Louisville vs Duke Prediction 3/15/25 College Basketball Picks

The Louisville Cardinals and Duke Blue Devils meet Saturday in the college basketball ACC Final at the Spectrum Center. Here’s a Louisville vs Duke Prediction. This article will include a Louisville vs Duke Pick.

Louisville Cardinals Betting Preview 

The Louisville Cardinals recently beat Virginia Tech, Pitt, Cal, Stanford, and Clemson. Louisville has won 11 straight games and has lost just once since Christmas. 

The Louisville Cardinals are averaging 79.3 points on 45.6 percent shooting and allowing 68.5 points on 42.4 percent shooting. Chucky Hepburn is averaging 16.4 points and 3.5 rebounds, while Terrence Edwards Jr. is averaging 16.1 points and 3.9 rebounds. Reyne Smith is the third double-digit scorer and J’Vonne Hadley is grabbing 7.3 rebounds. The Louisville Cardinals are shooting 33.3 percent from beyond the arc and 74.9 percent from the free throw line. The Louisville Cardinals are allowing 33.3 percent shooting from deep and are grabbing 35.1 rebounds per game.

Duke Blue Devils Betting Preview 

The Duke Blue Devils recently beat Florida State, Wake Forest, North Carolina, and Georgia Tech. Duke has won 10 straight games and has a chance to lock up to the top seed in the NCAA Tournament. 

The Duke Blue Devils are averaging 83.5 points on 49.1 percent shooting and allowing 61.4 points on 38.2 percent shooting. Cooper Flagg is averaging 18.9 points and 7.5 rebounds, while Kon Knueppel is averaging 14.2 points and 3.9 rebounds. Tyrese Proctor is the third double-digit scorer and Sion James is grabbing 4.1 rebounds. The Duke Blue Devils are shooting 38.7 percent from beyond the arc and 78.4 percent from the free throw line. The Duke Blue Devils are allowing 30.8 percent shooting from deep and are grabbing 36.3 rebounds per game.

Louisville vs Duke Injury Report

Louisville will be without Kasean Pryor and Koren Johnson, while Reyne Smith is questionable with an ankle injury. Duke will be without Cooper Flagg due to an ankle injury. 

Louisville vs Duke Prediction

Duke beat Louisville back in December, but that game was three months ago, so I’m not sure how much stock we put into that. Duke is finding ways to win without Flagg, but is now 0-2 ATS in this tournament. Louisville is one of the more balanced teams in the country, which includes top-60 in scoring offense and top-100 in scoring defense and field goal percentage defense. Louisville is physical and tough, and not the sort of team you want to see when playing a third game in three days. This line is showing a lot of respect for Duke without its best player. Louisville is no pushover. I’ll take the Cards and the points.