Xavier Musketeers guard Malik Messina-Moore (1) drives against Santa Clara Broncos guard Christian Hammond (1) in the first half of the NCAA Men’s Basketball game between the Xavier Musketeers and the Santa Clara Broncos at the Cintas Center in Cincinnati on Monday, Nov. 10, 2025.
Sam Greene/The Enquirer / USA TODAY NETWORK via Imagn Images

Louisiana vs Santa Clara Prediction 11/21/2025 Today’s College Basketball Picks

Pick details

MATCHUP Louisiana Ragin' Cajuns Santa Clara Broncos
Team Records 1-4 5-0
Spread +19.5 -112 -19.5 -108
Moneyline +1600 -4000
Total Over 139.5 (-105) Under 139.5 (-115)
Where Leavey Center, Santa Clara, CA
When Friday, November 21, 2025
Time 10:00 PM EST
TV ESPN+

The Louisiana Ragin’ Cajuns and Santa Clara Broncos meet Friday in the college basketball action at the Leavey Center. Here’s a Louisiana vs Santa Clara Prediction. This article will include a Louisiana vs Santa Clara Pick.

Louisiana Ragin’ Cajuns Betting Preview


The Louisiana Ragin’ Cajuns lost to McNeese and Stanford, and they play UC Davis next. Louisiana has lost 3 straight games.

The Louisiana Ragin’ Cajuns are averaging 78 points on 42.2 percent shooting and allowing 93.5 points on 46.6 percent shooting. Jamyron Keller is averaging 17 points and 3 assists, while Jaxon Olvera is averaging 15.8 points and 5 rebounds. Dorian Finister is the third double-digit scorer and De’Vion Lavergne is grabbing 4.6 rebounds. The Louisiana Ragin’ Cajuns are shooting 30.1 percent from beyond the arc and 64.6 percent from the free throw line. The Louisiana Ragin’ Cajuns are allowing 36 percent shooting from deep and are grabbing 33.5 rebounds per game.

Santa Clara Broncos Betting Preview


The Santa Clara Broncos beat Nevada and Idaho State, and they play Saint Louis next. Santa Clara has won 12 of its last 16 games.

The Santa Clara Broncos are averaging 82.2 points on 47.4 percent shooting and allowing 65.2 points on 38.8 percent shooting. Christian Hammond is averaging 16.6 points and 4.8 rebounds, while Elijah Mahi is averaging 13.2 points and 3.8 rebounds. Bukky Oboye is the third double-digit scorer and Sash Gavalyugov is grabbing 1.6 rebounds. The Santa Clara Broncos are shooting 32.8 percent from beyond the arc and 63.5 percent from the free throw line. The Santa Clara Broncos are allowing 29.3 percent shooting from deep and are grabbing 38.6 rebounds per game.

Why the Santa Clara Broncos will win

  • Santa Clara has won each of its last 10 Friday night games against non-Conference opponents.
  • Louisiana has lost five of its last six games against non-AP-ranked opponents.

Matchup/League Facts

  • Santa Clara ranks 29th among Division 1 teams for assists per game this season (19.4).
  • Santa Clara ranks 33rd among Division 1 teams for assist to turnover ratio this season (1.80).
  • Louisiana ranks 363rd among Division 1 teams for opponent free throw attempts per game this season (32.0).
  • Louisiana ranks 362nd among Division 1 teams for assists per game this season (8.0).

Louisiana vs Santa Clara Prediction


Louisiana has had scoring issues so far this season, and things usually don’t turn around on the road. Louisiana has also failed to cover 5 of its last 7 games. Santa Clara looks great on both sides of the ball and has covered three of its first four games this season. Thick line, but Santa Clara has given us no reason to go against it, and Louisiana hasn’t shown much to get excited about. Two teams heading in different directions. I’ll lay the points with the Broncos.

Randy Chambers's Pick: Santa Clara -19.5

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