Notre Dame vs Purdue Prediction 9/26/2026 Today’s College Football Picks

The Notre Dame Fighting Irish and Purdue Boilermakers meet Saturday in week 4 college football action at Ross-Ade Stadium. Here’s a Notre Dame vs. Purdue Prediction. This article will include a Notre Dame vs. Purdue Pick.

Notre Dame Fighting Irish Betting Preview

The Notre Dame Fighting Irish beat Michigan State and Rice, and play North Carolina next. The Notre Dame Fighting Irish have won 13 straight games. CJ Carr is completing 72.6 percent of his passes for 726 yards, 6 touchdowns, and 0 interceptions. Jordan Faison and Micah Gilbert have combined for 424 receiving yards and 3 touchdowns, while Nolan James Jr. has 7 receptions.

The Notre Dame Fighting Irish ground game is averaging 130 yards per contest, and Nolan James Jr. leads the way with 169 yards and 3 touchdowns. Defensively, Notre Dame is allowing 7.7 points and 193 yards per game. Drayk Bowen leads the Notre Dame Fighting Irish with 19 tackles, Boubacar Traore has 2 sacks, and DJ McKinney has 1 interception.

Purdue Boilermakers Betting Preview

The Purdue Boilermakers lost to Wake Forest and UCLA, and they play Illinois next. The Purdue Boilermakers have lost 12 of their last 14 games. Ryan Browne is completing 73.3 percent of his passes for 1,024 yards, 7 touchdowns, and 1 interception. Asaad Waseem and Xavier Townsend have combined for 588 receiving yards and 3 touchdowns, while Chauncey Magwood has 8 receptions.

The Purdue Boilermakers’ ground game is averaging 183 yards per contest, and Fame Ijeboi leads the way with 248 yards and 6 touchdowns. Defensively, Purdue is allowing 54.5 points and 670 yards per game. John Slaughter leads the Purdue Boilermakers with 22 tackles, Ian Jeffries has 1 sack, and Don Saunders has 1 interception.

Why the Purdue Boilermakers will win

• Purdue has won three of its last four home games against non-conference opponents.

Why the Notre Dame Fighting Irish will win

• Notre Dame has won each of its last 13 games.
• Purdue has lost each of its last 10 games against top-15 AP-ranked teams.
• Notre Dame has covered the spread in each of its last four games as a favorite against teams from Indiana.
• Purdue has failed to cover the spread in six of its last seven games against AP-ranked teams at Ross-Ade Stadium.
• Notre Dame has won the first half in each of its last 13 games as a favorite.

Total Points Facts

• Nine of Notre Dame’s last 10 September games as a road favorite against non-AP-ranked teams have gone OVER the total points line.
• Each of Purdue’s last five games as a home underdog against teams from Indiana have gone OVER the total points line.

Purdue Boilermakers Player Prop Facts

• Ryan Browne has recorded 275+ passing yards in three consecutive games- the longest streak in the FBS, heading into Week 4.

Notre Dame Fighting Irish Player Prop Facts

• Heading into Week 4, CJ Carr ranks 14th amongst qualified players for passer rating (183.3) this season.

Matchup/League Facts

• Purdue is one of 10 FBS teams to score in every quarter this season.
• Purdue ranks 128th among FBS teams for points allowed per game this season (36.3).
• Notre Dame has won the first quarter in each of its last seven games- the longest active streak in the FBS.
• Notre Dame has won the third quarter in each of its last 14 games – longest active streak in the FBS.

Notre Dame vs Purdue Prediction

Notre Dame has the ability to blow the doors off, but this is a ton of points for a road spot. Also, Purdue deserves some credit as it nearly beat Wake Forest and then went into UCLA and dropped 38 points. Now Purdue hasn’t played a lot of defense, but the fight has improved, and there are sparks of successful offense. Purdue is already a better team than it’s been in past seasons. If the trend upward continues, the Boilermakers can cash our ticket. Give me the four free touchdowns.

Randy Chambers's Pick: Purdue +27.5