Notre Dame vs Louisville Prediction 2/4/2026 Today’s College Basketball Picks

The Notre Dame Fighting Irish and the Louisville Cardinals meet Wednesday in college basketball action from the KFC Yum! Center. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Notre Dame Fighting Irish vs. Louisville Cardinals prediction.

Notre Dame Fighting Irish Recap

The Notre Dame Fighting Irish come into this game looking to bounce back from an 86-72 loss at the hands of Syracuse last time out to sit at 11-11 this season. After this game, Notre Dame will head home for a game against Florida State.

Irish Drop 8 Of Last 10

Markus Burton leads the Irish in scoring with 18.5 PPG while Braeden Shrewsberry has 11.7 PPG with 2.9 RPG. Jalen Haralson has 15.5 PPG with 3.6 RPG and 2.6 APG and Cole Certa has 10.2 PPG to cap off the group of double-digit scorers for Notre Dame so far this season. Carson Towt’s added a team-high 9.5 RPG to lead the Irish in rebounding so far this season. As a team, Notre Dame is averaging 74 PPG on 45% shooting from the field, 35.2% from three and 69.9% from the foul line this season.

Louisville Cardinals Recap

The Louisville Cardinals come into this game looking to build on their 88-74 win over SMU last time out to sit at 15-6 this season. After this game, Louisville will head on the road for a game against Wake Forest.

Cardinals Win 3 Of Last 4

Ryan Conwell leads the Cardinals in scoring with 19.1 PPG along with 5 RPG and 2.6 APG while Mikel Brown Jr. has 16.4 PPG with a team-high 5 APG to lead the Cardinals in assists and 2.9 RPG. Isaac McKneely’s added 11.6 PPG with 3.1 RPG and Sananda Fru has 10.2 PPG with 6.7 RPG to lead the Cardinals in rebounding. J’Vonne Hadley has 10.8 PPG with 5.4 RPG to round out the group of double-digit scorers for Louisville so far this season.  Adrian Wooley’s added 9 PPG with 4 RPG and Khani Rooths has 6.5 PPG with 5.2 RPG this season. As a team, Louisville is averaging 86.1 PPG on 46.3% shooting from the field, 34.8% from three and 76.5% from the foul line this season.

Notre Dame Fighting Irish @ Louisville Cardinals Betting Trends: February 4, 2026

Why the Louisville Cardinals will win

• Louisville has won each of its last 33 games as an AP-ranked team against a non-AP-ranked team at KFC Yum! Center.
• Notre Dame has lost each of its last 12 games against AP-ranked opponents.
• Louisville has won the first half in each of its last nine night games at KFC Yum! Center against non-AP-ranked opponents.

Why the Notre Dame Fighting Irish will win

• Notre Dame has won four of its last five games against Louisville.
• Louisville has lost four of its last five games following a home win.
• Notre Dame has won the first half in three of its last four games against Louisville.

Total Points Facts

• Each of the last nine games between Notre Dame and Louisville have produced a total of 152 or fewer points.
• Thirty-one of Notre Dame’s last 36 night games against Conference opponents have produced a total of 151 or fewer points.

Matchup/League Facts

• Louisville ranks 4th among Division 1 teams for three-point field goal attempts per game this season (33.9).
• Louisville ranks 5th among Division 1 teams for three-point field goals made per game this season (11.8).
• Notre Dame ranks 363rd among Division 1 teams for steals per game this season (4.3).

Notre Dame Fighting Irish vs. Louisville Cardinals Prediction

I’m on Notre Dame and the points in this one. I just think that while Louisville has smash potential here, the Cardinals have a clunker from time to time, and as much as I don’t love Notre Dame, I think that this is too many points to give an Irish team that at time shows up here and there and could make a game of this. Give me Notre Dame.

Chris Ruffolo's Pick: Notre Dame +17.5