 10

Brice Turang has 156 hits with 18 home runs, 75 RBIs and 24 stolen bases while Jackson Chourio has 139 hits with a team-high 33 doubles, 18 stolen bases, 20 home runs and 75 RBIs and Sal Frelick has 145 hits as well as 3 triples, 10 home runs, 57 RBIs and 19 stolen bases so far this season. Christian Yelich also has 16 stolen bases with 28 homers and 96 RBIs while also adding 18 doubles. Yelich also has a team-high 157 strikeouts up to this point in the year. William Contreras has 17 homers and 74 RBIs as well this season. Joey Ortiz has chipped in 100 hits with 17 doubles, 7 home runs and 44 RBIs and Caleb Durbin also has 24 doubles with 11 homers and 49 RBIs. 

Los Angeles Angels @ Milwaukee Brewers Betting Trends: September 17, 2025

• Probable Starting Pitcher: Brandon Woodruff      Record this season: 6-2      ERA: 3.32
• Home Record: 2-0
• Last 5 against Angels: 0-1

Why the Milwaukee Brewers will win

• The home team has won each of the Angels’ last seven games.
• The Angels have lost each of their last six road games.
• The Angels have failed to cover the run line in each of their last seven night games against NL Central opponents following a loss.
• The Brewers have covered the run line in seven of their last eight night games against AL West opponents that held a losing record.
• The Angels have trailed after 5 innings in each of their last seven games as underdogs against National League opponents.
• The Brewers have led after 3 innings in each of their last six games as home favorites against AL West opponents.
• The Angels have lost the first inning in each of their last three games.

• Probable Starting Pitcher: Jose Soriano      Record this season: 10-10      ERA: 4.13
• Road Record: 8-2
• Last 5 against Brewers: –

Why the Los Angeles Angels will win

• The Brewers have lost five of their last six games as home favorites after playing the previous day.
• The Angels have won 12 of their last 17 games as road underdogs against National League opponents following a loss.
• The Brewers have failed to cover the run line in each of their last seven home games following a win.
• The underdogs have covered the run line in eight of the Brewers’ last 10 games at American Family Field.
• The Brewers have trailed after 5 innings in five of their last six games as favorites against American League opponents.

Total Runs Facts

• Each of the Angels’ last four road games against NL Central opponents have gone OVER the total runs line.
• Five of the Brewers’ last six games have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in nine of the Angels’ last 10 games as underdogs against National League opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in nine of the Brewers’ last 10 night games against American League opponents.

Milwaukee Brewers Player Prop Facts

• Sal Frelick has recorded a Double in four of his last five appearances in night games against AL West teams that held a losing record.
• Brandon Woodruff has recorded six or more strikeouts in nine of his last 10 appearances against opponents that held a losing record.
• Christian Yelich has hit a home run in each of the Brewers’ last two night games against AL opponents that held a losing record.
• Brandon Woodruff has recorded a win in each of his last six appearances in night games against teams that held a losing record.
• Sal Frelick has recorded at least one hit in each of his last 11 appearances with the Brewers as home favorites against AL opponents.

Los Angeles Angels Player Prop Facts

• Jo Adell has hit a home run in three of his last four appearances after playing the previous day.
• Nolan Schanuel has recorded two or more hits in each of his last three appearances with the Angels as road underdogs.

Los Angeles Angels vs. Milwaukee Brewers Prediction

I’m on the Brewers in this one. I get the case to be made for an underdog in some spots and Jose Soriano’s been a lot better on the road this season. However, Soriano’s struggled as of late and the Brewers are back on their game and looked really strong in Tuesday’s opener. I think the Brewers add another win here so give me Milwaukee in this one.