Indiana Hoosiers defensive back Bryson Bonds (24) and Indiana Hoosiers linebacker Jeff Utzinger (34) watch the second half of a game between the Indiana Hoosiers and the Notre Dame Fighting Irish in first round of the College Football Playoff on Saturday, Dec. 21, 2024, in South Bend. Notre Dame defeated Indiana 27-17.

Kennesaw State vs Indiana Prediction 9/6/2025 Today’s College Football Picks

Pick details

Kennesaw State (0-1) vs Indiana (1-0)

September 6, 2025 at 12:00 PM EDT

The Line: Betting Odds: Indiana -36.5 — Over/Under: +50.5

(Get latest betting odds)

In this article, we will formulate a Kennesaw State vs Indiana Prediction for this College Football Week 2 game on Saturday, September 6th at the Memorial Stadium (Bloomington, IN). Let’s take a look at the prediction for this College Football matchup.

Kennesaw State Owls Preview

The Owls are coming off a 9-10 road defeat in Wake Forest in their season opener. Kennesaw State got outgained by their opponents by 348-307 yards. They had 12/33 completed passes, 149 passing yards, 158 rushing yards, with both teams being 0-0 in turnovers. The Owls went 9-19 in third down efficiency and had 9-68 penalties.

Dexter Williams II had 12/33 passes, a team-high 149 passing yards. Coleman Bennett added a team-high 66 rushing yards and one touchdown. The Owls did not have any interceptions in this game.

Indiana Hoosiers Preview

The Hoosiers are coming off a 27-14 home victory over Old Dominion in their season opener. Indiana outgained their opponents by 502-314 yards. They had 18/32 completed passes, 193 passing yards, 309 rushing yards, with turnovers being 1-3. The Hoosiers went 10-17 in third down efficiency and had 3-25 penalties.

Fernando Mendoza had 18/31 passes, a team-high 193 passing yards. Roman Hemby added a team-high 111 rushing yards, while Omar Cooper Jr. caught 2 passes for 52 yards. Defensively, Jacob Mangum-Farrar had seven total tackles, three of them solo, while Lanell Carr had one sack. The Hoosiers did not have any interceptions in this game.

Why the Indiana Hoosiers will win

  • Indiana has won each of its last 12 games against non-AP-ranked teams.
  • Indiana has covered the spread in five of its last six September games at Memorial Stadium (Bloomington).
  • Kennesaw State has failed to cover the spread in three of its last four games against non-conference opponents.
  • Indiana has won the first half in each of its last six games against non-conference opponents at Memorial Stadium (Bloomington).
  • Indiana has won the first quarter in four of its last five games against opponents from the Conference USA.

Why the Kennesaw State Owls will win

  • Indiana has failed to cover the spread in each of its last four games against opponents from the Conference USA.
  • Kennesaw State has covered the spread in three of its last four games.
  • Indiana has lost the first half in three of its last four home games against opponents from the Conference USA.

Total Points Facts

  • Each of Indiana’s last six games in September have gone OVER the total points line.
  • Each of Kennesaw State’s last five games against non-conference opponents have gone UNDER the total points line.

Matchup/League Facts

  • Indiana ranks T1st among FBS teams for Q2 opponent points per game this season (0.0).
  • Indiana ranks T1st among FBS teams for Q3 opponent points per game this season (0.0).
  • Kennesaw State ranks T1st among FBS teams for Q2 opponent points per game this season (0.0).
  • Kennesaw State ranks T1st among FBS teams for Q4 opponent points per game this season (0.0).

Kennesaw State vs Indiana Prediction

This will be the first meeting between those two teams.

In this Kennesaw State vs Indiana Prediction, Indiana is coming in as -35-point home favorites, with the total set at 52.5 points. Both teams are coming off opposite outcomes in their opening games of the season, with both games being low-scoring ones, with 19 and 41 total points. Both teams played excellent defense, with 24 points allowed combined, and Kennesaw State struggled on the offensive end with just 9 points. Indiana was a perfect 8-0 at home last season and a strong 9-3 against the spread, so I expect them to dominate an inferior Kennesaw State team today and cover the big spread at home.

Nikos Lagouretos's Pick: Indiana -36.5

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