Nov 6, 2025; Louisville, Kentucky, USA;  Jackson State Tigers guard Daeshun Ruffin (24) scrambles for the ball with Louisville Cardinals forward Khani Rooths (9) during the second half at KFC Yum! Center. Louisville defeated Jackson State 106-70. Mandatory Credit: Jamie Rhodes-Imagn Images
Jamie Rhodes-Imagn Images

Kentucky vs Louisville Prediction 11/11/2025 Today’s College Basketball Picks

Pick details

MATCHUP Wildcats Kentucky Cardinals Louisville
Team Records 2-0 2-0
Spread +4.5 -110 -4.5 -110
Moneyline +150 -180
Total Over 175.5 (-105) Under 175.5 (-115)
Where KFC Yum! Center, Louisville, KY
When Tuesday, November 11, 2025
Time 08:00 PM EST
TV ESPN

The Kentucky Wildcats and Louisville Cardinals meet Tuesday in the college basketball action at the KFC Yum! Center. Here’s a Kentucky vs Louisville Prediction. This article will include a Kentucky vs Louisville Pick.

Kentucky Wildcats Betting Preview


The Kentucky Wildcats beat Nicholls and Valparaiso, and they play Eastern Illinois and Michigan State next. Kentucky has won 5 of its last 6 regular season games.

The Kentucky Wildcats are averaging 92 points on 50.8 percent shooting and allowing 55 points on 29.2 percent shooting. Collin Chandler is averaging 14.5 points and 3.5 rebounds, while Otega Oweh is averaging 14 points and 4 rebounds. Malachi Moreno is the third double-digit scorer and Denzel Aberdeen is dishing 4 assists. The Kentucky Wildcats are shooting 32.7 percent from beyond the arc and 70.8 percent from the free throw line. The Kentucky Wildcats are allowing 20.7 percent shooting from deep and are grabbing 43 rebounds per game.

Louisville Cardinals Betting Preview


The Louisville Cardinals beat South Carolina State and Jackson State, and they play Ohio and Cincinnati next. Louisville has won 13 of its last 14 regular season games.

The Louisville Cardinals are averaging 105 points on 52.7 percent shooting and allowing 57.5 points on 31.7 percent shooting. Khani Rooths is averaging 18 points and 8.5 rebounds, while Ryan Conwell is averaging 15.5 points and 5.5 rebounds. Mikel Brown Jr. is the third double-digit scorer and J’Vonne Hadley is grabbing 9 rebounds. The Louisville Cardinals are shooting 33.8 percent from beyond the arc and 76.5 percent from the free throw line. The Louisville Cardinals are allowing 28.3 percent shooting from deep and are grabbing 46 rebounds per game.

Why the Louisville Cardinals will win

  • Louisville has won each of its last eight night games at KFC Yum! Center.
  • Kentucky has lost three of its last four night games against AP-ranked opponents.
  • Kentucky has lost the first half in four of its last five night games against AP-ranked opponents.

Why the Kentucky Wildcats will win

  • Louisville has lost each of its last seven games against the Southeastern Conference.
  • Kentucky has won seven of its last eight games against the Atlantic Coast Conference.
  • Kentucky has won the first half in seven of its last eight games against non-Conference opponents.

Total Points Facts

  • Each of Kentucky’s last 11 night games have produced a total of 169 or fewer points.
  • One-hundred-forty of Louisville’s last 144 games against non-Conference opponents have produced a total of 174 or fewer points.

Matchup/League Facts

  • Louisville ranks T2nd for free throw percentage (87.5%) in last season’s NCAA Tournament.
  • Louisville ranks 3rd for fast break points per game (15.0) in last season’s NCAA Tournament.
  • Kentucky ranks 3rd for points off turnovers per game (18.3) in last season’s NCAA Tournament.
  • Kentucky ranks 5th for steals per game (8.7) in last season’s NCAA Tournament.

Kentucky vs Louisville Prediction


Louisville is going to get the benefit of the doubt because it’s at home and this is one of the more talented teams It’s had in a while. However, the value is with Kentucky and the points. As usual, Kentucky is one of the more talented teams in the country, and you’re not going to get the Wildcats as underdogs often the rest of the way. Kentucky has depth and has shown the ability to dig in defensively. Kentucky has won 8 of the last 10 games against Louisville and has outright won 10 of its last 16 games as an underdog. Any time I can get one of the best teams in the country in the plus money role, I’m going to take it, as it will pay off long term. Give me Kentucky.

Randy Chambers's Pick: Kentucky +4.5

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