Kentucky vs Louisville Prediction 11/29/2025 Today’s College Football Picks

In this article we will formulate a Kentucky vs Louisville prediction for this College Football game on Saturday, November 29th at L&N Federal Credit Union Stadium in Louisville, Kentucky. Let’s take a look at the prediction for this week 14 matchup. 

Kentucky Wildcats Betting Preview

The Kentucky Wildcats are 5-6 (2-6) this year after they lost to Vanderbilt by a score of 45-17 in their last game. Kentucky trailed 24-3 at halftime and allowed 21 points in the third quarter to seal the loss. The Wildcats were out gained by a total of 604-315, went 6-15 on third downs, and lost the turnover battle by a total of 3-1 in the game. Cutter Boley went 26-44 for 280 yards, two touchdowns, and two interceptions, while Seth McGowan rushed 10 times for 27 yards. Willie Rodriguez led the receivers with six catches for 78 yards in the loss. 

Prior to that game, Kentucky defeated Tennessee Tech by a score of 42-10 and Florida by a score of 38-7. The Wildcats have won three of their last four games and they are currently tied for 11th in the SEC standings. Kentucky has scored 25.1 points per game with 211.2 passing yards and 148.2 rushing yards per game, while they have allowed 25.1 points against per game this season. Cutter Boley has thrown for 2,060 yards, 15 touchdowns, and 10 interceptions, while Seth McGowan has rushed 163 times for 720 yards and 12 scores this year. 

Louisville Cardinals Betting Preview

The Louisville Cardinals are 7-4 (4-4) this season after they lost to SMU by a score of 38-6 in their last game. Louisville cut the deficit to 7-3 in the first quarter, but they allowed 31 of the last 34 points in the blowout loss. The Cardinals were out gained by a total of 485-228, went 3-12 on third downs, and lost the turnover battle by a total of 1-0 in the game. Deuce Adams went 12-17 for 94 yards, while Shaun Boykins Jr rushed eight times for 52 yards. Chris Bell led the receivers with five receptions for 46 yards in the loss. 

Prior to that game, Louisville lost to Clemson by a score of 20-19 and California by a score of 29-26. The Cardinals have lost three games in a row and they are currently tied for eighth in the ACC standings. Louisville has scored 29.2 points per game with 230.3 passing yards and 153.9 rushing yards per game, while they have allowed 23.0 points against per game this season. Miller Moss is dealing with an injury, so we may see Deuce Adams or Brady Allen under center, while Chris Bell has 72 receptions for 917 yards and six scores this season. 

Why the Kentucky Wildcats will win

• Kentucky has won each of its last three games as a road underdog against Louisville.
• Louisville has lost three of its last four November games as a home favorite.
• Louisville has failed to cover the spread in each of its last seven games at L&N Federal Credit Union Stadium.
• Kentucky has covered the spread in each of its last five games at L&N Federal Credit Union Stadium.

Total Points Facts

• Six of Kentucky’s last seven games as an underdog against Louisville have gone OVER the total points line.
• Five of the last six games between Kentucky and Louisville have gone OVER the total points line.

Matchup/League Facts

• Louisville ranks T23rd among FBS teams for H2 opponent points per game this season (9.0).
• Louisville ranks 23rd among FBS teams for 1st downs against this season (190).
• Kentucky ranks T19th among FBS teams for interceptions this season (12).
• Kentucky ranks 23rd among FBS teams for average point differential in fourth quarters this season (+3.5).

Kentucky vs Louisville Prediction 

Louisville comes into this matchup trying to snap a three game losing streak and they were dominated last week against SMU. The Cardinals have scored just 25 points in their last two games and they are dealing with an injury to their starting quarterback. Kentucky has won three of their last four games, but they did allow 45 points to Vanderbilt last week. The Wildcats need to win this game to gain bowl eligibility and I think this game is very winnable for them. It is tough to know if Moss will play or not, but I am going to assume he is out. Take Kentucky to cover here.

David Racey is 140-118 (54%) in College Football this season and is one of the top College Football Handicappers on the site. Click here for his premium plays for the week!

David Racey's Pick: Kentucky +3