Oklahoma State vs West Virginia Prediction 9/26/2026 Today’s College Football Picks

The Oklahoma State Cowboys and the West Virginia Mountaineers meet in week 4 college football action from Milan Puskar Stadium on Saturday. We will look at this from a betting perspective and determine the best bets for this game. Here’s an Oklahoma State Cowboys vs. West Virginia Mountaineers Prediction.

Oklahoma State Cowboys Recap

The Oklahoma State Cowboys come into this game looking to add on to their 59-0 win over Murray State last time out to improve to 2-1 on the year. After this game, Oklahoma State will head home for a matchup against UCF.

Cowboys Win Back-To-Back Games

Drew Mestemaker has thrown for 882 yards, 8 touchdowns and 4 interceptions on 65.8% passing while Caleb Hawkins leads Oklahoma State in rushing with 261 rushing yards and 1 touchdown so far this season. Ayo Adeyi sits behind Hawkins on the ground with 115 yards and 0 TDs. Justin Bowick leads the Cowboys in receiving with 281 yards on 16 catches along with 3 touchdowns, while Wyatt Young trails with 218 yards on 14 catches along with 2 touchdowns. On defense, Ethan Wesloski has a team-high 19 total tackles, Jaleel Johnson, Keviyan Huddleston, and Enai White each lead the team with 1 sack, and LaDainian Fields and Enai White have each recorded 1 interception. Oklahoma State’s defense as a whole has combined for 4 sacks and 2 interceptions so far this season.

West Virginia Mountaineers Recap

The West Virginia Mountaineers come into this game looking to build on their 38-27 win over Virginia last time out to sit at 3-0 on the year. After this game, West Virginia will head on the road for a game against Iowa State.

Mountaineers Looking To Stay Unbeaten

Michael Hawkins Jr. has thrown for 477 yards, 5 touchdowns and 0 interceptions on 68.4% passing while also leading West Virginia in rushing with 322 rushing yards and 6 touchdowns so far this season. Cam Cook sits behind Hawkins Jr. on the ground with 317 yards and 3 TDs. DJ Epps leads the Mountaineers in receiving with 240 yards on 8 catches along with 3 touchdowns, while Jaden Bray trails with 96 yards on 6 catches. On defense, Isaiah Patterson has a team-high 26 total tackles, Ashton Woods leads the unit with 2 sacks, and Woods also recorded the team’s lone interception. West Virginia’s defense as a whole has combined for 10 sacks and 1 interception so far this season.

Oklahoma State Cowboys @ West Virginia Mountaineers Betting Trends: Week 4

Why the West Virginia Mountaineers will win

• Oklahoma State has lost each of its last 19 games against conference opponents.
• West Virginia has won 22 of its last 24 September games at Milan Puskar Stadium.
• The home team has covered the spread in each of Oklahoma State’s last four games.
• Oklahoma State has failed to cover the spread in four of its last five road games in September.
• West Virginia has won the first half in 13 of its last 14 home games in September.
• West Virginia has won the first quarter in each of its last four games against non-AP-ranked teams.

Why the Oklahoma State Cowboys will win

• Oklahoma State has won each of its last four games as an underdog against West Virginia.
• West Virginia has lost eight of its last nine home games against teams from Oklahoma.
• West Virginia has failed to cover the spread in eight of its last nine home games against teams from Oklahoma.
• Oklahoma State has covered the spread in each of its last five road games against West Virginia.
• West Virginia has lost the first half in eight of its last 10 games against conference opponents.
• The underdog has won the first quarter in each of the last four games between Oklahoma State and West Virginia.

Total Points Facts

• Nine of West Virginia’s last 10 September games as a home favorite against non-AP-ranked teams have gone OVER the total points line.
• Each of Oklahoma State’s last five games against non-AP-ranked teams have gone UNDER the total points line.

West Virginia Mountaineers Player Prop Facts

• Cam Cook has recorded 50+ rushing yards in 16 consecutive games – longest streak in the FBS, heading into Week 4.

Oklahoma State Cowboys Player Prop Facts

• Heading into Week 4, Sam Keltner ranks T10th amongst FBS players for made field goals (6) this season.

Matchup/League Facts

• West Virginia ranks T1st among FBS teams for Q2 opponent points per game this season (0.0).
• West Virginia ranks T1st among FBS teams for 4th down conversion percentage this season (100.0).
• Oklahoma State ranks 3rd among FBS teams for red zone percentage against this season (50.0).
• Oklahoma State ranks T4th among FBS teams for 1st downs this season (85).

Oklahoma State Cowboys vs. West Virginia Mountaineers Prediction

I’m on the Mountaineers in this one. I get the case to be made for Oklahoma State, but I’m just not sure what the Cowboys are if I’m being honest. I mean Oklahoma State has a win over Oregon as massive dogs, a loss as big favorites to Tulsa and a blowout win over Murray State. I feel like I’ve been left with a more impressive feeling with WV at this point, and Hawkins looks reborn under Rich Rod’s offense. I think West Virginia defends home soil here with a win and cover so give me West Virginia.

Chris Ruffolo's Pick: West Virginia -1.5