Colorado vs Houston Prediction 9/12/2025 Today’s College Football Picks

The Colorado Buffaloes and the Houston Cougars meet in week 3 college football action from TDECU Stadium on Friday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Colorado Buffaloes vs. Houston Cougars prediction.

Colorado Buffaloes Recap

The Colorado Buffaloes come into this game looking to build on their 31-7 win over Delaware last time out to sit at 1-1 on the year. After this game, the Buffaloes will head home for a game against the Wyoming Cowboys.

Buffaloes Looking To Build On Opening Win

Kaidon Salter has thrown for 261 yards and a touchdown on 68.2% passing while Ryan Staub has thrown for 157 yards and 2 TDs on 7 of 10 passing. Simeon Price leads the Buffs with 85 rushing yards while Micah Welch has 78 rushing yards with a TD and Kaidon Salter has 68 rushing yards and 2 TDs. Sincere Brown has 120 receiving yards and a touchdown to lead Colorado while Dekalon Taylor has a team-high 7 receptions for 87 yards and 2 touchdowns. On defense, Reginald Hughes has a team-high 14 total tackles including 8 solo tackles while Colorado’s defense as a whole has combined for 3 sacks and 2 interceptions this season. 

Houston Cougars Recap

The Houston Cougars come into this game looking to add on to their 35-9 win over Rice last time out to sit at 2-0 on the year. After this game, Houston will head on the road for a game against the Oregon State Beavers.

Cougars Looking To Remain Unbeaten

Connor Weigman has thrown for 347 yards and 4 touchdowns on 65.2% passing while Dean Connors has rushed for 182 yards and 2 TDs on the ground this season. Tanner Koziol has a team-high 13 catches for 115 yards and a touchdown to lead Houston’s receiving group. On defense, Jalen Garner and Latrell McCutchin Sr. each have a team-high 13 total tackles while Brandon Mack II has a team-high 1.5 sacks. As a unit, Houston’s defense has combined for 5 sacks and 3 interceptions so far this season.

Colorado Buffaloes @ Houston Cougars Betting Trends: Week 3

Why the Houston Cougars will win

• Houston has won five of its last six games in Texas.
• Colorado has lost 25 of its last 32 road games against conference opponents.
• Colorado has failed to cover the spread in six of its last seven September games as an underdog against non-AP-ranked teams.
• Houston has covered the spread in five of its last six games in Texas.
• Colorado has lost the first half in 12 of its last 14 road games against conference opponents.

Why the Colorado Buffaloes will win

• Colorado has won each of its last four games in September.
• Houston has lost each of its last three games against conference opponents.
• Colorado has covered the spread in nine of its last 11 games against conference opponents.
• Houston has lost the first half in each of its last four games against conference opponents.

Total Points Facts

• Each of Houston’s last seven home games have gone UNDER the total points line.
• Each of Colorado’s last five games have gone UNDER the total points line.

Houston Cougars Player Prop Facts

• Heading into Week 3, Dean Connors ranks T1st amongst qualified players for catch rate (100.0%) this season.

Colorado Buffaloes Player Prop Facts

• Heading into Week 3, Isaiah Hardge ranks T1st amongst qualified players for catch rate (100.0%) this season.

Matchup/League Facts

• Houston ranks T1st among FBS teams for Q1 opponent points per game this season (0.0).
• Houston ranks T1st among FBS teams for Q3 opponent points per game this season (0.0).
• Colorado ranks T1st among FBS teams for Q1 opponent points per game this season (0.0).
• Colorado ranks T1st among FBS teams for 4th down conversion percentage this season (100.0).

Colorado Buffaloes vs. Houston Cougars Prediction

I’m leaning towards Colorado and the points here. It’ll be interesting to see how Deion Sanders and the Buffaloes navigate this quarterback situation they have going on, but I think they’ll weather the storm just fine as there are a bunch of solid options in the Black and Gold. Houston has some QB stability with Weigman, but the Buffs have been great under Deion as an underdog, and I just think this is a field goal kind of game. Give me the Buffs and the points.