Sep 5, 2026; Durham, North Carolina, USA;  Duke Blue Devils running back Nate Sheppard (20) reacts after scoring against the Tulane Green Wave during the first quarter at Wallace Wade Stadium.  Mandatory Credit: Zachary Taft-Imagn Images
IMAGN IMAGES via Reuters Connect

Stanford vs Duke Prediction 9/19/2026 Today’s College Football Picks

Pick details

MATCHUP Stanford Cardinal Duke Blue Devils
Team Records 1-1 2-0
Spread +10 -110 -10 -110
Moneyline +320 -410
Total Over 50.5 (-115) Under 50.5 (-105)
Where Wallace Wade Stadium, Durham, NC
When Saturday, September 19, 2026
Time 04:00 PM EDT
TV CW

The Stanford Cardinal and Duke Blue Devils meet Saturday in week 3 college football action at Wallace Wade Stadium. Here’s a Stanford vs. Duke Prediction. This article will include a Stanford vs. Duke Pick.

Stanford Cardinal Betting Preview


The Stanford Cardinal beat Hawaii, lost to Miami, and they play Georgia Tech next. Stanford has lost 5 of its last 7 games. Davis Warren is completing 57.3 percent of his passes for 524 yards, 1 touchdown, and 0 interceptions. Benji Blackburn and Caden High have combined for 193 receiving yards on 18 catches, while JonAnthony Hall has 3 receptions.

The Stanford Cardinal ground game is averaging 118 yards per contest, and Micah Ford leads the way with 126 yards and 3 touchdowns. On defense, Stanford allows 36 points and 437 yards per game. Matt Rose leads the Stanford Cardinal with 21 tackles, Gabe Kaminski has 1.5 sacks, and Charlie Eckhardt has 1 interception.

Duke Blue Devils Betting Preview


The Duke Blue Devils beat Tulane and Illinois, and they play William & Mary next. Duke has won 6 straight games. Walker Eget is completing 59.6 percent of his passes for 337 yards, 3 touchdowns, and 0 interceptions. Jonah Burton and Jeremiah Hasley have combined for 203 receiving yards and 1 touchdown, while Nate Sheppard has 8 receptions.

The Duke Blue Devils ground game is averaging 210 yards per contest, and Nate Sheppard leads the way with 374 yards and 3 touchdowns. Defensively, Duke is allowing 15 points and 320 yards per game. Nick Morris Jr. leads the Duke Blue Devils with 15 tackles, Bradley Gompers has 1 sack, and Evan Smith has 1 interception.

Why the Duke Blue Devils will win

  • Duke has won each of its last 11 September home games against non-AP-ranked teams.
  • Stanford has lost each of its last eight road games against non-AP-ranked teams.
  • Duke has covered the spread in each of its last four September games as a favorite.
  • Stanford has failed to cover the spread in six of its last seven games as a road underdog.
  • Stanford has lost the first half in five of its last six games in September.

Why the Stanford Cardinal will win

  • Stanford has covered the spread in four of its last five games against non-AP-ranked teams.

Total Points Facts

  • Five of Duke’s last six games as a favorite against non-AP-ranked teams have gone OVER the total points line.
  • Four of Stanford’s last five road games against non-AP-ranked teams have gone UNDER the total points line.

Duke Blue Devils Player Prop Facts

  • Nate Sheppard has recorded 75+ rushing yards in six consecutive games- the longest streak in the FBS, heading into Week 3.

Stanford Cardinal Player Prop Facts

  • Heading into Week 3, Micah Ford ranks T11th amongst FBS players for rushing touchdowns (3) this season.

Matchup/League Facts

  • Duke ranks T26th among FBS teams for Q3 opponent points per game this season (1.5).
  • Duke ranks T113th among FBS teams for passing yards per game this season (168.5).
  • Stanford ranks T126th among FBS teams for Q4 opponent points per game this season (11.5).
  • Stanford ranks T126th among FBS teams for H2 opponent points per game this season (18.5).

Stanford vs Duke Prediction


Stanford just hasn’t been impressive through two games, as it got taken behind the woodshed against Miami and should have lost to Hawaii. Stanford is limited offensively and looks awful defensively. Duke is not only winning games dating back to last season, but it’s covered 5 of its last 6 games. Duke is quietly becoming a decent betting option on the football side. Imagine that. Anyways, I want little to do with Stanford. Give me Duke in a comfortable home victory.

Randy Chambers's Pick: Duke -10

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