Florida State vs Clemson Prediction 11/8/2025 Today’s College Football Picks

The Florida State Seminoles and Clemson Tigers meet Saturday in college football action at Memorial Stadium. Here’s a Florida State vs Clemson Prediction. This article will include a Florida State vs Clemson Pick.

Florida State Seminoles Betting Preview

The Florida State Seminoles lost to Stanford, beat Wake Forest, and they play Virginia Tech next. Florida State has lost 4 of its last 5 games. Tommy Castellanos is completing 61.5 percent of his passes for 1,878 yards, 10 touchdowns, and 5 interceptions. Duce Robinson and Micahi Danzy have combined for 1,192 receiving yards and 6 touchdowns, while Lawayne McCoy has 13 receptions.

The Florida State Seminoles ground game is averaging 241.3 yards per contest, and Gavin Sawchuk leads the way with 432 yards and 8 touchdowns. Defensively, Florida State is allowing 20.6 points and 316 yards per game. Earl Little Jr. leads the Florida State Seminoles with 52 tackles, Mandrell Desir has 3 sacks and Jerry Wilson has 2 interceptions.

Clemson Tigers Betting Preview

The Clemson Tigers lost to SMU and Duke, and they play Louisville next. Clemson has lost 4 of its last 6 games. Cade Klubnik is completing 67.2 percent of his passes for 1,915 yards, 13 touchdowns, and 5 interceptions. Bryant Wesco Jr. and T.J. Moore have combined for 1,036 receiving yards and 10 touchdowns, while Antonio Williams has 33 receptions.

The Clemson Tigers ground game is averaging 123.8 yards per contest, and Adam Randall leads the way with 522 yards and 6 touchdowns. Defensively, Clemson is allowing 24 points and 350.3 yards per game. Sammy Brown leads the Clemson Tigers with 58 tackles, Will Heldt has 4 sacks and Ricardo Jones has 3 interceptions.

Why the Clemson Tigers will win

• Clemson has won 43 of its last 48 games against non-AP-ranked teams at Memorial Stadium (Clemson).
• Florida State has lost four of its last five games.
• Florida State has failed to cover the spread in five of its last six games against conference opponents.
• The favorite has covered the spread in three of Florida State’s last four games at Memorial Stadium (Clemson).

Why the Florida State Seminoles will win

• Clemson has lost each of its last three games as a home favorite.
• The road team has won each of Clemson’s last five games.
• Clemson has failed to cover the spread in each of its last nine games at Memorial Stadium (Clemson).
• The road team has covered the spread in each of Clemson’s last five games.

Total Points Facts

• Each of Florida State’s last seven November games as an underdog against non-AP-ranked teams have gone UNDER the total points line.
• Five of Clemson’s last six November home games against non-AP-ranked teams have gone OVER the total points line.

Clemson Tigers Player Prop Facts

• Heading into Week 11, Bryant Wesco Jr. ranks T1st in the Atlantic Coast Conference for receiving touchdowns (6) this season.

Florida State Seminoles Player Prop Facts

• Heading into Week 11, Micahi Danzy is one of only three players averaging over 20.0 rushing yards and 60.0 receiving yards per game this season.

Matchup/League Facts

• Clemson ranks 109th among FBS teams for rushing yards per game this season (123.8).
• Clemson ranks T32nd among FBS teams for Q3 opponent points per game this season (3.9).
• Florida State ranks 1st among FBS teams for yards per game this season (510.5).
• Florida State ranks T4th among FBS teams for Q2 points per game this season (13.4).

Florida State vs Clemson Prediction

You can argue Florida State has had the better team and is the better team entering this game. However, the truth is I want nothing to do with either of these teams. Clemson has been the biggest underachiever on the season and is 2-6 ATS. With all of that said, we’re getting Clemson at home in a pick em spot, and Memorial Stadium is one of the toughest places in the country to play. This will be just the fourth time since 2011 where Clemson is a home favorite of 3 or fewer points. You don’t get this chance often. I’ll ride with Clemson on Saturday afternoon.

Randy Chambers's Pick: Clemson -1.5