Northwestern vs Indiana Prediction 9/25/2026 Today’s College Football Picks

The Northwestern Wildcats and Indiana Hoosiers meet Friday in week 4 college football action at Memorial Stadium. Here’s a Northwestern vs. Indiana Prediction. This article will include a Northwestern vs Indiana Pick.

Northwestern Wildcats Betting Preview

The Northwestern Wildcats beat South Dakota State and Colorado, and they play Penn State next. The Northwestern Wildcats look for their first 3-0 start since the 2020 season. Aidan Chiles is completing 67.4 percent of his passes for 514 yards, 4 touchdowns, and 0 interceptions. Griffin Wilde and Luke Dehnicke have combined for 257 receiving yards on 12 catches, while Caleb Komolafe has 5 receptions.

The Northwestern Wildcats’ ground game is averaging 203 yards per contest, and Gavin Sawchuk leads the way with 117 yards on 20 carries. Defensively, Northwestern is allowing 12.5 points and 390 yards per game. Robert Fitzgerald leads the Northwestern Wildcats with 25 tackles, Kobie McKinzie has 1 sack, and Damon Walters has 1 interception.

Indiana Hoosiers Betting Preview

The Indiana Hoosiers beat Howard and Western Kentucky, and they play Rutgers next. Indiana has won 19 straight games. Josh Hoover is completing 72.5 percent of his passes for 649 yards, 10 touchdowns, and 0 interceptions. Charlie Becker and Nick Marsh have combined for 441 receiving yards and 8 touchdowns, while Shazz Preston has 5 receptions.

The Indiana Hoosiers’ ground game is averaging 221 yards per contest, and Turbo Richard leads the way with 315 yards and 4 touchdowns. Defensively, Indiana is allowing 5.3 points and 203.3 yards per game. Isaiah Jones leads the Indiana Hoosiers with 22 tackles, Keishaun Calhoun has 2 sacks, and Rolijah Hardy has 1 interception.

Why the Indiana Hoosiers will win

• Indiana has won each of its last 19 games.
• Northwestern has lost 19 of its last 20 games against AP-ranked teams.
• Indiana has covered the spread in each of its last six games as a favorite against teams from Illinois.
• Northwestern has failed to cover the spread in six of its last seven road openers.
• Northwestern has lost the first half in 12 of its last 13 games as an underdog.

Why the Northwestern Wildcats will win

• Northwestern has won four of its last five games in September.
• Indiana has failed to cover the spread in each of its last four games at Memorial Stadium (Bloomington).
• Northwestern has covered the spread in each of its last four games against top-5 AP-ranked teams.

Total Points Facts

• Seven of Northwestern’s last eight games as an underdog against top-15 AP-ranked teams have gone UNDER the total points line.
• Eleven of Indiana’s last 13 September games as a home favorite have gone OVER the total points line.

Indiana Hoosiers Player Prop Facts

• Heading into Week 4, Josh Hoover ranks 2nd amongst qualified players for passer rating (244.1) this season.

Northwestern Wildcats Player Prop Facts

• Heading into Week 4, Aidan Chiles ranks 9th amongst qualified players for passer rating (189.9) this season.

Matchup/League Facts

• Indiana has recorded the equal-most home wins by a margin of 20+ points of any FBS team this season (3).
• Indiana has recorded the equal-most home wins by a margin of 25+ points of any FBS team this season (3).
• Northwestern ranks T1st among FBS teams for red zone percentage this season (100.0).
• Northwestern ranks T3rd among FBS teams for H1 opponent points per game this season (3.0).

Northwestern vs Indiana Prediction

Indiana obviously can blow the doors off, but it’s also 0-4 ATS in its last four games. Northwestern is usually an afterthought in the Big Ten and never has talented difference makers, but that didn’t stop the Wildcats from smoking Colorado. Northwestern also made light work of Central Michigan. Up to this point, Northwestern has a balanced offense and a bend-but-don’t-break defense. Northwestern is 105th in total defense but 20th in scoring defense. We’re getting three touchdowns. I’ll grab the points with Northwestern.

Randy Chambers's Pick: Northwestern +20.5