Oct 10, 2026; Stillwater, Oklahoma, USA;  Oklahoma State Cowboys wide receiver Chris Barnes (2) runs the ball after a reception during the second half against the UCF Knights at Boone Pickens Stadium.  Mandatory Credit: William Purnell-Imagn Images
IMAGN IMAGES via Reuters Connect

Oklahoma State vs Houston Prediction 10/17/2026 Today’s College Football Picks

Pick details

MATCHUP Oklahoma State Cowboys Houston Cougars
Team Records 4-1 5-1
Spread +4.5 -110 -4.5 -110
Moneyline +160 -192
Total Over 62.5 (-110) Under 62.5 (-110)
Where TDECU Stadium, Houston, TX
When Saturday, October 17, 2026
Time 07:30 PM EDT
TV Fox

The Oklahoma State Cowboys and the Houston Cougars meet in week 7 college football action from 
TDECU Stadium on Saturday. We will look at this from a betting perspective and determine the best bets for this game. Here’s an Oklahoma State Cowboys vs. Houston Cougars Prediction.

Oklahoma State Cowboys Recap

The Oklahoma State Cowboys come into this game looking to add on to their 42-28 win over UCF last time out to sit at 4-1 this season. After this game, Oklahoma State will head home for a game against Colorado.

Cowboys Win 4 Straight

Drew Mestemaker has thrown for 1,575 yards, 13 touchdowns and 5 interceptions on 67.5% passing while Caleb Hawkins leads Oklahoma State in rushing with 524 yards and 2 touchdowns. Ayo Adeyi sits behind Hawkins on the ground with 180 yards. Wyatt Young leads the Cowboys in receiving with 462 yards and 27 catches along with 4 touchdowns, while Justin Bowick trails with 442 yards and 26 catches along with 5 touchdowns. On defense, Ethan Wesloski has a team-high 53 tackles while Oklahoma State’s defense as a whole has combined for 4 sacks and 5 interceptions.

Houston Cougars Recap

The Houston Cougars come into this game looking to add on to their 35-16 win over Kansas State last time out to sit at 5-1 this season. After this game, Houston will head on the road for a game against Utah.

Cougars Win 3 In A Row

Conner Weigman has thrown for 1,428 yards, 15 touchdowns and an interception on 66.7% passing while Re’Shaun Sanford II leads Houston in rushing with 404 yards and 2 touchdowns. Makhi Hughes sits behind Sanford II on the ground with 387 yards and 3 touchdowns. Patrick Overmyer leads the Cougars in receiving with 400 yards and 33 catches along with 6 touchdowns, while Amare Thomas trails with 361 yards and 29 catches along with 4 touchdowns. On defense, Kentrell Webb has a team-high 38 tackles while Houston’s defense as a whole has combined for 12 sacks and 5 interceptions.

Oklahoma State Cowboys @ Houston Cougars Betting Trends: Week 7

 

Why the Houston Cougars will win

  • Houston has won each of its last 13 October games as a favorite.
  • Oklahoma State has lost each of its last six games against teams from Texas.
  • Oklahoma State has failed to cover the spread in each of its last five October games as an underdog.
  • The home team has covered the spread in five of Oklahoma State’s last six games.
  • Houston has won the first quarter in five of its last six games.
  • Oklahoma State has lost the first half in eight of its last nine road games.

Why the Oklahoma State Cowboys will win

  • Oklahoma State has won each of its last four games.
  • Houston has lost 17 of its last 20 games against AP-ranked teams.
  • Oklahoma State has covered the spread in each of its last six games as an underdog.
  • Houston has failed to cover the spread in each of its last four home games against teams from Oklahoma.
  • The underdog has won the first quarter in three of Houston’s last four games.
  • The road team has won the first half in each of Houston’s last four games.

Total Points Facts

  • Nine of Houston’s last 10 games as a favorite have gone OVER the total points line.
  • Eight of Oklahoma State’s last 10 games as an underdog against teams from Texas have gone OVER the total points line.

Houston Cougars Player Prop Facts

  • Heading into Week 7, Conner Weigman ranks 2nd in the league for TD:INT ratio (15.00) this season.

Oklahoma State Cowboys Player Prop Facts

  • Heading into Week 7, Sam Keltner ranks T3rd amongst FBS players for made field goals (12) this season.

Matchup/League Facts

  • Houston ranks 1st among FBS teams for 3rd down conversion percentage this season (62.7).
  • Houston ranks T3rd among FBS teams for 1st downs this season (162).
  • Oklahoma State ranks 6th among FBS teams for yards per game this season (521.4).
  • Oklahoma State ranks 6th among FBS teams for passing yards per game this season (322.4).

Oklahoma State Cowboys vs. Houston Cougars Prediction

I’m on Houston in this one. This will be a great matchup between two teams realy looking to put their stamp on the Big 12 this season, but I think I’m left more impressed with Houston from an all-around perspective, rather than OK State who just looks like they can flat out outscore teams but leave a bit to be desired when it comes to their defense. I think Houston delivers in a big statement spot at home so give me Houston.

Chris Ruffolo's Pick: Houston -4.5

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