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Ole Miss vs Kentucky Prediction 9/6/2025 Today’s College Football Picks
Pick details
Ole Miss (1-0) vs Kentucky (1-0)
September 6, 2025 at 03:30 PM EDT
The Line: Betting Odds: Kentucky +10 — Over/Under: +51.5
Ole Miss and Kentucky meet Saturday in college football action from Kroger Stadium. Here’s an Ole Miss vs Kentucky prediction. We will look at this from a betting perspective and determine the best Ole Miss Rebels vs Kentucky Wildcats pick. We will examine:
The Ole Miss Rebels’ recent form and player performance
The Kentucky Wildcats’ recent form and player performance
Recent betting trends and streaks involving the Rebels
Recent betting trends and streaks involving the Wildcats
Recent betting trends in games played between Ole Miss and Kentucky
A summary that ties it all together and produces a favorable betting outcome for the Ole Miss and Kentucky game.
Jaxson Dart has moved on to the New York Giants, but it appears the Ole Miss offense hasn’t lost a beat. The Rebels faced off against Georgia State in first game of the season, and they were able to secure the 63-7 victory. They only scored seven points in the first quarter, but the next three quarters they looked dominant on the way to the victory. Austin Simmons completed 20 of his 31 passes for 341 yards, three touchdowns, and two interceptions. The interceptions need to be cleaned up on, but the rest of the performance they have to be encouraged by. Running back Kewan Lacy finished with 16 carries for 108 yards and three touchdowns.
The defense also made life really tough on the Georgia State offense. They held Cameran Brown to only 17 yards through the air, and Christian Veillux completed only 4 of his 11 passes for 52 yards, one touchdown, and one interception.
Kentucky has lost each of its last seven games against conference opponents at Kroger Field.
Ole Miss has won six of its last seven games.
Kentucky has failed to cover the spread in six of its last seven games against conference opponents at Kroger Field.
The road team has covered the spread in five of Kentucky’s last six games.
It wasn’t the most dominant game for Kentucky against Toledo, but they ended up still securing the win 24-16. At halftime, they were up 10-2, and they scored 14 points in the 4th quarter which was enough. Zach Calzada was under for Kentucky and he completed 10 of his 23 passes for 85 yards, zero touchdowns, and one interception. The real bright spot for Kentucky was the running game, and he completed 14 carries for 129 yards and a touchdown. The running game is going to need to be good, but they really need to get a little more out of Calzada. If he struggles here, this is going to be a long game.
Kentucky has won four of its last six games as a home underdog against teams from Mississippi.
Kentucky has covered the spread in nine of its last 10 September games against AP-ranked teams.
The team ranked 20th in the AP Poll has failed to cover the spread in 10 of its last 13 games.
I was not impressed at all with Kentucky to start the season, and it’s not going to get any easier in this game. I am not sure Kentucky have their answer at quarterback with Calzada and he’s going to really struggle in this game against the Ole Miss defense. Compare that to Ole Miss, who has the real deal with Simmons at quarterback. He’s going to throw it up and down against the Kentucky defense, and the Rebels are going to cruise here. Back Ole Miss against the spread.
The Ole Miss Rebels’ recent form and player performance
The Kentucky Wildcats’ recent form and player performance
Recent betting trends and streaks involving the Rebels
Recent betting trends and streaks involving the Wildcats
Recent betting trends in games played between Ole Miss and Kentucky
A summary that ties it all together and produces a favorable betting outcome for the Ole Miss and Kentucky game.
Ole Miss Offense Hasn’t Changed
Jaxson Dart has moved on to the New York Giants, but it appears the Ole Miss offense hasn’t lost a beat. The Rebels faced off against Georgia State in first game of the season, and they were able to secure the 63-7 victory. They only scored seven points in the first quarter, but the next three quarters they looked dominant on the way to the victory. Austin Simmons completed 20 of his 31 passes for 341 yards, three touchdowns, and two interceptions. The interceptions need to be cleaned up on, but the rest of the performance they have to be encouraged by. Running back Kewan Lacy finished with 16 carries for 108 yards and three touchdowns.
The defense also made life really tough on the Georgia State offense. They held Cameran Brown to only 17 yards through the air, and Christian Veillux completed only 4 of his 11 passes for 52 yards, one touchdown, and one interception.
Why Ole Miss Will Beat Kentucky
Kentucky has lost each of its last seven games against conference opponents at Kroger Field.
Ole Miss has won six of its last seven games.
Kentucky has failed to cover the spread in six of its last seven games against conference opponents at Kroger Field.
The road team has covered the spread in five of Kentucky’s last six games.
Kentucky Pulled it Out
It wasn’t the most dominant game for Kentucky against Toledo, but they ended up still securing the win 24-16. At halftime, they were up 10-2, and they scored 14 points in the 4th quarter which was enough. Zach Calzada was under for Kentucky and he completed 10 of his 23 passes for 85 yards, zero touchdowns, and one interception. The real bright spot for Kentucky was the running game, and he completed 14 carries for 129 yards and a touchdown. The running game is going to need to be good, but they really need to get a little more out of Calzada. If he struggles here, this is going to be a long game.
Why Kentucky Will Beat Ole Miss
Kentucky has won four of its last six games as a home underdog against teams from Mississippi.
Kentucky has covered the spread in nine of its last 10 September games against AP-ranked teams.
The team ranked 20th in the AP Poll has failed to cover the spread in 10 of its last 13 games.
Ole Miss vs Kentucky Prediction
I was not impressed at all with Kentucky to start the season, and it’s not going to get any easier in this game. I am not sure Kentucky have their answer at quarterback with Calzada and he’s going to really struggle in this game against the Ole Miss defense. Compare that to Ole Miss, who has the real deal with Simmons at quarterback. He’s going to throw it up and down against the Kentucky defense, and the Rebels are going to cruise here. Back Ole Miss against the spread.
