Sep 6, 2025; Athens, Ohio, USA; West Virginia Mountaineers running back Jahiem White (1) runs the ball and is tackled by Ohio Bobcats safety Adonis Williams Jr. (5) during the first quarter at Peden Stadium. Mandatory Credit: Ben Queen-Imagn Images

Pittsburgh vs West Virginia Prediction 9/13/2025 Today’s College Football Picks

Pick details

Pittsburgh (2-0) vs West Virginia (1-1)

September 13, 2025 at 03:30 PM EDT

The Line: Betting Odds: West Virginia +7.5 — Over/Under: +55.5

(Get latest betting odds)

The Pittsburgh Panthers and West Virginia Mountaineers meet Saturday in college football action at Milan Puskar Stadium. Here’s a Pittsburgh vs West Virginia Prediction. This article will include a Pittsburgh vs West Virginia Pick.

Pittsburgh Panthers Betting Preview

The Pittsburgh Panthers beat Duquesne and Central Michigan, and they play Louisville next. Pittsburgh has split its last 12 games. Eli Holstein is completing 70.6 percent of his passes for 519 yards, 8 touchdowns, and 2 interceptions. Raphael Williams Jr. and Cataurus Hicks have combined for 240 receiving yards and 4 touchdowns, while Desmond Reid has 6 receptions.

The Pittsburgh Panthers ground game is averaging 141 yards per contest, and Desmond Reid leads the way with 112 yards and 1 touchdown. Defensively, Pittsburgh is allowing 13 points and 212.5 yards per game. Rasheem Biles leads the Pittsburgh Panthers with 15 tackles, Kyle Louis has 2 sacks and Rashad Battle has 1 pass deflection.

West Virginia Mountaineers Betting Preview

The West Virginia Mountaineers beat Robert Morris, lost to Ohio, and they play Kansas next. West Virginia has split its last 12 games. Nicco Marchiol is completing 69.6 percent of his passes for 402 yards, 1 touchdown, and 1 interception. Cam Vaughn and Jaden Bray have combined for 265 receiving yards and 1 touchdown, while Grayson Barnes has 4 receptions.

The West Virginia Mountaineers ground game is averaging 232.5 yards per contest, and Jahiem White leads the way with 133 yards and 3 touchdowns. Defensively, West Virginia is allowing 10 points and 276 yards per game. Fred Perry leads the West Virginia Mountaineers with 15 tackles, Chase Wilson has 3 sacks and Darrian Lewis has 1 interception.

Pittsburgh Panthers @ West Virginia Mountaineers Betting Trends: Week 3

Why the West Virginia Mountaineers will win

  • West Virginia has won 19 of its last 20 September games at Milan Puskar Stadium.
  • Pittsburgh has lost six of its last eight games.
  • West Virginia has covered the spread in nine of its last 11 games as an underdog against non-AP-ranked teams.

Why the Pittsburgh Panthers will win

  • Pittsburgh has won each of its last four September games against non-AP-ranked teams.
  • West Virginia has lost three of its last four games against non-conference opponents.
  • Pittsburgh has covered the spread in each of its last four September games against non-AP-ranked teams.
  • West Virginia has failed to cover the spread in three of its last four games.

Total Points Facts

  • Each of Pittsburgh’s last 12 September games as a favorite against non-AP-ranked teams have gone OVER the total points line.
  • Four of West Virginia’s last five games as an underdog against non-AP-ranked teams have gone OVER the total points line.

West Virginia Mountaineers Player Prop Facts

  • Heading into Week 3, Jahiem White leads the Big 12 Conference for rushing touchdowns (3) this season.

Pittsburgh Panthers Player Prop Facts

  • Heading into Week 3, Josh Altsman ranks T1st amongst qualified players for catch rate (100.0%) this season.

Matchup/League Facts

  • West Virginia ranks T1st among FBS teams for H2 opponent points per game this season (0.0).
  • West Virginia ranks T1st among FBS teams for red zone percentage this season (100.0).
  • Pittsburgh ranks 6th among FBS teams for rushing yards allowed per game this season (38.5).
  • Pittsburgh ranks 131st among FBS teams for time of possession per game this season (23:57).

Pittsburgh vs West Virginia Prediction

Pittsburgh is the better team obviously as West Virginia has taken a step back these last couple of years and is coming off a bad loss to Ohio. However, we’re getting a home team and a free touchdown in a rivalry game. The underdog is 5-2-1 ATS in the last 8 games between Pittsburgh and West Virginia. Pittsburgh is 6-0 ATS as a road favorite of 5 or more points, but there’s value with points in a rivalry where teams are familiar with each other and don’t particularly like one another. I’ll grab the free touchdown with the Mountaineers.

Randy Chambers's Pick: West Virginia +7.5

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