USC vs Purdue Prediction 9/13/2025 Today’s College Football Picks

The USC Trojans and the Purdue Boilermakers meet in week 3 college football action from Ross-Ade Stadium on Saturday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a USC Trojans vs. Purdue Boilermakers prediction.

USC Trojans Recap

The USC Trojans come into this game looking to add on to their win over Georgia Southern by a final score of 59-20 last time out to improve to 2-0 on the year. After this game, USC will head home for a game against Michigan State.

Trojans Win Back-To-Back Blowouts

Jayden Maiava has thrown for 707 yards and 6 touchdowns on 73.8% passing while Husan Longstreet’s thrown for 103 yards and a TD on 86.7% passing. Waymond Jordan leads USC in rushing with 209 yards and 2 TDs while King Miller has 135 rushing yards and 2 touchdowns as well. Eli Sanders and the aforementioned Longstreet each have a pair of rushing TDs as well. Makai Lemon leads the Trojans in receiving with 11 catches for 248 yards and 2 touchdowns while Ja’Kobi Lane and Lake McRee each have 100+ receiving yards as well as a touchdown this season. On defense, Eric Gentry has a team-high 13 solo tackles while Kameryn Fountain, Braylan Shelby and Anthony Lucas all have a pair of sacks and as a team, USC has combined for 9 sacks and 3 interceptions.

Purdue Boilermakers Recap

The Purdue Boilermakers come into this game looking to add on to their 34-17 win over Southern Illinois last time out to sit at 2-0 as well this season. After this game, the Boilermakers will head on the road for a game against Notre Dame.

Boilermakers Looking For Huge Upset

Ryan Browne has thrown for 481 yards, 4 touchdowns and an interception on 65.3% passing while Devin Mockobee has rushed for 185 yards and 3 touchdowns. Arhmad Branch has 132 receiving yards and a pair of touchdowns as well this season to lead Purdue’s receiver room. On defense, Tahj Ra-El has a team-high 14 solo tackles while Jamarrion Harkless leads the Boilermakers’ defense which has combined for 7 sacks so far this season by putting up 1.5 sacks so far this year.

USC Trojans @ Purdue Boilermakers Betting Trends: Week 3

Why the Purdue Boilermakers will win

• USC has lost four of its last five games as a road favorite.
• The home team has won each of Purdue’s last four games.
• USC has failed to cover the spread in seven of its last eight games as a road favorite.

Why the USC Trojans will win

• USC has won each of its last 11 September games against non-AP-ranked teams.
• Purdue has lost each of its last nine games against conference opponents.
• Purdue has failed to cover the spread in seven of its last eight games in Indiana.
• USC has covered the spread in each of its last five games against non-AP-ranked teams.
• Purdue has lost the first half in each of its last eight games against conference opponents.

Total Points Facts

• Each of USC’s last four games have gone OVER the total points line.
• Four of Purdue’s last five home games against non-AP-ranked teams have gone UNDER the total points line.

Purdue Boilermakers Player Prop Facts

• Heading into Week 3, Devin Mockobee ranks T1st amongst qualified players for catch rate (100.0%) this season.

USC Trojans Player Prop Facts

• Makai Lemon has recorded 75+ receiving yards in four consecutive games – equal-longest streak in the FBS, heading into Week 3.

Matchup/League Facts

• Purdue ranks T1st among FBS teams for Q2 opponent points per game this season (0.0).
• Purdue ranks T1st among FBS teams for Q3 opponent points per game this season (0.0).
• USC ranks 1st among FBS teams for points per game this season (66.0).
• USC ranks T1st among FBS teams for Q4 opponent points per game this season (0.0).

USC Trojans vs. Purdue Boilermakers Prediction

I’m on USC here. I get the case to be made for Purdue, as Barry Odom has done a solid job of giving Purdue a couple of strong wins to start the year which is desperately needed for a program that went through it to say the least last season. However, USC, even though the Trojans haven’t had the most success going east over the years, still have the far more potent offense and I’m worried about Purdue having to go against a formidable team to test their defense. All in all, I think USC runs away with this one so give me the Trojans here.