Troy vs Clemson Prediction 9/6/2025 Today’s College Football Picks

In this article we will formulate a Troy vs Clemson prediction for this College Football game on Saturday, September 6th at Memorial Stadium in Clemson, South Carolina. Let’s take a look at the prediction for this week 2 matchup. 

Troy Trojans Betting Preview

The Troy Trojans are 1-0 this year after they defeated Nicholls by a score of 38-20 last week. Troy trailed 10-0 in the second quarter, but they cut that deficit to 10-7 at the half. The Trojans fell behind 17-7 in the third and 20-17 in the fourth, but they scored 21 points in the last eight minutes for the double-digit win. Troy out gained Nicholls by a total of 416-249, went 9-15 on third down conversions, and won the turnover battle by a total of 1-0 in the game. Goose Crowder went 14-24 for 144 yards and three touchdowns, Tae Meadows rushed 23 times for 186 yards and one touchdown, and Roman Mothershed caught two passes for 32 yards and one score in the win. The Troy defense recorded four sacks and eight tackles for loss in the game. 

Troy really struggled to create separation in this game, but they finally woke up and scored 28 points in the fourth quarter. The Trojans ran the ball very well with Meadows as the lead back, but Crowder was inefficient at the quarterback spot. The defense also has to be a concern, as giving up 20 points to an FCS school is not great. 

Clemson Tigers Betting Preview

The Clemson Tigers are 0-1 this season after they lost to LSU by a score of 17-10 in week one. Clemson led 3-0 after the first quarter and 10-3 at halftime, but they failed to score in the second half. The Tigers did have a chance at the end of the game, but they were stopped on fourth down near the red zone. Clemson was out gained by a total of 354-261, went 3-13 on third down conversions, and won the turnover battle by a margin of 2-1 in the loss. Cade Klubnik went 19-38 for 230 yards and one interception, Adam Randall rushed five times for 16 yards and one touchdown, and Bryant Wesco Jr. caught four passes for 66 yards in the game. The Clemson defense recorded one sack and eight tackles for loss in the defeat. 

Clemson’s defense played pretty well in their first game against LSU, but LSU eventually broke it down and found success. The Tigers have to be happy with only allowing 17 points in the game, but Klubnik and the offense were not good. This should be a spot for the offense to get right and I expect to see an emphasis on the rushing attack.  

Why Clemson will beat Troy

Clemson has won 42 of its last 44 games against non-AP-ranked teams at Memorial Stadium (Clemson).
Troy has lost each of its last four road games against AP-ranked teams.
Clemson has covered the spread in each of its last four games in September.

Total Points Facts

Seven of Troy’s last eight games against teams from South Carolina have gone OVER the total points line.
Four of Clemson’s last five games against opponents from the Sun Belt Conference have gone UNDER the total points line.

Matchup/League Facts

Clemson ranks 133rd among FBS teams for rushing yards per game this season (31.0).
Clemson ranks 127th among FBS teams for time of possession per game this season (22:50).
Troy ranks 1st among FBS teams for average point differential in fourth quarters this season (+25.0).
Troy ranks T1st among FBS teams for red zone percentage this season (100.0).

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Troy vs Clemson Prediction 

Clemson rolls into this matchup as a big favorite to get the win, as they look to bounce back after their week one loss. The Tigers should have plenty of success in this game and I would be surprised if Troy makes it to 14 points. The Clemson offense should do pretty much whatever it wants, but their rushing attack has to generate more yards. This is a great spot for Clemson to bounce back with a blowout victory, so I will take them to cover here.