Sep 19, 2026; University Park, Pennsylvania, USA;  Buffalo Bulls running back James McNeil Jr. (24) reacts after scoring a touchdown during the fourth quarter against the Penn State Nittany Lions at West Shore Home Field at Beaver Stadium.  Mandatory Credit: Matthew O'Haren-Imagn Images
IMAGN IMAGES via Reuters Connect

Buffalo vs Toledo Prediction 10/10/2026 Today’s College Football Picks

Pick details

MATCHUP Buffalo Bulls Toledo Rockets
Team Records 2-3 4-1
Spread +20.5 -105 -20.5 -115
Moneyline +900 -1600
Total Over 55.5 (-110) Under 55.5 (-110)
Where Glass Bowl, Toledo, OH
When Saturday, October 10, 2026
Time 03:30 PM EDT
TV ESPN+

In this article we will formulate a Buffalo vs Toledo prediction for this College Football game on Saturday, October 10th at the Glass Bowl in Toledo, Ohio. Let’s take a look at the prediction for this Week 6 matchup. 

Buffalo Bulls Betting Preview

The Buffalo Bulls are 2-3 (0-1) this season after they lost to Western Michigan by a score of 20-17 last week. Buffalo led 14-10 at halftime and 17-10 in the fourth, but they allowed the last 10 points and got stuffed inside the five to end the game. The Bulls were out gained by a total of 327-305, went 5-14 on third downs, and tied the turnover battle at zero in the game. Jason Wright threw for 170 yards and one touchdown, while Chance Morrow caught seven passes for 90 yards. Messiah Burch rushed 23 times for 106 yards and one score in the loss. 

Prior to that game, Buffalo defeated Robert Morris by a score of 31-28, but lost to Penn State by a score of 55-13 before that. The Bulls have scored 20.4 points per game with 161.0 passing yards and 151.4 rushing yards per game, while they have allowed 30.6 points against per game this season. Jason Wright has thrown for 555 yards with four touchdowns and three interceptions this season. 

Toledo Rockets Betting Preview

The Toledo Rockets are 4-1 (1-0) this year after they defeated Ball State by a score of 39-24 in their last game. Toledo led 15-10 at halftime and they scored 24 points in the second half to secure the win. The Rockets out gained Ball State by a total of 553-370, went 8-18 on third downs, and won the turnover battle by a total of 2-0 in the game. John Alan Richter threw for 201 yards and one touchdown, while Adjatay Dabbs caught six passes for 82 yards. CJ Miller rushed 20 times for 196 yards and two touchdowns in the win. 

Prior to that game, Toledo defeated San Diego State by a score of 41-16 and Temple by a score of 49-48. The Rockets have scored 42.4 points per game with 284.6 passing yards and 200.4 rushing yards per game, while they have allowed 25.6 points against per game this season. John Alan Richter has thrown for 1,362 yards with 13 touchdowns and one interception this year. 

Why the Toledo Rockets will win

  • Toledo has won each of its last nine games against non-AP-ranked teams at Glass Bowl.
  • Buffalo has lost each of its last six games as an underdog.
  • Buffalo has failed to cover the spread in seven of its last eight October games as a road underdog against non-AP-ranked teams.
  • Toledo has covered the spread in six of its last seven home games in October.
  • Toledo has won the first half in each of its last six games against conference opponents at Glass Bowl.

Why the Buffalo Bulls will win

  • Buffalo has won three of its last four October games as an underdog against Toledo.
  • Toledo has lost four of its last six October games as a favorite against non-AP-ranked teams.
  • Toledo has failed to cover the spread in five of its last six October games as a favorite.
  • Buffalo has covered the spread in three of its last four games as an underdog against Toledo.

Total Points Facts

  • Each of Toledo’s last six home games have gone OVER the total points line.
  • Five of Buffalo’s last six road games have gone OVER the total points line.

Toledo Rockets Player Prop Facts

  • Heading into Week 6, John Alan Richter ranks 3rd amongst qualified players for sack percentage (1.3%) this season.

Buffalo Bulls Player Prop Facts

  • Heading into Week 6, Chance Morrow ranks 1st in the Mid-American Conference for receiving yards (397) this season.

Matchup/League Facts

  • Toledo ranks T7th among FBS teams for Q4 points per game this season (11.6).
  • Toledo ranks T131st among FBS teams for sacks this season (2.0).
  • Buffalo ranks 138th among FBS teams for average point differential in first quarters this season (-7.8).
  • Buffalo ranks T132nd among FBS teams for Q1 opponent points per game this season (10.4).

Buffalo vs Toledo Prediction

Toledo rolls into this matchup on a four game winning streak and they have scored 39+ points in all four wins. The Rockets have an elite quarterback and they are putting up a ton of passing yards. Buffalo has yet to win a FBS game, but they did play Western Michigan pretty tough last week. The Bulls have allowed 33+ in two of their last three FBS games and I don’t see them getting many stops here. On the other side, the Toledo defense is very average, so we should see some scoring from Buffalo. Take the over here.

David Racey's Pick: Over 55.5

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