Wake Forest vs Memphis Prediction 11/21/2025 Today’s College Basketball Picks

The Wake Forest Demon Deacons and the Memphis Tigers meet Friday in college basketball action from the Baha Mar Convention Center. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Wake Forest Demon Deacons vs. Memphis Tigers prediction.

Wake Forest Demon Deacons Recap

The Wake Forest Demon Deacons come into this game looking to bounce back from a narrow 84-83 loss to Texas Tech in their last game to sit at 3-2 this season.

Demon Deacons Looking To Bounce Back From Heartbreaker

Going into Thursday’s game against Texas Tech, Juke Harris leads the Demon Deacons in scoring and rebounding with 21.8 PPG and 7 RPG while Tre’Von Spillers has 16.3 PPG with 6.5 RPG and 2 APG and Mekhi Mason has 12.5 PPG with 5.5 RPG and 2.5 APG to cap off the group of double-digit scorers for Wake Forest up to this point in the year. Myles Colvin has 9.5 PPG with 3.8 RPG and Nate Calmese has 9.5 PPG with 3.8 RPG and team-highs of 6 APG and 2.5 SPG to lead the Demon Deacons in assists and steals. As a team, Wake Forest is averaging 90.5 PPG on 43.9% shooting from the field, 32.7% from three and 73.7% from the foul line this season.

Memphis Tigers Recap

The Memphis Tigers will attempt to bounce back from an 80-71 loss to Purdue in their last game to sit at 1-3 this season. 

Tigers Drop 3 In A Row

Entering Thursday’s matchup with Purdue, Sincere Parker leads the Tigers in scoring with 11.3 PPG and 3.7 RPG while Curtis Givens III has 10.7 PPG with 2.3 SPG and Dug McDaniel has 10.7 PPG with 3 RPG and a team-high 5.7 APG to lead the Tigers in assists and to cap off the trio of double-digit scorers for Memphis up to this point in the year. Ashton Hardaway has 9.7 PPG while Quante Berry has 9.3 PPG with 3 RPG and Julius Thedford has 7.7 PPG with 5.7 RPG as well on the year. As a team, Memphis is averaging 77 PPG on 42.7% shooting from the field, 32.3% from three and 68.4% from the foul line this season. 

Wake Forest Demon Deacons @ Memphis Tigers Betting Trends: November 21, 2025

Why the Memphis Tigers will win

• Memphis has won each of its last six games against the Atlantic Coast Conference.
• Wake Forest has lost four of its last five games played at neutral venues.
• Wake Forest has lost the first half in each of its last seven games played at neutral venues.

Why the Wake Forest Demon Deacons will win

• Wake Forest has won each of its last eight Friday games played at neutral venues.
• Memphis has lost four of its last five games.
• Memphis has lost the first half in each of its last five night games against non-Conference opponents.

Matchup/League Facts

• Wake Forest ranks T11th among Division 1 teams for field goal attempts per game this season (70.6).
• Wake Forest ranks T23rd among Division 1 teams for steals per game this season (11.0).

Wake Forest Demon Deacons vs. Memphis Tigers Prediction

I’m on Wake Forest here. It’s a bit of a tricky spot considering both of these teams left everything they had on the floor against their tougher competition on Thursday, but I left more impressed with Wake Forest than I did Memphis. Sure, Memphis went toe-to-toe with Purdue and the Boilermakers never got a sniff of the cover, but Memphis had a lead and then missed a lot of shots and let Purdue overtake them and not look back. Wake Forest seemed live for the upset the entire game against Texas Tech and led for a lot of it and I think they follow through and get the win here. Give me Wake Forest.

Chris Ruffolo's Pick: Wake Forest -2.5