Grambling vs Ohio State Prediction 9/6/2025 Today’s College Football Picks

In this article we will formulate a Grambling vs Ohio State prediction for this College Football game on Saturday, September 6th at Ohio Stadium in Columbus, Ohio. Let’s take a look at the prediction for this week 2 matchup. 

Grambling Tigers Betting Preview

The Grambling Tigers are 1-0 this year after they defeated Langston by a score of 55-7 last week. Grambling dominated this game, as they led 14-0 after the first quarter and 35-0 at halftime. The Tigers only managed 20 points in the second half, as they put it on cruise control to finish. Grambling out gained Langston by a total of 466-97, went 7-14 on third down conversions, and won the turnover battle by a margin of 3-1. C’zavian Teasett went 20-25 for 203 yards and three touchdowns, while Ashton Frye went 6-8 for 44 yards and one touchdown. Tre Bradford carried the ball six times for 56 yards and one score, while Tyson George caught three passes for 63 yards and one touchdown. 

Ohio State Buckeyes Betting Preview

The Ohio State Buckeyes are 1-0 this season after they defeated Texas by a score of 14-7 in their first game. Ohio State scored the only points in the first half, as they led 7-0 at halftime, which was also the score heading into the fourth. The Buckeyes extended their lead to 14-0 early in the final quarter, but they allowed a late score and had to get a stop to seal the win. Ohio State was out gained by a total of 336-203, went 3-12 on third down conversions, and won the turnover battle by a margin of 1-0. Julian Sayin went 13-20 for 126 yards and one touchdown, while CJ Donaldson rushed 19 times for 67 yards and one score. Carnell Tate caught two passes for 49 yards and one touchdown, while Jeremiah Smith added six catches for 43 yards. The OSU defense was led by Davison Igbinosun, who had 10 total tackles, while the team had one sack and one tackle for loss. 

Ohio State didn’t play very well offensively in their season opener, but their defense was lights out and allowed them to play very conservatively in Sayin’s first start. The Buckeyes should have one of the best defenses in the country this season and they have one of the best wide receivers, but the quarterback and running back spots are a bit of a question mark.

Why Grambling will beat Ohio State

Ohio State has failed to cover the spread in three of its last four games against non-AP-ranked teams.

Total Points Facts

Each of Ohio State’s last four home games against non-AP-ranked teams have gone UNDER the total points line.

Matchup/League Facts

Ohio State ranks T1st among FBS teams for Q3 opponent points per game this season (0.0).
Ohio State ranks T1st among FBS teams for H1 opponent points per game this season (0.0).

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Grambling vs Ohio State Prediction 

Ohio State will be able to take a deep breath coming into this game, after last week’s battle with Texas, and they should pick up a very easy win here. The Buckeyes will do whatever they want on both sides of the ball, while Grambling will struggle to put up any points. The Tigers need to force some turnovers to generate good field position, but I just don’t see that happening. Ohio State is going to win this game easily, but I am going to take Grambling and the points, as I think OSU will really slow down in the second half.