Louisiana-Monroe Warhawks running back Ahmad Hardy (22) runs the ball as Auburn Tigers take on Louisiana-Monroe Warhawks at Jordan-Hare Stadium in Auburn, Ala., on Saturday, Nov. 16, 2024. Auburn Tigers defeated Louisiana-Monroe Warhawks 48-14.

Kansas vs Missouri Prediction 9/6/2025 Today’s College Football Picks

Pick details

Kansas (2-0) vs Missouri (1-0)

September 6, 2025 at 03:30 PM EDT

The Line: Betting Odds: Missouri -6.5 — Over/Under: +50.5

(Get latest betting odds)

The Kansas Jayhawks and Missouri Tigers meet Saturday in college football action at Memorial Stadium. Here’s a Kansas vs Missouri Prediction. This article will include a Kansas vs Missouri Pick.

Kansas Jayhawks Betting Preview


The Kansas Jayhawks beat Fresno State and Wagner, and they play West Virginia next. Kansas has won 5 of its last 6 games. Jalon Daniels is completing 80 percent of his passes for 456 yards, 7 touchdowns, and 1 interception. Emmanuel Henderson Jr. and Cam Pickett have combined for 260 receiving yards and 5 touchdowns, while Boden Groen has 3 receptions.

The Kansas Jayhawks’ ground game is averaging 331 yards per contest, and Daniel Hishaw Jr. leads the way with 158 yards and 1 touchdown.

Defensively, Kansas is allowing 7 points and 179.5 yards per game. Trey Lathan leads the Kansas Jayhawks with 12 tackles, DJ Withers has 2 sacks and Lyrik Rawls has 1 interception.

Missouri Tigers Betting Preview


The Missouri Tigers beat Central Arkansas, and they play Louisiana and South Carolina next. The Missouri Tigers have won 4 straight games. Beau Pribula is completing 82.1 percent of his passes for 283 yards, 2 touchdowns, and 0 interceptions. Marquis Johnson and Joshua Manning have combined for 187 receiving yards and 1 touchdown, while Kevin Coleman Jr. has 6 receptions.

The Missouri Tigers ground game is averaging 219 yards per contest, and Ahmad Hardy leads the way with 100 yards and 1 touchdown. Defensively, Missouri is allowing 6 points and 227 yards per game. Josiah Trotter leads the Missouri Tigers with 8 tackles, Damon Wilson II has 2 sacks and Dante McClellan has 1 interception.

Kansas vs Missouri Prediction


The Missouri Tigers are going to get the benefit of the doubt because they’re at home and the SEC program. I get it, I guess. However, Kansas isn’t the same school it was a few years ago. Kansas has improved greatly under coach Lance Leipold and has above-average talent at key positions. Jalon Daniels is a Heisman sleeper and can really put his name in the ring with a strong performance in games like this.

When you have a difference maker at quarterback, your team is always a live dog. In fact, Kansas is 8-2 ATS in its last 10 games as an underdog. Kansas has outright won its last three games as a dog. This isn’t your old Kansas team that others use as a punching bag. Give me the points.

Randy Chambers's Pick: Kansas +6.5

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