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Southern Illinois vs Purdue Prediction 9/6/2025 Today’s College Football Picks
Pick details
Southern Illinois (1-0) vs Purdue (1-0)
September 6, 2025 at 07:30 PM EDT
The Line: Betting Odds: Purdue — Over/Under:
Southern Illinois and Purdue meet Saturday in college football action from Ross-Ade Stadium. Here’s a Southern Illinois vs Purdue prediction. We will look at this from a betting perspective and determine the best Southern Illinois Salukis and Purdue Boilermakers pick. We will examine:
The Southern Illinois Salukis’ recent form and player performance
The Purdue Boilermakers’ recent form and player performance
Recent betting trends and streaks involving the Southern Illinois Salukis
Recent betting trends and streaks involving the Purdue Boilermakers
Recent betting trends in games played between Southern Illinois and Purdue
A summary that ties it all together and produces a favorable betting outcome for the Salukis vs the Boilermakers game.
It’s still to be seen how good this Purdue team is going to be, but they sure looked impressive in the first game. Purdue faced off against the Ball State Cardinals, and they were able to secure the 31-0 victory. At halftime they were up 21-0, and in the second half they took their foot off the gas, but the defense still dominated. Ryan Browne completed 18 of his 26 passes for 311 yards and two touchdowns. Arhmand Branch finished with three catches for 101 yards and one touchdown. In this game, Purdue is going to need a more balanced offensive attack. Having a solid running game is going to be crucial going forward, and establishing it here is going to be key.
The home team has won each of Purdue’s last three games.
Purdue has covered the spread in four of its last five home games against non-FBS teams.
Southern Illinois faced off against Thomas More in the first game and they were able to secure the 49-3 victory. At halftime they were up 28-3, and they never looked back. DJ Williams completed 17 of his 24 passes for 227 yards, three touchdowns, and zero interceptions. Even though they won, they need a more balanced rushing attack. Lashaun Lester finished with nine carries for 39 yards. Vinson Davis was the top wide receiver, finishing with five catches for 86 yards. After this game, Southern Illinois is going to go on the road and face off against UT Martin. If they want to win this game, they are going to need the defense to step up and really put the pressure.
Purdue has lost six of its last seven games in Indiana.
Purdue has failed to cover the spread in six of its last seven home games against teams from Illinois.
Purdue dominated the first game, but I believe they are facing a better offense in Southern Illinois. They put up 49 points in the first game, and although they aren’t going to reach that number here, they are going to score enough. Williams threw for three touchdowns, and I don’t think the Purdue defense is as good as they looked in the first game. IT was only the first game, and when this season is over, we will be talking about the troubles of the Boilermakers defense. It might be one that you have to sweat out at the end, but Southern Illinois will end up covering the spread. Back Southern Illinois against the spread.
The Southern Illinois Salukis’ recent form and player performance
The Purdue Boilermakers’ recent form and player performance
Recent betting trends and streaks involving the Southern Illinois Salukis
Recent betting trends and streaks involving the Purdue Boilermakers
Recent betting trends in games played between Southern Illinois and Purdue
A summary that ties it all together and produces a favorable betting outcome for the Salukis vs the Boilermakers game.
Dominant First Game for Purdue
It’s still to be seen how good this Purdue team is going to be, but they sure looked impressive in the first game. Purdue faced off against the Ball State Cardinals, and they were able to secure the 31-0 victory. At halftime they were up 21-0, and in the second half they took their foot off the gas, but the defense still dominated. Ryan Browne completed 18 of his 26 passes for 311 yards and two touchdowns. Arhmand Branch finished with three catches for 101 yards and one touchdown. In this game, Purdue is going to need a more balanced offensive attack. Having a solid running game is going to be crucial going forward, and establishing it here is going to be key.
Why Purdue Will Beat Southern Illinois
The home team has won each of Purdue’s last three games.
Purdue has covered the spread in four of its last five home games against non-FBS teams.
Big Win for Southern Illinois
Southern Illinois faced off against Thomas More in the first game and they were able to secure the 49-3 victory. At halftime they were up 28-3, and they never looked back. DJ Williams completed 17 of his 24 passes for 227 yards, three touchdowns, and zero interceptions. Even though they won, they need a more balanced rushing attack. Lashaun Lester finished with nine carries for 39 yards. Vinson Davis was the top wide receiver, finishing with five catches for 86 yards. After this game, Southern Illinois is going to go on the road and face off against UT Martin. If they want to win this game, they are going to need the defense to step up and really put the pressure.
Why Southern Illinois Will Beat Purdue
Purdue has lost six of its last seven games in Indiana.
Purdue has failed to cover the spread in six of its last seven home games against teams from Illinois.
Southern Illinois vs Purdue Prediction
Purdue dominated the first game, but I believe they are facing a better offense in Southern Illinois. They put up 49 points in the first game, and although they aren’t going to reach that number here, they are going to score enough. Williams threw for three touchdowns, and I don’t think the Purdue defense is as good as they looked in the first game. IT was only the first game, and when this season is over, we will be talking about the troubles of the Boilermakers defense. It might be one that you have to sweat out at the end, but Southern Illinois will end up covering the spread. Back Southern Illinois against the spread.
