Ohio vs Buffalo Prediction 11/28/2025 Today’s College Football Picks

In this article we will formulate an Ohio vs Buffalo prediction for this College Football game on Friday, November 28th at UB Stadium in Buffalo, New York. Let’s take a look at the prediction for this week 14 matchup. 

Ohio Bobcats Betting Preview

The Ohio Bobcats are 7-4 (5-2) this season after they defeated UMass by a score of 42-14 in their last game. Ohio led 21-7 at halftime and added 21 more points in the second half for the easy win. The Bobcats out gained UMass by a total of 391-215, went 6-14 on third downs, and won the turnover battle by a total of 3-1 in the game. Parker Navarro went 3-8 for 28 yards, while Sieh Bangura rushed 27 times for 196 yards and two scores. Eian Pugh led the receivers with one catch for 19 yards in the win. 

Prior to that game, Ohio lost to Western Michigan by a score of 17-13, but did beat Miami (OH) by a score of 24-20 before that. The Bobcats have won four of their last five games and they are currently tied for second in the MAC standings. Ohio has scored 28.5 points per game with 191.3 passing yards and 217.3 rushing yards per game, while they have allowed 22.6 points against per game this season. Parker Navarro has thrown for 2,085 yards, 12 touchdowns, and nine interceptions, while Sieh Bangura has rushed for 1,123 yards and 13 scores on 200 carries this season. 

Buffalo Bulls Betting Preview

The Buffalo Bulls are 5-6 (4-3) this year after they lost to Miami (OH) by a score of 37-20 last week. Buffalo trailed 17-10 at halftime, but did lead 20-17 in the third, before allowing the last 20 points in the loss. The Bulls out gained Miami (OH) by a total of 349-347, went 6-18 on third downs, and lost the turnover battle by a total of 3-0 in the game. Ta’Quan Roberson went 24-48 for 303 yards, two touchdowns, and two interceptions, while Terrance Shelton Jr rushed eight times for 27 yards. Nik McMillan led the receivers with eight catches for 147 yards in the loss. 

Prior to that game, Buffalo lost to Central Michigan by a score of 38-19, but did beat Bowling Green by a score of 28-3 before that. The Bulls have lost three of their last four games and they are currently sixth in the MAC standings. Buffalo has scored 23.8 points per game with 225.3 passing yards and 135.3 rushing yards per game, while they have allowed 22.8 points against per game this season. Ta’Quan Roberson has thrown for 2,250 yards, 15 touchdowns, and 11 interceptions, while Nik McMillan has 57 receptions for 859 yards and three scores this year. 

Why the Ohio Bobcats will win

• Ohio has won each of its last 11 November games as a favorite against non-AP-ranked teams.
• Buffalo has lost four of its last five games at UB Stadium.
• Buffalo has failed to cover the spread in eight of its last nine games against non-AP-ranked teams.
• Ohio has covered the spread in five of its last six games against Buffalo.

Total Points Facts

• Each of Ohio’s last six November road games against non-AP-ranked teams have gone UNDER the total points line.
• Each of the last four games between Ohio and Buffalo at UB Stadium have gone UNDER the total points line.

Matchup/League Facts

• Buffalo ranks T13th among FBS teams for H1 opponent points per game this season (8.5).
• Buffalo ranks T124th among FBS teams for average point differential in fourth quarters this season (-3.3).
• Ohio ranks 23rd among FBS teams for red zone percentage against this season (77.1).
• Ohio is one of only 25 FBS teams undefeated in home games this season (6-0).

Ohio vs Buffalo Prediction 

Ohio comes into this matchup right in the middle of the logjam for second in the MAC standings, so they can’t afford a loss here. The Bobcats have plenty of talent on their team, but they struggle on the road, where they are 1-4 this year. Buffalo has lost three of their last four games and they have allowed 37+ in each of their last two. Buffalo has done a good job of beating up on the bad teams in the MAC, but they struggle against the good teams. Take Ohio to get a rare cover on the road.

David Racey is 140-118 (54%) in College Football this season and is one of the top College Football Handicappers on the site. Click here for his premium plays for the week!

David Racey's Pick: Ohio -7