Nov 14, 2025; Inglewood, California, USA; Southern California Trojans guard Rodney Rice (1) shoots a free throw during the first half of the Hall of Fame Series game against the Illinois State Redbirds at Intuit Dome. Mandatory Credit: Kiyoshi Mio-Imagn Images
Kiyoshi Mio-Imagn Images

Oregon vs USC Prediction 2/21/2026 Today’s College Basketball Picks

Pick details

MATCHUP Oregon Ducks USC Trojans
Team Records 9-17 18-8
Spread +5.5 -115 -5.5 -105
Moneyline +200 -245
Total Over 149.5 (-112) Under 149.5 (-108)
Where Galen Center, Los Angeles, CA
When Saturday, February 21, 2026
Time 04:00 PM EST
TV FS1

The Oregon Ducks and USC Trojans meet Saturday in college basketball action at the Galen Center. Here’s a Oregon vs USC Prediction. This article will include a Oregon vs USC Pick.

Oregon Ducks Betting Preview

The Oregon Ducks lost to Minnesota, beat Penn State, and they play Wisconsin next. Oregon has lost 10 of its last 11 games.

The Oregon Ducks are averaging 71.2 points on 42.5 percent shooting and allowing 74.4 points on 44.7 percent shooting. Nate Bittle is averaging 16.8 points and 6.7 rebounds, while Jackson Shelstad is averaging 15.6 points and 2.9 rebounds. Kwame Evans Jr. is the third double-digit scorer and Takai Simpkins is grabbing 2.9 rebounds. The Oregon Ducks are shooting 32.2 percent from beyond the arc and 71.9 percent from the free throw line. The Oregon Ducks are allowing 34.4 percent shooting from deep and are grabbing 31.6 rebounds per game.

USC Trojans Betting Preview

The USC Trojans lost to Ohio State and Illinois, and they play UCLA next. USC has split its last 10 games.

The USC Trojans are averaging 80.7 points on 46.5 percent shooting and allowing 76.8 points on 42.5 percent shooting. Rodney Rice is averaging 20.3 points and 6 assists, while Chad Baker-Mazara is averaging 18.3 points and 3 assists. Ezra Ausar is the third double-digit scorer and Alijah Arenas is grabbing 2.6 rebounds. The USC Trojans are shooting 32.3 percent from beyond the arc and 71.6 percent from the free throw line. The USC Trojans are allowing 31.1 percent shooting from deep and are grabbing 33.5 rebounds per game.

Why the USC Trojans will win

  • Oregon has lost 11 of its last 12 games against Conference opponents.
  • USC has won each of its last five day games against non-AP-ranked opponents.
  • Oregon has lost the first half in seven of its last eight games against Conference opponents.

Why the Oregon Ducks will win

  • Oregon has won each of its last three road games against USC.
  • USC has lost three of its last four day games against the Big Ten Conference at Galen Center.
  • USC has lost the first half in three of its last four day games against Conference opponents.

Total Points Facts

  • Each of USC’s last five games against Conference opponents have produced a total of 152+ points.
  • Five of Oregon’s last six games at Galen Center have produced a total of 147 or fewer points.

Oregon vs USC Prediction

Oregon just hasn’t played good ball this season and is fresh off a game against Minnesota where it scored 44 points. 44 points. Oregon was a 3.5-point favorite in that game. Oregon also hasn’t had any success on the road and is 8-18 ATS on the season. There’s not a lot of reason to get behind this Oregon team. USC beat Oregon on the road back in December and needs a strong performance after recent losses to Illinois and Ohio State. The line is reasonable. Oregon isn’t good. Give me the Trojans and the chalk.

Randy Chambers's Pick: USC -5.5

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