Oct 11, 2025; Los Angeles, California, USA; Michigan Wolverines tight end Marlin Klein (17) hangs on to the ball after a complete pass as he is stopped by USC Trojans linebacker Eric Gentry (18) in the second half at United Airlines Field at the Los Angeles Memorial Coliseum. Mandatory Credit: Jayne Kamin-Oncea-Imagn Images
IMAGN IMAGES via Reuters Connect

Louisiana vs USC Prediction 9/12/2026 Today’s College Football Picks

Pick details

MATCHUP Louisiana Ragin' Cajuns USC Trojans
Team Records 1-0 2-0
Spread +31.5 -115 -31.5 -105
Moneyline +2500 -9000
Total Over 59.5 (-105) Under 59.5 (-115)
Where Los Angeles Memorial Coliseum, Los Angeles, CA
When Saturday, September 12, 2026
Time 11:00 PM EDT
TV BTN

In this article, we will formulate a Louisiana vs USC Prediction for this College Football Week 2 matchup on Saturday, September 12th. Let’s take a look at the prediction for this College Football matchup.

USC Trojans Preview


The USC Trojans have a 2-0 record this season and are coming off a 39-0 home victory over Fresno State, where they outgained their opponents 552-116 yards and had 68 total plays. USC had 412 passing yards, 140 rushing yards, and 29/31 completed passes. The turnover battle was tied 2-2, they were 5/8 on third down conversions, and had 5-44 penalties.

Jayden Maiava led USC with 23/25 passes, 349 passing yards, and 3 touchdowns. Woody Jordan had a team-high 67 rushing yards and 1 touchdown, while Trent Mosley caught 4 passes for a team-high 104 receiving yards and 2 touchdowns. Defensively, Kennedy Urlacher led the Trojans with 2 sacks among his 3 total tackles, while Desman Bryant recorded 4 total tackles.

Louisiana Ragin’ Cajuns Preview


The Louisiana Ragin’ Cajuns have a 1-0 record this season and are coming off a 38-7 home victory over Lamar, where they outgained their opponents 474-205 yards and had 69 total plays. Louisiana had 231 passing yards, 243 rushing yards, and 20/28 completed passes. They won the turnover battle by 3-4, were 3/8 on third down conversions, and had 6-48 penalties.

Lunch Winfield led Louisiana with 16/22 passes and 189 passing yards. Darrell Smith had a team-high 84 rushing yards, while Caden Jensen caught 5 passes for a team-high 77 receiving yards. Defensively, Brent Gordon Jr. led the Ragin’ Cajuns with 7 total tackles, 3 of them solo, while Avery Demery recorded one sack.

Louisiana Ragin’ Cajuns @ USC Trojans Betting Trends: Week 2


Why the USC Trojans will win

  • USC has won each of its last 18 home games as an AP-ranked team against a non-AP-ranked team.
  • Louisiana has lost four of its last five road openers.
  • USC has covered the spread in each of its last seven September home games as a top-15 AP-ranked team.
  • Louisiana has failed to cover the spread in four of its last five road openers.
  • USC has won the first half in 10 of its last 11 games against non-conference opponents at Los Angeles Memorial Coliseum.
  • USC has won the first quarter in each of its last six games against non-conference opponents.

Why the Louisiana Ragin’ Cajuns will win

  • Louisiana has won each of its last three games as an underdog.
  • USC has failed to cover the spread in five of its last six games.
  • The underdog has covered the spread in five of Louisiana’s last six games.
  • Louisiana has won the first half in three of its last four September games as a road underdog.

Total Points Facts

  • Each of Louisiana’s last six September games as an underdog have gone OVER the total points line.
  • Four of USC’s last five games against non-conference opponents at Los Angeles Memorial Coliseum have gone OVER the total points line.

USC Trojans Player Prop Facts

  • Heading into Week 2, Jayden Maiava ranks 1st amongst FBS players for passing yards (635) this season.

Louisiana Ragin’ Cajuns Player Prop Facts

  • Heading into Week 2, Teddy Gawlik ranks T1st amongst qualified players for catch rate (100.0%) this season.

Matchup/League Facts

  • USC ranks T1st among FBS teams for Q1 opponent points per game this season (0.0).
  • USC ranks T1st among FBS teams for Q2 opponent points per game this season (0.0).
  • Louisiana ranks T1st among FBS teams for Q1 opponent points per game this season (0.0).
  • Louisiana ranks T1st among FBS teams for Q2 opponent points per game this season (0.0).

Louisiana vs USC Prediction


In this Louisiana vs USC Prediction, USC is coming as -31.5 home favorites. Both teams have been undefeated this season and USC will play its third straight game at home to start the season. Both offenses are looking good so far, with USC averaging 40.5 points per game and Louisiana having scored 38 in its season opener. Louisiana finished last season 5-1 to the over and I expect a high-scoring game today between two efficient offensive lines. The over is high for a reason, so take the over 59.5 points in this one. 

Nikos Lagouretos's Pick: Over 59.5

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