Michigan vs Oklahoma Prediction 9/6/2025 Today’s College Football Picks

The Michigan Wolverines and the Oklahoma Sooners meet in week 2 college football action from Memorial Stadium on Saturday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Michigan Wolverines vs. Oklahoma Sooners prediction.

Michigan Wolverines Recap

The Michigan Wolverines come into this game looking to build on their season-opening 34-17 win over New Mexico last time out to improve to 1-0 this season. After this game, the Wolverines will head home for a game against Central Michigan.

Wolverines Looking To Pick Up Marquee Road Win

Bryce Underwood threw for 251 yards and a touchdown on 21 of 31 passing while Justice Haynes rushed for 159 yards and 3 TDs on 16 carries. Marlin Klein led the Wolverines in receiving with 6 grabs for 93 yards and a touchdown while Channing Goodwin had 49 receiving yards as well in the win. On defense, Ernest Hausmann led the Wolverines with 8 total tackles including 5 solo tackles while Cole Sullivan added a sack and Troy Bowles chipped in a sack as well as Dominic Nichols. TJ Guy, Brandyn Hillman and the aforementioned Sullivan all contributed an interception for the Wolverines as well in the victory.

Why the Michigan Wolverines will win

• Michigan has won 17 of its last 18 games in September.
• Oklahoma has lost four of its last five games against AP-ranked teams.
• Michigan has covered the spread in four of its last five games.
• Oklahoma has failed to cover the spread in four of its last five games.

Oklahoma Sooners Recap

The Oklahoma Sooners come into this game looking to build on their 35-3 win over Illinois State to start the year 1-0. After this game, Oklahoma will head on the road for a game against the Temple Owls.

Sooners Looking To Defend Home Turf

John Mateer threw for 392 yards, 3 touchdowns and an INT on 30 of 37 passing while Tory Blaylock led the Sooners on the ground with 44 rushing yards and a touchdown and Mateer also added 24 rushing yards and a touchdown as well. Keontez Lewis chipped in 9 grabs for 119 yards and 2 touchdowns while Jaren Kanak had 5 receptions for 90 receiving yards and Deion Burks added 7 grabs for 88 yards and a touchdown in the win. On defense, Sammy Omosigho had a team-high 8 total tackles including a sack while Taylor Wein also had a sack for the Sooners in the win. 

Why the Oklahoma Sooners will win

• Oklahoma has won each of its last 13 games as a favorite against top-15 AP-ranked teams.
• Michigan has lost three of its last four road games.
• Oklahoma has covered the spread in each of its last four games as a favorite against top-15 AP-ranked teams.
• Michigan has failed to cover the spread in six of its last seven September games as an underdog.

Total Points Facts

• Seven of Oklahoma’s last eight games against AP-ranked teams at Oklahoma Memorial Stadium have gone UNDER the total points line.
• Five of Michigan’s last six road openers have gone OVER the total points line.

Michigan Wolverines vs. Oklahoma Sooners Prediction

I’m on the under in this one. I get the case to be made for either side in this game, but I still this you have two top-tier defenses, two coaches that can ground and pound as Sherrone Moore is great at coaching his lines and Will Venable is a defensive mastermind as well, and I really think we’re headed for a low-scoring battle here. Give me the under.